Topics and Activities
Topics
- Vaccine-Oriented Phase I/II Clinical Trial Design (Part 1)
- Approaches to Tumor Antigen Discovery
- Considerations in Carrying Out Phase III Clinical Trials
- Vaccine-Oriented Phase I/II Clinical Trial Design (Part 2)
- Assessment of Immunologic Responses to Cancer Vaccines
- Vaccine Adjuvants
- Molecular Monitoring of Minimal Residual Disease
- Alternative Assays for Monitoring Immune Responses
- Strategies for Organizing a Central Lab (Core Facility)
- Immunologic Monitoring of Vaccine Trials
- Strategies for Centralized Monitoring II
- Dendritic Cells and Dendritic Cell Fusions as Cancer Vaccines
- CGAP Mining for Potential New Tumor Antigens
- CGAP Mining for Potential New Tumor Antigens II
- Proteomic Approaches to the Identification of Novel Tumor Antigens
- ELISPOT Assays
- Further Proteomic Approaches to Novel Tumor Antigens
- Novel Imaging Techniques for Monitoring Clinical Trials
- Regulatory T cells in Cancer (T cell regulation and NKT)
- Relationship between T cell infiltration into human cancers and prognosis
- How infiltrating T cells affect human cancer
- Progress in cancer vaccine clinical trials: Prostate cancer vaccines and GVAX
- HIV vaccine approaches from the Institute of Human Virology
- Monoclonal antibodies to HIV
- TGF-beta in the immune response to cancer
- Inactivated tumor cells or virions as vaccines
- Myeloid-derived suppressor cells and vaccine immunity
- Brain Cancer vaccines
- Use of modified subdominant epitopes as vaccine antigens
- Mucosal immunity and vaccines for HIV
- Glycopeptide vaccines for HIV
- Epigenetic changes in T cell activation and in trained innate immunity
- Role of the gut microbiome and aging on the immune response and cancer immunity
Activities and Projects
- Organizational Meeting and Agenda Planning
- Small Animal Models for Cancer Vaccines and Cancer (joint project with Cancer Prevention Models Working Group)
- Novel Approaches to Breast Cancer Vaccines and Immunotherapy (joint project with Breast Cancer Faculty
and MOCRU Breast Cancer Section) - Novel Approaches to HIV and HPV Vaccines (joint project with HIV and Cancer Virology Faculty)
- Coordinating the war on AIDS at NIH (joint project with the HIV and Cancer Virology Faculty)
- Role of IL-23, IL-12, and IL-27 in T cell infiltration into tumors and tumor immunosurveillance (joint project with Cancer and Inflammation Program)