| Description: | Bone metastases and associated pain are a major cause of morbidity and mortality in castration-resistant prostate cancer (CRPC). Most approved therapies have shown some ability to reduce soft tissue lesions but none meaningfully impacts bone metastases (as demonstrated by lack of resolution of lesions on bone scan with these agents) or the pain associated with these metastases. This study will evaluate the effect of cabozantinib versus mitoxantrone plus prednisone on pain response and bone scan response in men with CRPC. |
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| Link: | http://clinicaltrials.gov/ct2/show/NCT01522443 |
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| Site: | George Washington University |
| Principle Investigator: | Hiwot Guebre-Xabiher |