Intramural Request for Archived Human Biological Material

Requesting Material through the Tissue Resource Committee (TRC) Program

Please provide all information requested on the Tissue Resource Committee (TRC) form to Ms. Silke Williams, Bldg. 10, Room 2S249, so that we may review the request in full.

  1. TRC requests could take up to three (3) weeks to complete, depending on our clinical workload and other Archivist priorities.
  2. The requester completes the TRC Request Form and returns it to the Archivist, along with the associated IRB-approved protocol number or an exemption letter from the Office of Human Subjects Research (OHSR), if necessary.
  3. The Archivist assigns a TRC number to the request, creates a paper file folder for the request,and logs the request into the TRC Excel spreadsheet on the Laboratory of Pathology (LP’s) server, which is also available to the Clinical Manager.
  4. The Archivist will review the request with the Clinical Manager to determine completion of requisition, OHSR / IRB compliance, and to determine if the request can be completed inhouse or if the recuts must be sent out to a reference laboratory. If the processing / recuts cannot be done inhouse, the requesting PI will be notified if his/her CAN will be billed, and the cost of the work.
  5. Key requirements for intramural requests are:
  6. If the request requires pathologist review, the Archivist will direct the TRC to the Resident on Autopsy service or Surgical Pathology Attending on service. Physician review may be required for:
  7. If anonymized (unlinked) material is requested, the Archivist or another LP employee will unlink the source. For example, if anonymized recuts are sent to a reference lab for cutting, a random number will be assigned to the block before the blocks are sent out. Slides will be labeled with the random number. The label will be removed from the block before it is returned to the file.
  8. The Archivist will also notify the Pathologists Assistants and/or Resident on the autopsy service, if fresh autopsy materials are requested.

Requests for Paraffin-Embedded (Whole) Tissue Blocks

LP does not routinely release whole tissue blocks. Any request for blocks must be submitted the Branch Chief / Medical Director with a justification of the need for the block(s) rather than slides. Only the Branch Chief of LP can approve the release of tissue blocks.

Requests for Research Immunohistochemistry (IHC)

Obtaining Tissues through the NCI / Walter Reed Tissue Collaboration

The NCI Laboratory of Pathology and the Walter Reed National Military Medical Center (WRNMMC) have a collaborative project in which formalin preserved and fresh frozen excess human surgical tissues and associated clinical information can be obtained for NCI and NIH investigators. PIs interested in obtaining tissues that are not available at the NIH should complete the TRC Request Form and contact Dr. David Kleiner or Dr. Joseph Chinquee to discuss this possibility.