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Center for Cancer Research National Cancer Institute
Molecular Targets Laboratory

Project Proposal Seminar List




 Project Manager(s)

December 18, 2000

Philipp Kaldis

Cyclin Dependent Kinases as Potential Screening Targets



August 8, 2001

Chem Akin
Diana Linnekin

Mastocytosis: The Disease, Therapeutic Challenges and Potential Opportunities



December 7, 2001

Gordon Hager

The Dynamics of Nuclear Receptor Induced Chromatin Remodeling and Gene Activation

Beutler, Dull


May 1, 2002

Stuart LeGrice

A High Throughput Screen for HIV-1 RNase H Inhibitors



September 9, 2002

Sam Hwang

Chemokine Receptors in Cancer Metastasis



January 22, 2003

Ji Ming Wang

Formylpeptide Receptors as Potential Targets for Drug Development



January 28, 2003

Chou-Chi Li

Involvement of p97-VCP as a Molecular Chaperone in the Ubiquitin- Proteasome Pathway Mediated Activities



February 12, 2003

Keith Robertson

Inhibition of DNA Methyltransferases as a Novel Strategy for Cancer Treatment



February 19, 2003

Michael Dean

The Role of the ABC Transporter ABCG2/MXR in Multidrug Resistance



March 10, 2003

Marston Linehan

Potential Molecular Targets and Cancer of the Kidney



March 14, 2003

Suresh Arya

Lentiviral Gene Transfer: Search for "Drugs" to Target Transcriptional and Post-transcriptional Apparatus



March 18, 2003

Victor Lobanenkov

BORIS - A Novel Testis- Specific Paralogue of CICF-Maps to a Cancer Associated Chromosome 20q13 Gain-Amplification Region, Shows Aberrantly Activated Expression in Many Types of Malignancies, and Transforms Cells in Culture



April 23, 2003

Daniel McVicar

The Killer Ig-like Receptors (KIR) and Triggering Receptors Expressed on Myeloid Cells (TREM) as Potential Targets for the Treatment of Infectious Disease and Cancer



May 9, 2003

Laura Schmidt

Functional Studies of the Birt-Hogg-Dube Protein, Folliculin, Through Identification of Interacting Proteins



July 29, 2003

Nancy Colburn

Discovery of a Drug that Mimics the Targeting Specificity of Dominant Negative AP-1



October 27, 2003

Brad St. Croix

Unraveling Novel Signaling Pathways that Regulate Tumor Angiogenesis: A Hunt for the TEM5 Ligand



January 8, 2004

Shyam Sharan

Functional Dissection of Human Breast Cancer Susceptibility Genes



February 19, 2004

David Gius

Thioredoxin as a molecular target



April 15, 2004

Thomas Sayers

Death receptor - mediated apoptosis and cancer therapy



April 19, 2004

Peter Johnson
Esta Sterneck

Transcription factor C/EBPbeta: an effector of Ras-induced tumorigenesis and a potential target for pharmacological inhibition



July 7, 2004

Peter Aplan

SCL Gene Activation Leads to T-Cell Acute Lymphoblastic Leukemia in Mice and Men



September 21, 2004

Allan Weissman

A novel E2 binding site and a Cue domain are critical to the ERAF ubiquitin ligase (E3) function of gp78, the tumor autocrine motility factor receptor



October 6, 2004

Giovanni Mellilo

Screening a Peptide Phage Display Library to Identify HIF-1 alpha Inhibitors



March 16, 2005

Andrew Hurwitz

Identifying novel antigens on a subset of T lymphocytes, regulatory T cells or 'Tregs'



April 13, 2005

Teizo Yoshimura

Discoidin Domain Receptor 1 (DDR1): A New Class of Collagen Receptor



May 31, 2005

Joseph Riss

Cancers as Wounds that Do Not Heal: Simlarities and Differences Between Renal Regeneration and Renal Carcinoma



July 12, 2005

Donald Bottaro

Signal Transduction by Hepatocyte Factor



September 16, 2005

David Salomon

Cripto 1: An Oncofetal Gene as a Therapeutic Target in Cancer



December 7, 2005

Kyung S. Lee

The polo-box domain of Polo-like kinase 1 as a potential therapeutic target


March 22, 2006

Seong-Jin Kim

Trk Neurotrophin Receptor Kinases: Their Functional Involvement in Human Cancers


December 14, 2006

Sandra Ruscetti & Gordon Macpherson

A High Throughput Screen to Identify Anti Adhesion Compounds for Leukemia


February 23, 2007

Glenn Merlino

Targeting p53-independent Arf activity in melanoma genesis


July 9, 2007

Paul Randazzo

ASAP-type Arf GTPase-activating proteins: Enzymatic regulators of membrane remodeling associated with cancer cell invasion


September 18, 2007

Doug Figg

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway


October 4, 2007

Nancy Colburn

Pdcd4 stability


January 16, 2008

Dalit Barkan

In vitro and In Vivo Approaches to Studying Tumor Cell Dormancy


February 6, 2008

Karlyne Reilly

Preclinical Testing of Astrocytoma in a Mouse Model of Neurofibromatosis Type 1


June 18, 2008

Andre Nussenzweig

Critical functions for DNA-PKcs in DNA double strand break repair and apoptosis revealed in the absence of ATM


July 10, 2008

Patricia Steeg

Strategies to suppress metastasis:  nm23


December 1, 2008

Lou Staudt

New Molecular Targets in Lymphoma


February 26, 2009

Samir Khleif

T-regulatory cells and the PI3K pathway


March 24, 2009

Prasun Misra

Novel anti-cancer therapy: Targeting carcinoma-associated fibroblasts in the tumor microenvironment


October 7, 2009

Raza Zaidi

Role for IFN-gamma in UV-induced melanocyte activation and melanomagenesis


December 17, 2009

Frank Cuttita

The Quest for New Anti-Angiogenic Agents


April 30, 2010

Joseph Riss

Extracellular ATP Combination Therapy Based On The Concept Of Cancers As Wounds That Do Not Heal


June 14, 2010

Phil Dennis

High Throughput Screening to Identify Inducers of the Tumor Suppressor RhoB


June 29, 2010

Xin Wei Wang

EpCAM/beta-catenin is entering HTS


June 30, 2010

Peter Aplan

IL3 as a target for adjunctive therapy of hematologic malignancy


August 5, 2010

Vinay Pathak

APOBEC3G and APOBEC3F Interactions with Vif: Multiple Targets for Antiviral Drug Development


September 8, 2010

Michael Maurizi

Targeting ATP-dependent Clp proteases: you can't live with 'em, you can't live without 'em


November 15, 2010

Jonathan Ashwell

Alternative p38 activation pathway in T cells:  Role in inflammatory and autoimmune disease


February 2, 2011

Kevin Gardner

Transcriptional regulation of BRCA1 expression by a metabolic switch


April 27, 2011

Francis Flomerfelt

Tbata modulates thymic stromal cell proliferation and thymus function


June 1, 2011

Doug Figg

The role of an androgen transporter, OATP1B3, in prostate cancer


June 13, 2011

Stu Yuspa

Active transport through keratinocyte P-glycoprotein as a mechanism of percutaneous drug absorption for the treatment of skin cancer and other cutaneous and systemic diseases


September 21, 2011

Chand Khanna

Determinants of the metastatic phenotype in sarcoma


October 3, 2011

Julia Arnold

The EPI* Bioassay Identification of the *Endocrine/Paracrine/Immune Mechanisms in Natural Products and Phytomedicines


January 26, 2012

Jay Schneekloth

Searching for Inhibitors of Protein Sumoylation: Overview and Anticancer Potential


November 28, 2012

Stuart Le Grice

Identification and Development of Allosteric Inhibitors of HIV-1 Integrase (ALLINIs)


May 7, 2013David RobertsTargeting CD47 to control radioresistance in tumors and their hosts 
May 29. 2013Vladimir LarionovArtificial chromosomes carrying a functional kinetochore as a new tool to measure chromosome instability (CIN) in human cells 
January 23, 2014Lalage WakefieldA fluorescent cancer stem cell reporter with potential for high throughput drug screeningTBD
October 28, 2014Stan LipkowitzStructure and function of Cbl proteins and the potential for therapeutic targetingTBD
November 12, 2014Javed KhanDevelopment of a high-throughput screen to identify inhibitors of the fusion gene PAX3-FOXO1 in pediatric RhabdomyosarcomaTBD
December 15, 2014Shiv GrewalNuclear RNA processing and epigenetic genome controlTBD
February 19, 2015Yves PommierDiscovery of Human Tyrosyl DNA Phosphodiesterase 2 (TDP2) Inhibitors 
April 7, 2015Debbie MorrisonRaf Kinase Signaling: Targeting Regulatory Interactions for Cancer TherapyTBD
September 29, 2015Frank McCormick, Matt Holderfield & Tommy TurbyvilleTargeting Ras: Overview and AssaysTBD

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Added by Beutler, John (NIH/NCI) [E] , last edited by Beutler, John (NIH/NCI) [E] on Sep 30, 2015 10:14