Topics and Activities

Topics

• Vaccine-Oriented Phase I/II Clinical Trial Design (Part 1)
• Approaches to Tumor Antigen Discovery
• Considerations in Carrying Out Phase III Clinical Trials
• Vaccine-Oriented Phase I/II Clinical Trial Design (Part 2)
• Assessment of Immunologic Responses to Cancer Vaccines
• Vaccine Adjuvants
• Molecular Monitoring of Minimal Residual Disease
• Alternative Assays for Monitoring Immune Responses
• Strategies for Organizing a Central Lab (Core Facility)
• Immunologic Monitoring of Vaccine Trials
• Strategies for Centralized Monitoring II
• Dendritic Cells and Dendritic Cell Fusions as Cancer Vaccines
• CGAP Mining for Potential New Tumor Antigens
• CGAP Mining for Potential New Tumor Antigens II
• Proteomic Approaches to the Identification of Novel Tumor Antigens
• ELISPOT Assays
• Further Proteomic Approaches to Novel Tumor Antigens
• Novel Imaging Techniques for Monitoring Clinical Trials
• Regulatory T cells in Cancer (T cell regulation and NKT)
• Relationship between T cell infiltration into human cancers and prognosis
• How infiltrating T cells affect human cancer
• Progress in cancer vaccine clinical trials: Prostate cancer vaccines and GVAX
• HIV vaccine approaches from the Institute of Human Virology
• Monoclonal antibodies to HIV
• TGF-beta in the immune response to cancer
• Inactivated tumor cells or virions as vaccines
• Myeloid-derived suppressor cells and vaccine immunity
• Brain Cancer vaccines
• Use of modified subdominant epitopes as vaccine antigens
• Mucosal immunity and vaccines for HIV
• Glycopeptide vaccines for HIV
• Epigenetic changes in T cell activation and in trained innate immunity
• Role of the gut microbiome and aging on the immune response and cancer immunity

Activities and Projects

• Organizational Meeting and Agenda Planning
• Small Animal Models for Cancer Vaccines and Cancer (joint project with Cancer Prevention Models Working Group)
• Novel Approaches to Breast Cancer Vaccines and Immunotherapy (joint project with Breast Cancer Faculty
  and MOCRU Breast Cancer Section)
• Novel Approaches to HIV and HPV Vaccines (joint project with HIV and Cancer Virology Faculty)
• Coordinating the war on AIDS at NIH (joint project with the HIV and Cancer Virology Faculty)
• Role of IL-23, IL-12, and IL-27 in T cell infiltration into tumors and tumor immunosurveillance (joint project with Cancer and Inflammation Program)