Project Seminars
Date | Investigator | Title | Project Manager(s) | |
December 18, 2000 | Philipp Kaldis | Cyclin Dependent Kinases as Potential Screening Targets | O'Keefe |
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August 8, 2001 | Chem Akin | Mastocytosis: The Disease, Therapeutic Challenges and Potential Opportunities | Gustafson |
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December 7, 2001 | Gordon Hager | The Dynamics of Nuclear Receptor Induced Chromatin Remodeling and Gene Activation | Beutler, Dull |
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May 1, 2002 | Stuart LeGrice | A High Throughput Screen for HIV-1 RNase H Inhibitors | Beutler |
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September 9, 2002 | Sam Hwang | Chemokine Receptors in Cancer Metastasis | Gardella |
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January 22, 2003 | Ji Ming Wang | Formylpeptide Receptors as Potential Targets for Drug Development | McKee |
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January 28, 2003 | Chou-Chi Li | Involvement of p97-VCP as a Molecular Chaperone in the Ubiquitin- Proteasome Pathway Mediated Activities | McKee |
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February 12, 2003 | Keith Robertson | Inhibition of DNA Methyltransferases as a Novel Strategy for Cancer Treatment | Beutler |
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February 19, 2003 | Michael Dean | The Role of the ABC Transporter ABCG2/MXR in Multidrug Resistance | Gustafson, |
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March 10, 2003 | Marston Linehan | Potential Molecular Targets and Cancer of the Kidney | McKee |
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March 14, 2003 | Suresh Arya | Lentiviral Gene Transfer: Search for "Drugs" to Target Transcriptional and Post-transcriptional Apparatus |
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March 18, 2003 | Victor Lobanenkov | BORIS - A Novel Testis- Specific Paralogue of CICF-Maps to a Cancer Associated Chromosome 20q13 Gain-Amplification Region, Shows Aberrantly Activated Expression in Many Types of Malignancies, and Transforms Cells in Culture | Gustafson, |
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April 23, 2003 | Daniel McVicar | The Killer Ig-like Receptors (KIR) and Triggering Receptors Expressed on Myeloid Cells (TREM) as Potential Targets for the Treatment of Infectious Disease and Cancer | McKee |
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May 9, 2003 | Laura Schmidt | Functional Studies of the Birt-Hogg-Dube Protein, Folliculin, Through Identification of Interacting Proteins | Mori |
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July 29, 2003 | Nancy Colburn | Discovery of a Drug that Mimics the Targeting Specificity of Dominant Negative AP-1 | Henrich |
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October 27, 2003 | Brad St. Croix | Unraveling Novel Signaling Pathways that Regulate Tumor Angiogenesis: A Hunt for the TEM5 Ligand |
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January 8, 2004 | Shyam Sharan | Functional Dissection of Human Breast Cancer Susceptibility Genes |
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February 19, 2004 | David Gius | Thioredoxin as a molecular target |
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April 15, 2004 | Thomas Sayers | Death receptor - mediated apoptosis and cancer therapy | Bokesch |
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April 19, 2004 | Peter Johnson | Transcription factor C/EBPbeta: an effector of Ras-induced tumorigenesis and a potential target for pharmacological inhibition |
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July 7, 2004 | Peter Aplan | SCL Gene Activation Leads to T-Cell Acute Lymphoblastic Leukemia in Mice and Men |
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September 21, 2004 | Allan Weissman | A novel E2 binding site and a Cue domain are critical to the ERAF ubiquitin ligase (E3) function of gp78, the tumor autocrine motility factor receptor | Beutler |
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October 6, 2004 | Giovanni Mellilo | Screening a Peptide Phage Display Library to Identify HIF-1 alpha Inhibitors | Mori |
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March 16, 2005 | Andrew Hurwitz | Identifying novel antigens on a subset of T lymphocytes, regulatory T cells or 'Tregs' |
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April 13, 2005 | Teizo Yoshimura | Discoidin Domain Receptor 1 (DDR1): A New Class of Collagen Receptor |
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May 31, 2005 | Joseph Riss | Cancers as Wounds that Do Not Heal: Simlarities and Differences Between Renal Regeneration and Renal Carcinoma |
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July 12, 2005 | Donald Bottaro | Signal Transduction by Hepatocyte Factor |
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September 16, 2005 | David Salomon | Cripto 1: An Oncofetal Gene as a Therapeutic Target in Cancer | Henrich |
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December 7, 2005 | Kyung S. Lee | The polo-box domain of Polo-like kinase 1 as a potential therapeutic target | Kurian | |
March 22, 2006 | Seong-Jin Kim | Trk Neurotrophin Receptor Kinases: Their Functional Involvement in Human Cancers |
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December 14, 2006 | Sandra Ruscetti & Gordon Macpherson | A High Throughput Screen to Identify Anti Adhesion Compounds for Leukemia |
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February 23, 2007 | Glenn Merlino | Targeting p53-independent Arf activity in melanomagenesis |
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July 9, 2007 | Paul Randazzo | ASAP-type Arf GTPase-activating proteins: Enzymatic regulators of membrane remodeling associated with cancer cell invasion |
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September 18, 2007 | Doug Figg | Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway | McKee | |
October 4, 2007 | Nancy Colburn | Pdcd4 stability | Henrich | |
January 16, 2008 | Dalit Barkan | In vitro and In Vivo Approaches to Studying Tumor Cell Dormancy | ||
February 6, 2008 | Karlyne Reilly | Preclinical Testing of Astrocytoma in a Mouse Model of Neurofibromatosis Type 1 | Henrich | |
June 18, 2008 | Andre Nussenzweig | Critical functions for DNA-PKcs in DNA double strand break repair and apoptosis revealed in the absence of ATM |
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July 10, 2008 | Patricia Steeg | Strategies to suppress metastasis: nm23 |
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December 1, 2008 | Lou Staudt | New Molecular Targets in Lymphoma | O'Keefe | |
February 26, 2009 | Samir Khleif | T-regulatory cells and the PI3K pathway | McKee | |
March 24, 2009 | Prasun Misra | Novel anti-cancer therapy: Targeting carcinoma-associated fibroblasts in the tumor microenvironment |
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October 7, 2009 | Raza Zaidi | Role for IFN-gamma in UV-induced melanocyte activation and melanomagenesis |
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December 17, 2009 | Frank Cuttita | The Quest for New Anti-Angiogenic Agents |
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April 30, 2010 | Joseph Riss | Extracellular ATP Combination Therapy Based On The Concept Of Cancers As Wounds That Do Not Heal |
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June 14, 2010 | Phil Dennis | High Throughput Screening to Identify Inducers of the Tumor Suppressor RhoB | ||
June 29, 2010 | Xin Wei Wang | EpCAM/beta-catenin is entering HTS | Henrich | |
June 30, 2010 | Peter Aplan | IL3 as a target for adjunctive therapy of hematologic malignancy |
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August 5, 2010 | Vinay Pathak | APOBEC3G and APOBEC3F Interactions with Vif: Multiple Targets for Antiviral Drug Development | ||
September 8, 2010 | Michael Maurizi | Targeting ATP-dependent Clp proteases: you can't live with 'em, you can't live without 'em | O'Keefe | |
November 15, 2010 | Jonathan Ashwell | Alternative p38 activation pathway in T cells: Role in inflammatory and autoimmune disease | O'Keefe/Wilson | |
February 2, 2011 | Kevin Gardner | Transcriptional regulation of BRCA1 expression by a metabolic switch |
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April 27, 2011 | Francis Flomerfelt | Tbata modulates thymic stromal cell proliferation and thymus function | ||
June 1, 2011 | Doug Figg | The role of an androgen transporter, OATP1B3, in prostate cancer | ||
June 13, 2011 | Stu Yuspa | Active transport through keratinocyte P-glycoprotein as a mechanism of percutaneous drug absorption for the treatment of skin cancer and other cutaneous and systemic diseases | Gustafson | |
September 21, 2011 | Chand Khanna | Determinants of the metastatic phenotype in sarcoma | Henrich | |
October 3, 2011 | Julia Arnold | The EPI* Bioassay Identification of the *Endocrine/Paracrine/Immune Mechanisms in Natural Products and Phytomedicines | ||
January 26, 2012 | Jay Schneekloth | Searching for Inhibitors of Protein Sumoylation: Overview and Anticancer Potential | O'Keefe | |
November 28, 2012 | Stuart Le Grice | Identification and Development of Allosteric Inhibitors of HIV-1 Integrase (ALLINIs) | Beutler | |
| May 7, 2013 | David Roberts | Targeting CD47 to control radioresistance in tumors and their hosts | Henrich | |
| May 29. 2013 | Vladimir Larionov | Artificial chromosomes carrying a functional kinetochore as a new tool to measure chromosome instability (CIN) in human cells | ||
| January 23, 2014 | Lalage Wakefield | A fluorescent cancer stem cell reporter with potential for high throughput drug screening | Woldemichael | |
| October 28, 2014 | Stan Lipkowitz | Structure and function of Cbl proteins and the potential for therapeutic targeting | Wilson | |
| November 12, 2014 | Javed Khan | Development of a high-throughput screen to identify inhibitors of the fusion gene PAX3-FOXO1 in pediatric Rhabdomyosarcoma | Woldemichael | |
| December 15, 2014 | Shiv Grewal | Nuclear RNA processing and epigenetic genome control | ||
| February 19, 2015 | Yves Pommier | Discovery of Human Tyrosyl DNA Phosphodiesterase 2 (TDP2) Inhibitors | O'Keefe | |
| April 7, 2015 | Debbie Morrison | Raf Kinase Signaling: Targeting Regulatory Interactions for Cancer Therapy | Henrich/Gustafson | |
| September 29, 2015 | Frank McCormick, Matt Holderfield & Tommy Turbyville | Targeting Ras: Overview and Assays | Woldemichael | |
| February 3, 2016 | Isaac Brownell | Screening Natural Products to Treat Merkel Cell Carcinoma | Beutler | |
| December 12, 2017 | Kylie Walters | Proteasome deunbiquitinating enzymes as therapeutic targets | Wilson | |
| January 31, 2018 | Julianna Martinez Fiesco & Ping Zhang | DNAJB1-PRKACA chimera in fibrolamellar carcinoma | TBD |
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