Molecular Targets Program

Selected Bibliography

2024

1. Orfanoudaki M, Akee RK, Martinez-Fructuoso L, Wang D, Kelley JA, Smith EA, Henrich CJ, Schnermann MJ, O'Keefe BR, Grkovic T. Formation of trideuteromethylated artifacts of  pyrrole-containing natural products. J Nat Prod 87: 415-423, 2024. doi: 10.1021/acs.jnatprod.3c01113. PubMed link
2. Wang, D, Jiang, W, Churiwal, M, Jia, K, Seenadera, SPD, Bokesch, HR, Woldemichael, GM, Kim, Y, Hawley, R, Wei, JS, Khan, J, O'Keefe, BR, Beutler, JA, Gustafson, KR.  "Neopetrotaurines A-C, isoquinoline alkaloids with an unprecedented taurine-bridged isoquinoline quinone moiety from the sponge Neopetrosia sp." J Nat Prod, 87: 332-339, 2024. doi:10.1021/acs.jnatprod.3c01041 PubMed link.
   

2023

1. Adekenov, SM, Spiwok, V, Beutler , JA, Maslova, O, Rakhimov, K., Cytotoxicity and antitumor activity of arglabin and its derivatives. Open Access Macedonian J Med Sci 11, 412-420, 2023. doi:10.3889/oamjms.2023.11114
2. Billmann, M; Ward, HN, Aregger, M, Costanzo, M, Andrews, BJ, Boone, C, Moffat, J, Myers, CL. Reproducibility metrics for context-specific CRISPR screens. Cell Systems 2023, 14, 418-422 e2. doi:10.1016/j.cels.2023.04.003 PubMed link 

3. Borhani, SG, Levine, MZ, Krumpe, L,H, Wilson, J, Henrich, CJ, O'Keefe, BR, Lo, DC, Sittampalam, GS, Godfrey, AG, Lunsford, RD, Mangalampalli, V, Tao, D, LeClair, CA, Thole, AP, Frey, D, Swartz, J, Rao, G, An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics. N Biotechnol 76, 13-22, 2023. doi:10.1016/j.nbt.2023.04.003 PubMed link

4. Di, X, Hardardottir,I , Freysdottir, J, Wang, D, Gustafson, KR, Omarsdottir, S, Molinski, TF., Geobarrettin D, a rare herbipoline-containing 6-bromoindole alkaloid from Geodia barretti. Molecules 28, 2937, 2023. doi: 10.3390/molecules28072937 PubMed link

5. Du, L, Wilson, BAP, Li, N, Shah, R, Dalilian, M, Wang, D, Smith, EA, Wamiru, A, Goncharova, EI, Zhang, P, O'Keefe, BR. Discovery and synthesis of a naturally derived protein kinase inhibitor that selectively inhibits distinct classes of serine/threonine kinases. J Nat Prod 86: 2283-2293, 2023. doi: 10.1021/acs.jnatprod.3c00394 PubMedlink
   
6. Eruçar, FM, Senadeeera, SPD, Beutler, JA; Miski, M. Novel sesquiterpene coumarin ethers and sulphur containing compounds of Ferula turcica and their cytotoxic activity. Molecules 2023, 28, 5733. doi:10.3390/molecules28155733 PubMed link

7. Evans, JR, Akee, RK, Chanana, S, McConachie, GD, Thornburg, CC, Grkovic, T, O'Keefe, BR. National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 screening data of natural product samples with artificial neural networks. ACS Omega 8, 9250-9256, 2023. doi:10.1021/acsomega.2c07416 PubMed link

8. Muñoz-Basagoiti, J, Monteiro, FLL, Krumpe, LRH, Armario-Najera, V, Shenoy, SR, Perez-Zsolt, D, Westgarth, HJ, Villorbina, G, Bomfim, LM, Räich-Regué, D, Nogueras, L, Henrich, CJ, Gallemi, M, Moreira, FRR, Torres, P, Wilson, J, D'Arc, M, Marfil, S, Herlinger, AL, Pradenas, E, Higa, LM, Portero-Otin, M, Trinité, B, Twyman, RM, Capell, T, Tanuri, A, Blanco, J, Izquierdo-Useros, N, Rech, EL, Christou, P, O'Keefe, BR. Cyanovirin-N binds to select SARS-Cov-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-Cov-2. Proc Natl Acad Sci U S A 120, e2214561120, 2023. doi:10.1073/pnas.2214561120 PubMed link

9. Nangarlia, A, Hassen, FF, Canziani, G, Bandi, P, Talukder, C, Zhang, F, Krauth, D, Gary, EN, Weiner, DB, Bieniasz, P, Navas-Martin, S, O'Keefe, BR, Ang, CG, Chaiken, I. Irreversible inactivation of SARS-Cov-2 by lectin engagement with two glycan clusters on the spike protein. Biochemistry 62, 2115-2127, 2023. doi:10.1021/acs.biochem.3c00109 PubMed link
10. Orfanoudaki, M, Smith, EA, Hill, NT, Garman, KA, Brownell, I, Copp, BR, Grkovic, T, Henrich, CJ. An investigation of structure-activity relationships and cell death mechanisms of the marine alkaloids discorhabdins in Merkel cell carcinoma cells. Mar Drugs 21, 474, 2023. doi: 10.3390/md21090474 PubMed link
    
11. Sun, B; Wang, D; Ren, J; Wang, C; Yan, P; Gustafson, KR, Jiang, W. Paraconulones A-G: Eremophilane sesquiterpenoids from the marine-derived fungus Paraconiothyrium sporulosum DL-16. J Nat Prod 86, 1360-1369, 2023. doi: 10.1021/acs.jnatprod.3c00221, PubMed link
    
12. Takada, K; Oku, N; Peach, ML; Ransom, TT; Henrich, CJ; Gustafson, KR. Enigmazole phosphomacrolides from the marine sponge Cinachyrella enigmatica. J Org Chem 88, 10996-11002, 2023. doi: 10.1021/acs.joc.3c00963 PubMed link
13. Tian, X; Wang, D; Jiang, W; Bokesch, HR; Wilson, BAP; O'Keefe, BR; Gustafson, KR. Rare caulamidine hexacyclic alkaloids from the marine ascidian Polyandrocarpa sp. J Nat Prod 86, 1855-1861, 2023. doi:10.1021/acs.jnatprod.3c00393 PubMed link
14. Tosun, F, Beutler, JA, Miski, M. Coumarins from the dichloromethane root extract of Heptaptera triquetra (Vent.) Tutin and their cytotoxic activities. Rec Nat Prod, 17: 998-1005, 2023. 
15. Wilson, BAP; Li, N; Dalilian, M; Wang, D; Smith, EA; Wamiru, A; Goncharova, EI; Beutler, JA; Grkovic, T; O'Keefe, BR; Zhang, P. Biochemical discovery, intracellular evaluation, and crystallographic characterization of synthetic and natural product adenosine 3',5'-cyclic monophosphate dependent protein kinase A (PKA) Inhibitors. ACS Pharmacol Transl Sci 6, 633-650 2023. PubMed link

2022

1. Armario-Najera V, Blanco-Perera A, Shenoy SR, Sun Y, Marfil S, Munoz-Basagoiti J, Perez-Zsolt D, Blanco J, Izquierdo-Useros N, Capell T, O'Keefe BR, Christou P. Physicochemical characterization of the recombinant lectin scytovirin and microbicidal activity of the SD1 domain produced in rice against HIV-1. Plant Cell Rep 41: 1013-1023, 2022. doi.org/10.1007/s00299-022-02834-5. PubMed link
2. Hamilton KD, Czajkowski D, Kong NJ, Tran TD, Gustafson KR, Pauly G, Boyle GM, Simmons JL, Steadman R, Moseley R, Brooks PR, Ogbourne SM, Russell FD. Anti-fibrotic potential of tomentosenol A, a constituent of cerumen from the Australian native stingless bee, Tetragonula carbonaria. Antioxidants 11: 2022. doi:10.3390/antiox11081604. PubMed link
3. Jiang W, Tian X, Wang D, Bokesch HR, Thomas CL, Woldemichael GM, Gryder BE, Wei JS, Song YK, Chou HC, Khan J, O'Keefe BR, Gustafson KR. Dentithecamides A-H, Diacylated zoanthoxanthin derivatives with PAX3-FOXO1 inhibitory activity from the hydroid Dentitheca habereri. J Nat Prod 85: 1419-1427, 2022. doi.org/10.1021/acs.jnatprod.2c00246. PubMed link
4. Khong, QT, Li, D, Wilson, BAP, Ranguelova, K, Dalilian, M, Smith, EA, Wamiru, A, Goncharova, E,I, Grkovic, T, Voeller, D, Lipkowitz, S, Schnermann, MJ, O'Keefe, BR, Du, L. Photochemical dimerization of plakinidine B leads to potent inhibition of the E3 ubiquitin-protein ligase Cbl-B. Org Lett 24, 9468-9472, 2022. doi:10.1021/acs.orglett.2c03922 PubMed link
5. Mair B, Aregger M, Tong AHY, Chan KSK, Moffat J. A method to map gene essentiality of human pluripotent stem cells by genome-scale CRISPR screens with inducible Cas9. Meth Mol Biol 2377: 1-27, 2022. doi: 10.1007/978-1-0716-1720-5_1. PubMed link
6. Senadeera, SPD, Long, SA, Akee, R, Bermudez, G, Parsonage, G, Strope, JD, Peer, CJ, Figg, WD, Parker, KA, Beech, DJ, Beutler, JA. Biological effects of modifications of the englerin A glycolate. ACS Med Chem Lett 2022, 13, 1472-1476. doi: PubMed link
7. Senadeera SPD, Wang D, Kim CK, Smith E, Henrich CJ, Alexander PA, Stephen AG, Durrant DE, Morrison DK, Cichewicz RH, Beutler JA. Tolypocladamides A-G, bioactive peptaibols from the fungus Tolypocladium inflatum. J Nat Prod 85: 1603-1616, 2022. doi: 10.1021/acs.jnatprod.2c00240 PubMed link
8. Stockdale DP, Beutler JA, Wiemer DF. Substitution of a triazole for the central olefin in biologically active stilbenes. ACS Med Chem Lett 2022, in press. doi: 10.1016/j.bmcl.2022.128980
9. Sun PT, Cao YG, Xue GM, Li M, Zhang CL, Zhao F, Cao ZY, Wang D, Gustafson KR, Zheng XK, Feng WS, Chen H. Hypeisoxazole A, a racemic pair of tetrahydroisoxazole-fused benzylisoquinoline alkaloids from Hypecoum erectum and structural revision of hypecoleptopine. Org Lett 24: 1476-1480, 2022. doi: 10.1021/acs.orglett.2c00096. PubMed link
10. Teleshova N, Keller MJ, Fernandez Romero JA, Friedland BA, Creasy GW, Plagianos MG, Ray L, Barnable P, Kizima L, Rodriguez A, Cornejal N, Melo C, Cruz Rodriguez G, Mukhopadhyay S, Calenda G, Sinkar SU, Bonnaire T, Wesenberg A, Zhang S, Kleinbeck K, Palmer K, Alami M, O'Keefe BR, Gillevet P, Hur H, Liang Y, Santone G, Fichorova RN, Kalir T, Zydowsky TM. Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel. PLoS One 17: e0261775, 2022. doi:10.1371/journal.pone.0261775. PubMed link

2021

1. Alsaidi S, Cornejal N, Mahoney O, Melo C, Verma N, Bonnaire T, Chang T, O'Keefe BR, Sailer J, Zydowsky TM, Teleshova N, Romero JAF. Griffithsin and carrageenan combination results in antiviral synergy against SARS-CoV-1 and 2 in a pseudoviral model. Mar Drugs 19: 2021, doi: 10.3390/md19080418. PubMed link
2. Cortelo P, Demarque DP, Dusi RG, Albernaz LC, Braz-Fliho R, Goncharova EI, Bokesch HR, Gustafson KR, Beutler JA, Espindola LS. A Molecular networking strategy: High throughput screening and chemical analysis of Brazilian Cerrado plant extracts against cancer cells. Cells, 10: 691, 2021. doi:10.3390/cells10030691 PubMed link 
3. Durrant DE, Smith EA, Goncharova EI, Sharma N, Alexander P, Stephen AG, Henrich CJ, Morrison DK. Development of a high-throughput NanoBRET screening platform to identify modulators of the ras/raf interaction. Mol Cancer Ther, in press, 2021, doi: 10.1158/1535-7163.MCT-21-0175. PubMed link
4. Fermaintt CS, Peramuna T, Cai SX, Takahashi-Ruiz L, Essif JN, Grant CV, O'Keefe BR, Mooberry SL, Cichewicz RH, Risinger AL. Yuanhuacine is a potent and selective inhibitor of the basal-like 2 subtype of triple negative breast cancer with immunogenic potential. Cancers 13: 2834, 2021, doi:103390/cancers13112834. PubMed link
5. Hanna GS, Choo YM, Harbit R, Paeth H, Wilde S, Mackle J, Verga JU, Wolf BJ, Thomas OP, Croot P, Cray J, Thomas C, Li LZ, Hardiman G, Hu JF, Wang X, Patel D, Schinazi RF, O'Keefe BR, Hamann MT. Contemporary approaches to the discovery and development of broad-spectrum natural product prototypes for the control of coronaviruses. J Nat Prod in press, 2021, doi: 10.1021/acs.jnatprod.1c00367. PubMed link
6. Jiang W, Wang D, Wilson BAP, Kang U, Bokesch HR, Smith EA, Wamiru A, Goncharova EI, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Agelasine diterpenoids and Cbl-b inhibitory ageliferins from the coralline demosponge Astrosclera willeyana. Mar Drugs 19: 361, 2021, doi: 10.3390/md19070361. PubMed link
7. Jiang W, Wang D, Wilson BAP, Voeller D, Bokesch HR, Smith EA, Lipkowitz S, O'Keefe BR, Gustafson KR. Sinularamides A-G, terpenoid-derived spermidine and spermine conjugates with Casitas B-lineage lymphoma proto-oncogene B (Cbl-b) inhibitory activities from a Sinularia sp. soft coral. J Nat Prod 84: 1831-1837, 202, doi: 10.1021/acs.jnatprod.1c00367. PubMed link
8. Kang U, Wang D, Bokesch HR, Gustafson KR. Four new pregnane-10,2-carbolactones from an Epipolasis sp. marine sponge. Chem Pharm Bull 69: 48-51, 2021, doi: 10.1248/cpb.c20-00128. PubMed link 
9. Kim CK, Krumpe LRH, Smith E, Henrich CJ, Brownell I, Wendt KL, Cichewicz RH, O'Keefe BR, Gustafson KR. Roseabol A, a new peptaibol from the fungus Clonostachys rosea. Molecules 26: 3594, 2021, doi 10.3390/molecules26123594. PubMed link
10. Li K, Gustafson KR. Sesterterpenoids: Chemistry, biology, and biosynthesis. Nat Prod Rep 38: 1251-1281, 2020, doi: 10.1039/d0np00070a. PubMed link
    
11. Long SA, Ren L, Wilson J, Goetz M, Hao X, Yang X, Jia L, LeBlanc A, Khanna C, Henrich CJ, Beutler JA. Identification of potential modulators of osteosarcoma metastasis by high throughput cellular screening of natural products. Chem Biol Drug Design, 97: 77-86, 2021. doi:10.1111/cbdd.13762. PubMed link
12. Schroeder CM, Dey PN, Beutler JA, Wiemer DF. Synthesis of a coumarin-based analogue of schweinfurthin F. J Org Chem 86: 16824-16833, 2021, doi: 10.1021/acs.joc.1c02046. PubMed link
13. Smith EA, Hill NT, Gelb T, Garman KA, Goncharova EI, Bokesch HR, Kim CK, Wendt KL, Cichewicz RH, Gustafson KR, Brownell I, Henrich CJ. Identification of natural product modulators of Merkel cell carcinoma cell growth and survival. Sci Rep 11: 13597, 2021, doi: 10.1038/s41598-021-93097-9. PubMed link
14. Tewary P, Brooks AD, Xu YM, Wijeratne EMK, Babyak AL, Back TC, Chari R, Evans CN, Henrich CJ, Meyer TJ, Edmondson EF, Prudente de Aquino MT, Kanagasabai T, Shanker A, Gunatilaka AAL, Sayers TJ. Small-molecule natural product physachenolide C potentiates immunotherapy efficacy by targeting Bet proteins. Cancer Res 81: 3374-3386, 2021 doi: 10.1158/0008-5472.CAN-20-2634. PubMed link
15. Tosun F, Aytar EC, Beutler JA, Miski M. Cytotoxic coumarins from the roots of Heptaptera cilicica. Rec Nat Prod, 15: 529-536, 2021, doi:10.25135/rnp.242.21.02.1990.
16. Wang D, Jiang W, Kim CK, Bokesch HR, Woldemichael GM, Gryder BE, Shern JF, Khan J, O'Keefe BR, Beutler JA, Gustafson KR. Neopetrothiazide, an Intriguing pentacyclic thiazide alkaloid from the sponge Neopetrosia sp. Org Lett, 23: 3278-3281, 2021, doi: 10.1021/acs.orglett.1c00743. PubMed link
17. Wilson BAP, Voeller D, Smith EA, Wamiru A, Goncharova EI, Liu G, Lipkowitz S, O'Keefe BR. In vitro ubiquitination platform identifies methyl ellipticiniums as ubiquitin ligase inhibitors. SLAS Discov 26: 870-884, 2021, doi:10.1177/24725552211000675. PubMed link
18. Woldemichael GM, O'Keefe BR. Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs. Structure 29: 401-403, 2021, doi:10.1016/j.str.2021.03.010. PubMed link

2020

1. Chang LS, Oblinger JL, Burns SS, Huang J, Anderson LW, Hollingshead MG, Shen R, Pan L, Agarwal G, Ren Y, Roberts RD, O'Keefe BR, Kinghorn AD, Collins JM. Targeting protein translation by rocaglamide and didesmethylrocaglamide to treat MPNST and other sarcomas. Mol Cancer Ther 19: 731-741, 2020, doi: 10.1158/1535-7163.MCT-19-0809. PubMed link
2. Grant CV, Cai S, Risinger AL, Liang H, O'Keefe BR, Doench JG, Cichewicz RH, Mooberry SL. CRISPR-Cas9 genome-wide knockout screen identifies mechanism of selective activity of dehydrofalcarinol in mesenchymal stem-like triple-negative breast cancer cells. J Nat Prod 83: 3080-3092, 2020, doi: 10.1021/acs.jnatprod.0c00642. PubMed link

3. Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR. National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid isolation and identification of biologically active natural products from the NCI prefractionated library. ACS Chemical Biology 15: 1104-1114, 2020, doi: 10.1021/acschembio.0c00139. PubMed link

4. Kang U, Cartner LK, Wang D, Kim CK, Thomas CL, Woldemichael GM, Gryder BE, Shern JF, Khan J, Castello-Branco C, Sherer EC, Wang X, Regalado EL, Gustafson KR. Denigrins and dactylpyrroles, arylpyrrole alkaloids from a Dactylia sp. marine sponge. J Nat Prod, 2020, doi: 10.1021/acs.jnatprod.0c01103. PubMed link
5. Kil YS, Risinger AL, Petersen CL, Liang H, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Using the cancer dependency map to identify the mechanism of action of a cytotoxic alkenyl derivative from the fruit of Choerospondias axillaris. J Nat Prod 83: 584-592, 2020, doi: 10.1021/acs.jnatprod.9b00896. PubMed link

6. Kim CK, Wang D, Bokesch HR, Fuller RW, Smith E, Henrich CJ, Durrant DE, Morrison DK, Bewley CA, Gustafson KR. Swinhopeptolides A and B: Cyclic depsipeptides from the sponge Theonella swinhoei that inhibit ras/raf interaction. J Nat Prod 83: 1288-1294, 2020, doi: 10.1021/acs.jnatprod.0c00136. PubMed link

7. Kim CK, Wang D, Wilson BAP, Sauri J, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Suberitamides A-C, aryl Alkaloids from a Pseudosuberites sp. marine sponge that inhibit Cbl-b ubiquitin ligase activity. Mar Drugs 18, 2020, doi: 10.3390/md18110536. PubMed link
8. Krumpe LRH, Wilson BAP, Marchand C, Sunassee SN, Bermingham A, Wang W, Price E, Guszczynski T, Kelley JA, Gustafson KR, Pommier Y, Rosengren KJ, Schroeder CI, O'Keefe BR. Recifin A, initial example of the Tyr-lock peptide structural family, is a selective allosteric inhibitor of tyrosyl-DNA phosphodiesterase I. J Am Chem Soc 142: 21178-21188, 2020. doi: 10.1021/jacs.0c10418. PubMed link 
9. Li K, Gustafson KR. Sesterterpenoids: Chemistry, biology, and biosynthesis. Nat Prod Rep, 2020, doi: 10.1039/d0np00070a. PubMed link

10. Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR, Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, Palmer KE, O'Keefe BR, Spiropoulou CF. Griffithsin inhibits Nipah virus entry and fusion and can protect Syrian golden hamsters from lethal Nipah virus challenge. J Infect Dis, 2020, doi: 10.1093/infdis/jiz630. PubMed link. 

11. Ma H, Liang H, Cai S, O'Keefe BR, Mooberry SL, Cichewicz RH. An integrated strategy for the detection, dereplication, and identification of DNA-binding biomolecules from complex natural product mixtures. J Nat Prod, 2020, doi: 10.1021/acs.jnatprod.0c00946. PubMed link
12. Pederson PJ, Cai S, Carver C, Powell DR, Risinger AL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Triple-negative breast cancer cells exhibit differential sensitivity to cardenolides from Calotropis gigantea. J Nat Prod 83: 2269-2280, 2020, doi: 10.1021/acs.jnatprod.0c00423. PubMed link
13. Shrivastava-Ranjan P, Lo MK, Chatterjee P, Flint M, Nichol ST, Montgomery JM, O'Keefe BR, Spiropoulou CF. Hantavirus infection is inhibited by griffithsin in cell culture. Front Cell Infect Microbiol 10: 561502, 2020, doi: 10.3389/fcimb.2020.561502. PubMed link

14. Strope JD, Peer CJ, Sissung TM, Hall OM, Huang PA, Harris EM, Gustafson KR, Henrich CJ, Sigano DM, Pauly GT, Schneider JP, Bates SE, Figg WD. Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain. Cancer Biol Ther 21: 223-230, 2019, doi: 10.1080/15384047.2019.1683324. PubMed link

15. Tocco G, Esposito F, Caboni P, Laus A, Beutler JA, Wilson JA, Tramontano E, Corona A, Le Grice SFJ. Scaffold hopping and optimization of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: Synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, in press. doi: 10.1080/14756366.2020.1835884. PubMed link

16. Tosun F, Mihoglugil F, Beutler JA, Ozkan EE, Miski M. Neopapillarine, an unusual coumarino-alkaloid from the root extract of Neocryptodiscus papillaris with selective cytotoxicity on renal cancer cells. Molecules 25: E3040, 2020, doi: 10.3390/molecules25133040. PubMed link

17. Tran TD, Wilson BAP, Henrich CJ, Wendt KL, King J, Cichewicz RH, Stchigel AM, Miller AN, O'Keefe BR, Gustafson KR. Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry 173: 112278, 2020, doi: 10.1016/j.phytochem.2020.112278. PubMed link

18. van der Westhuyzen AE, Ingels A, Rosiere R, Amighi K, Oberer L, Gustafson KR, Wang D, Evidente A, Maddau L, Masi M, de Villiers A, Green IR, Berger W, Kornienko A, Mathieu V, van Otterlo WAL. Deciphering the chemical instability of sphaeropsidin A under physiological conditions - degradation studies and structural elucidation of the major metabolite. Organic & biomolecular chemistry 18: 8147-8160, 2020, doi: 10.1039/d0ob01586e. PubMed link

19. Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, O'Keefe BR. Creating and screening natural product libraries. Nat Prod Rep, 2020, doi: 10.1039/c9np00068b. PubMed link

20. Wu Z, Suppo J-S, Tumova S, Strope JD, Bravo F, Moy M, Weinstein ES, Peer CJ, Figg WD, Chain WJ, Echavarren AM, Beech DJ, Beutler JA. Bridgehead modifications of englerin A reduce TRPC4 activity and intravenous toxicity but not cell growth inhibition. ACS Med Chem Lett 11: 1711-1716, 2020, doi: 10.1021/acsmedchemlett.0c00186. PubMed link

2019

1. Beutler JA. Natural products as a foundation for drug discovery. Curr Protocols Pharmacol 82: e67, 2019, doi: 10.1002/cpph.67. PubMed link

2. Grant CV, Carver CM, Hastings SD, Ramachandran K, Muniswamy M, Risinger AL, Beutler JA and Mooberry SL. Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype. Breast Cancer Res Treat 177: 345-355, 2019, doi: 10.1007/s10549-019-05324-7. Pubmed link

3. Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J and Khan J. 2019. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nature Comm 10:3004.  doi: 10.1038/s41467-019-11046-7. PubMed link

4. Kang U, Caldwell DR, Cartner LK, Wang D, Kim CK, Tian X, Bokesch HR, Henrich CJ, Woldemichael GM, Schnermann MJ, Gustafson KR. Elucidation of spirodactylone, a polycyclic alkaloid from the sponge Dactylia sp., and nonenzymatic generation from the co-metabolite denigrin B. Org Lett 21: 4750-4753, 2019. doi: 10.1021/acs.orglett.9b01636. PubMed link

5. Kim HJ, Yim SH, Han F, Kang BY, Choi HJ, Jung DW, Williams DR, Gustafson KR, Kennelly EJ, Lee IS. Biotransformed metabolites of the hop prenylflavanone isoxanthohumol. Molecules 24: 394, 2019. doi: 10.3390/molecules24030394. Pubmed link

6. Matarlo JS, Krumpe LRH, Heinz WF, Oh D, Shenoy SR, Thomas CL, Goncharova EI, Lockett SJ, O'Keefe BR. The natural product butylcycloheptyl prodiginine binds pre-Mir-21, inhibits dicer-mediated processing of pre-Mir-21, and blocks cellular proliferation. Cell Chem Biol 26: 1133-1142.e4, 2019. doi: 10.1016/j.chembiol.2019.04.011. Pubmed link

7. Tosun F, Beutler JA, Ransom TT, Miski M. Anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin, from the root extract of Heptaptera anatolica. Molecules 24: 01153, 2019, doi: 10.3390/molecules24061153.  Pubmed link

8. Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR. Secondary metabolites from the fungus Dictyosporium sp. and their MALT1 inhibitory activities. J Nat Prod 82:154-162, 2019. doi: 10.1021/acs.jnatprod.8b00871.  Pubmed link

9. Tran TD, Cartner LK, Bokesch HR, Henrich CJ, Wang XW, Mahidol C, Ruchirawat S, Kittakoop P, O'Keefe BR, Gustafson KR. NMR characterization of rearranged staurosporine aglycone analogues from the marine sponge Damiria sp. Magn Reson Chem, 2019, doi: 10.1002/mrc.4932. PubMed link

10. Valdeira ASC, Darvishi E, Woldemichael GM, Beutler JA, Gustafson KR, Salvador JAR. Madecassic acid derivatives as potential anticancer agents: Synthesis and cytotoxic evaluation. J Nat Prod, 82: 2094-2105, 2019, doi: 10.1021/acs.jnatprod.8b00864. PubMed link

11. Yan P, Li G, Wang C, Wu J, Sun Z, Martin GE, Wang X, Reibarkh M, Sauri J, Gustafson KR. Characterization by empirical and computational methods of dictyospiromide, an intriguing antioxidant alkaloid from the marine alga Dictyota coriacea. Org Lett 21: 7577-7581, 2019, doi: 10.1021/acs.orglett.9b02856. PubMed link

2018

1. Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson JD, Peet MM, Lloyd Z, Benson M, Heneine W, O'Keefe BR, Robbiani M, Martinelli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernandez-Romero JA, Zydowsky TM. Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo. Nature Communications 9: 3881, 2018. PubMed link

2. Espindola LS, Dusi RG, Demarque DP, Braz-Filho R, Yan P, Bokesch HR, Gustafson KR, Beutler JA. Cytotoxic triterpenes from Salacia crassifolia and metabolite profiling of Celastraceae species. Molecules 2018; 23: 1494. PubMed link

3. Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD. Preclinical evaluation of discorhabdins in antiangiogenic and antitumor models. Mar Drugs 16: E241, 2018. Pubmed link.

4. Liu Y, Cohen RD, Gustafson KR, Martin GE, Williamson RT. Enhanced measurement of residual chemical shift anisotropy for small molecule structure elucidation. Chem Commun 54: 4254-4257, 2018. PubMed link

5. Milanowski DJ, Oku N, Cartner LK, Bokesch HR, Williamson RT, Sauri J, Liu Y, Blinov KA, Ding Y, Li XC, Ferreira D, Walker LA, Khan S, Davies-Coleman MT, Kelley JA, McMahon JB, Martin GE, Gustafson KR. Unequivocal determination of caulamidines A and B: Application and validation of new tools in the structure elucidation tool box. Chem Sci 9: 307-314, 2018. PubMed link

6. Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Jr., Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Sci Rep 2018; 8: 17519. PubMed link

7. Rubaiy HN, Wolf D, Beutler JA, Beech DJ. Tonantzitlolone is a nanomolar potency activator of TRPC1/4/5 channels. Br J Pharmacol  175: 3361-3368, 2018. PubMed link

8. Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR. Harnessing natural product diversity for fluorophore discovery: Naturally occurring fluorescent hydroxyanthraquinones from the marine crinoid Pterometra venusta. J Nat Prod 81: 2750-2755, 2018. PubMed link

9. Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR. NCI Program for Natural Product Discovery: A publicly-accessible library of natural product fractions for high-throughput screening. ACS Chem Biol 2018, in press. PubMed link

10. Tian XR, Tang HF, Tian XL, Hu JJ, Huang LL, Gustafson KR. Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery. Future Med Chem 2018, in press. PubMed link

11. Valdeira ASC, Ritt DA, Morrison DK, McMahon JB, Gustafson KR, Salvador JAR. Synthesis and biological evaluation of new madecassic acid derivatives targeting ERK cascade signaling. Front Chem 2018; 6: 434. PubMed link

12. White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan IA, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble EL. India-United States dialogue on traditional medicine: Toward collaborative research and generation of an evidence base. J Glob Oncol 2018, DOI: 10.1200/JGO.17.00099: 1-10. PubMed link

13. Yan P, Ritt DA, Zlotkowski K, Bokesch HR, Reinhold WC, Schneekloth JS, Jr., Morrison DK, Gustafson KR. Macrophilones from the marine hydroid Macrorhynchia philippina can inhibit ERK cascade signaling. J Nat Prod 81: 1666-1672, 2018. Pubmed link

14. Zhao H, Masaoka T, Vardano B, Lynn AT, Aron K, Xia A, Beutler JA, Murelli RP, Tang L, Le Grice SFJ. Sensitivity of the C-terminal nuclease domain of Kaposi's sarcoma-associated herpesvirus ORF29 to different classes of active site ligands. Antimicrob Agents Chemother in press, 2017. PubMed link

2017

1. Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR. Identification of natural products that inhibit the catalytic function of human tyrosyl-DNA phosphodiesterase (TDP1). SLAS Discovery 22: 1093-1105, 2017. PubMed link

2. Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz MA, Beutler JA. Growth inhibition of colon cancer and melanoma cells by versiol derivatives from a Paraconiothyrium sp. J Nat Prod 80: 2037-2044, 2017. PubMed link

3. da Cunha MG, Ramos-Junior ES, Franchin M, Taira TM, Beutler JA, Franco GCN, Ikegaki M, de Alencar SM, Fukuda SY, Rosalen PL. Effects of cinnamoyloxy-mammeisin from geopropolis on osteoclast differentiation and Porphyromonas gingivalis-induced periodontitis. J Nat Prod 80: 1893-1899, 2017. PubMed link

4. Elliott DC, Beutler JA, Parker KA. The importance of a 4-alkyl substituent for activity in the englerin series. ACS Med Chem Lett 8: 746–750, 2017. PubMed link

5. Gustafson, KR, Chan, STS, Liu, Y, Assigning molecular configuration by nuclear magnetic resonance. In Modern NMR Approaches for the Structure Elucidation of Natural Products, Williams, A. J.; Martin, G. E.; Rovnyak, D., Eds. Royal Society of Chemistry: Cambridge, England; Vol. 2, pp 39-70, 2017.

6. Hirsch DR, Schiavone DV, Berkowitz AJ, Morrison LA, Masaoka T, Wilson JA, Lomonosova E, Zhao H, Patel BS, Datla SH, Hoft SG, Majidi SJ, Pal RK, Gallicchio E, Tang L, Tavis JE, Le Grice, SFJ, Beutler JA, Murelli, RP. Synthesis and biological assessment of 3,7-dihydroxytropolones. Org & Biomol Chem,16: 62-69, 2017. PubMed link

7. Irie, R, Takada, K, Ise, Y, Ohtsuka, S, Okada, S, Gustafson, KR, Matsunaga S Structure revision of poecillastrin C and the absolute configuration of the beta-hydroxyaspartic acid residue. Org Lett 19, 5395-5397, 2017. PubMed link

8. Jia L, Lin H, Oppenheim J, Howard OMZ., Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young M, Li W, Newman D, O'Keefe BR, Beutler J, Liu J, Hao X, Yang X, Ji, T, White JD. (2017) U.S. National Cancer Institute - China collaborative studies on Chinese medicine and cancer. J. Natl. Cancer Inst. Monographs 2017, lgx007. PubMed link

9. Mitchell CA, Ramessar K, O'Keefe BR. Antiviral lectins: Selective inhibitors of viral entry. Antiviral Res 142: 37-54, 2017. PubMed link

10. Stockdale DP, Beutler JA, Wiemer DF. Synthesis of amide isosteres of schweinfurthin-based stilbenes. Bioorg Med Chem, 25: 5483-5489, 2017. PubMed link

11. Wu Z, Zhao S, Fash DM, Li Z, Chain WJ, Beutler J. Englerins: A comprehensive review. J Nat Prod 80: 771-781, 2017. PubMed link

12. Xu YM, Brooks AD, Wijeratne EM, Henrich CJ, Tewary P, Sayers TJ, Gunatilaka AA. 17beta-Hydroxywithanolides as sensitizers of renal carcinoma cells to tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL) mediated apoptosis: Structure-activity relationships. J Med Chem 60: 3039-3051, 2017. PubMed link

13. Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS, Jr. Macrophilone A: Structure elucidation, total synthesis, and functional evaluation of a biologically active iminoquinone from the marine hydroid Macrorhynchia philippina. Org Lett 19: 1726-1729, 2017. PubMed link

2016

1. Caropreso V, Darvishi E, Turbyville TJ, Ratnayake R, Grohar PJ, McMahon JB, Woldemichael G. Englerin A inhibits EWS-FLI1 DNA binding in Ewings sarcoma cells, J Biol Chem, 291: 10058-10066, 2016. PubMed link

2. Chan, ST, Nani RR, Schauer EA, Martin GE, Williamson RT, Sauri J, Buevich AV, Schafer WA, Joyce LA, Goey AK, Figg WD, Ransom TT, Henrich CJ, McKee TC, Moser A, MacDonald SA, Khan S, McMahon JB, Schnermann MJ, Gustafson KR. Characterization and synthesis of eudistidine C, a bioactive marine alkaloid with an intriguing molecular scaffold. J Org Chem 81: 10631-10640, 2016. PubMed link

3. Chau CH, O'Keefe BR, Figg WD. The canSAR data hub for drug discovery, The Lancet Oncology, 17, 286, 2016. PubMed link

4. Cho N, Moon E, Kim H, Hong J, Beutler JA, Sung SH. Inhibition of nitric oxide production in BV2 microglia cells by constituents of Tetrapanax papyriferus, Molecules, 21: 459, 2016. PubMed link

5. Cho N, Kim HW, Ransom TT, Smith E, Beutler JA, Sung SH. Preparative isolation and purification of antiproliferative diarylheptanoids from Betula platyphylla by high speed counter-current chromatography, Molecules, 21: 700, 2016.  PubMed link

6. da Cunha MG, Franco GCN, Franchin M, Beutler JA, de Alencar SM, Ikegaki M, Rosalen PL. Prediction of pharmacokinetic and toxicological parameters of a 4-phenyl coumarin isolated from geopropolis: In silico and in vitro approaches. Tox. Lett., 263: 6-10, 2016. PubMed link

7. da Cunha MG, Franchin M, de Paula-Eduardo LF, Freires IA, Beutler JA, de Alencar SM, Ikegaki M, Tabchoury CPM, Cunha TM, Rosalen PL. Anti-inflammatory and anti-biofilm properties of ent-nemorosone from Brazilian geopropolis. J.Functional Foods 26: 27-35, 2016.

8. Darvishi E, Woldemichael GM, Cycloheximide inhibits actin cytoskeletal dynamics by suppressing signalling via RhoA, J Cell Biochem,, 117(12): 2886-2898, 2016. PubMed link

9. D'erasmo M, Masaoka T, Wilson JA, Hunte, Jr. EM, Beutler JA, Le Grice SFJ, Murelli RP. Traceless solid-phase alpha-hydroxytropolone synthesis. MedChemComm 7: 1789-1792, 2016.

10. Fako V, Yu Z, Henrich CJ, Ransom TT, Budhu AS, Wang XW. Inhibition of wnt/beta-catenin signaling in hepatocellular carcinoma by an antipsychotic drug pimozide. Int J Biol Sci 12: 768-775, 2016. PubMed link

11. Fash DM, Peer CJ, Li Z, Talisman IJ, Hayavi S, Ramos JW, Figg WD, Beutler JA, Chain WJ. Synthesis of a stable and orally bioavailable englerin analogue, Bioorg.Med.Chem.Lett.,26: 2641-2644, 2016. PubMed link

12. Franchin M, Rosalen PL, da Cunha MG, Silva R, Colon D, Bassi G, Alencar SM, Ikegaki M, Alves-Filho J, Cunha JF, Beutler JA, Cunha T. The anti-inflammatory activity of cinnamoyloxy-mammesin, a 4-phenylcoumarin derivative isolated from geopropolis obtained from Melipona scutellaris, depends on inhibition of MAP kinases. J Nat Prod, 79: 1828-1833, 2016. PubMed link

13. Goey AK, Chau CH, Sissung TM, Cook KM, Venzon DJ, Castro A, Ransom TR, Henrich CJ, McKee TC, McMahon JB, Grkovic T, Cadelis MM, Copp BR, Gustafson KR, Figg WD. Screening and biological effects of marine pyrroloiminoquinone alkaloids: Potential inhibitors of the HIF-1alpha/p300 interaction, J Nat Prod, 79(5): 1267-1275, 2016. PubMed link

14.  Henrich CJ. A microplate-based nonradioactive protein synthesis assay: Application to trail sensitization by protein synthesis inhibitors. PLoS One 11: e0165192, 2016. PubMed link

15.  López-Suárez L, Bravo F, Riesgo L, Ransom TT, Beutler JA, and Echavarren AM. Synthesis and biological evaluation of new (-)-englerin analogues. Chem Med Chem, 11: 1003-1007, 2016. PubMed link

16. Masaoka T, Zhao H, Hirsch DR, D'Erasmo MP, Meck C, Vardano B, Meyers MJ, Baines J, Beutler JA, Murelli RP, Tang L, Le Grice SFJ. Characterization of the C-terminal nuclease domain of herpes simplex virus pUL15 as a target of nucleotidyltransferase inhibitors. Biochemistry, 55: 809-819, 2016. PubMed link

17. Murelli RP, d'Erasmo MP, Hirsch DR, Meck C, Masaoka T, Wilson JA, Zhang B, Pal RK, Galicchio E, Beutler JA, Le Grice SFJ. Synthetic alpha-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity. MedChemComm 7: 1783-1788, 2016.

18. Osgood CL, Maloney N, Kidd CG, Kitchen-Goosen SM, Segars LE, Gebregiorgis M, Woldemichael GM, He M, Sankar S, Lessnick SL, Kang MH, Smith MA, Turner L, Madaj ZB, Winn ME, Nunez LE, Gonzalez-Sabin J, Helman LJ, Moris F, Grohar PJ. Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor. Clin.Cancer Res., 22 (16): 4105-4118, 2016. PubMed link

19. Schmid T, Blees JS, Bajer MM, Wild J, Pescatori L, Crucitti LC, Scipione L, Costi R, Henrich CJ, Brüne B, Colburn NH, Di Santo R. Diaryl sulfides as novel stabilizers of tumor suppressor Pdcd4, PLoS One, 11 (2016) e0151643. PubMed link

20. Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stoger E, Christou P, Capell T. Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV. Plant Biotechnol J, 14: 1427-1437, 2016. PubMed link

21. Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T. Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1 infection in vitro, Plant Cell Rep, 35: 1309-1319, 2016. PubMed link

22. Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, and O'Keefe BR. Discovery and characterization of a biologically active non-ATP-competitive p38 MAP kinase Inhibitor. J.Biomol.Screen. 21: 277-289, 2015. PubMed link

23. Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G. A designed "nested" dimer of cyanovirin-N increases antiviral activity, Viruses, 8 (2016). PubMed link

24. Yeo D, Huynh N, Beutler JA, Baldwin GS, He H, Nikfarjam M. Glaucarubinone combined with gemcitabine improves pancreatic cancer survival in a immunocompetent orthotopic murine model. J.Invest.Surg. 30: 1-7, 2016. PubMed link

25. Yuan W, Cheng S, Fu W, Zhao M, Li X, Cai Y, Dong J, Huang K, Gustafson KR, Yan P. Structurally diverse metabolites from the soft coral Sinularia verruca collected in the South China Sea. J.Nat.Prod.,79: 1124-1131, 2016. PubMed link

26. Zhao M, Cheng S, Yuan W, Xi Y, Li X, Dong J, Huang K, Gustafson KR, P. Yan P. Cembranoids from a Chinese collection of the soft coral Lobophytum crassum, Mar Drugs, 14 (2016). PubMed link

    
    

2015

1. Beutler JA, Development of englerins for cancer therapy, Czech Chem.Soc.Symp.Ser., 13: 174-176, 2015.

2. Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, and Gustafson KR. Structural elucidation and synthesis of eudistidine A: An unusual polycyclic marine alkaloid that blocks interaction of the protein binding domains of p300 and HIF-1alpha. J.Am.Chem.Soc. 137 (16):5569-5575, 2015. PubMed link

3. Chatterjee A, Ratner DM, Ryan CM, Johnson PJ, O'Keefe BR, Secor WE, Anderson DJ, Robbins PW, and Samuelson J. Anti-retroviral lectins have modest effects on adherence of Trichomonas vaginalis to epithelial cells in vitro and on recovery of Tritrichomonas foetus in a mouse vaginal model. PLoS One 10 (8):e0135340, 2015. PubMed link

4. da Cunha MG, de Alencar SM, Ikegaki M, Rosalen PL, Ransom TT, and Beutler JA. Major constituents of Melipona scutellaris geopropolis and their antiproliferative activity. Planta Med.  82: 190-204, 2015.PubMed link

5. Forcina GC, Castro A, Bokesch HR, Spakowicz DJ, Legaspi ME, Kucera K, Villota S, Narvaez-Trujillo A, McMahon JB, Gustafson KR, Strobel SA. Stelliosphaerols A and B, sesquiterpene-polyol conjugates from an Ecuadorian fungal endophyte. J.Nat.Prod., 78: 3005-3010, 2015. PubMed link

6. Henrich CJ, Brooks AD, Erickson KL, Thomas CL, Bokesch HR, Tewary P, Thompson CR, Pompei RJ, Gustafson KR, McMahon JB, and Sayers TJ. Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death.Dis. 6:e1666, 2015. PubMed link

7. Henrich CJ, Cartner LK, Wilson JA, Fuller RW, Rizzo AE, Reilly KM, McMahon JB, and Gustafson KR. Deguelins, natural product modulators of NF1-defective astrocytoma cell growth Identified by high-throughput screening of partially purified natural product extracts. J.Nat.Prod., 78: 2776-2781, 2015. PubMed link

8. Huynj N, Beutler JA, Shulkes A, Baldwin GS, and He H. Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1a and ß-catenin via a p-21 activated kinase 1-dependent pathway. Biochim.Biophys.Acta 1853:157-165, 2015. PubMed link

9. Jakób, M, Lubkowski, J, O'Keefe, BR, and Wlodawer, A. Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL). Acta Crystallograf., 71: 1429-1436, 2015. PubMed link

10. Jayatunga MKP, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, and Hamilton AD. Inhibition of the HIF1alpha-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). Eur.J.Med.Chem. 94:509-516, 2015. PubMed link

11. Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, and Fernandez-Romero JA. Griffithsin and carrageenan combination to target HSV-2 and HPV. Antimicrob.Agents Chemother., 59: 7290-7298, 2015.  PubMed link

12. Ma J, Pawar RS, Grundel E, Mazzola EP, Ridge CD, Masaoka T, Le Grice SFJ, Wilson JA, Beutler JA, and Krynitsky AJ. Sesquiterpenoid tropolone glycosides from Liriosma ovata. J.Nat.Prod. 78 (2):315-319, 2015. PubMed link

13. Moulaei T, Alexandre KB, Shenoy SR, Meyerson J, Krumpe LR, Constantine B, Wilson J, Buckheit R, McMahon JB, Subramaniam S, Wlodawer A, and O' Keefe BR. Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Retrovirology 12 (1):6, 2015. PubMed link

14. O'Keefe, BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, Buckheit KW, da Cunha NB, Araujo AC, Lacorte CC, Madeira L, McMahon JB, and Rech EL. Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV. Plant Biotechnol.J. (7):884-892, 2015.  PubMed link

15. Patridge EV, Darnell A, Kucera K, Phillips GM, Bokesch HR, Gustafson KR, Spakowicz DJ, Zhou L, Hungerford WM, Plummer M, Hoyer D, Narvaez-Trujillo A, Phillips AJ, Strobel SA, Pyrrolocin A, a 3-decalinoyltetramic acid with selective biological activity, isolated from Amazonian cultures of the novel endophyte Diaporthales sp. E6927E. Nat.Prod.Comm. 10: 1649-1654, 2015. PubMed link

16. Qin T, Beutler JA, and Porco, Jr JA. Synthesis of dimeric tetrahydroxanthones with varied linkages: Investigation of shapeshifting properties. J.Am.Chem.Soc. 137(48): 15225-15233, 2015. PubMed link

17. Shin HJ, Rashid MA, Cartner LK, Bokesch HR, Wilson JA, McMahon JB, and Gustafson KR. Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp. Tetrahedron Lett. 56 (28):4215-4219, 2015. PubMed link

18. Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutler JA, Linehan WM, and Neckers L. Tonantzitlolone cytotoxicity toward renal cancer cells is PKCtheta- and HSF1-dependent.  Oncotarget, 6 (30): 29963-29974, 2015. PubMed link

19. Zhao H, Lin Z, Lynn AY, Vardano B, Beutler JA, Murelli RP, Le Grice SFJ, and Tang L. Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism. Nucl.Acids Res.43: 11003-11016, 2015. PubMed link

    
    

2014

1. Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, and Brune B. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem.Pharmacol. 88 (3): 313-321, 2014. PubMed link

2. Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A, Brock G, Montefiori DC, Vojdani F, McCormick AA, O'Keefe BR, and Palmer KE. Activity and effect of subcutaneous treatment with the broad spectrum antiviral lectin griffithsin in two laboratory rodent models. Antimicrob.Agents Chemother. 58(1):120-127, 2014. PubMed link

3. Beutler JA, Cragg GM, Iwu M, Newman DJ, and Okunji C. Anticancer Potential of African Plants. The Experience of the United States National Cancer Institute and National Institutes of Health. Chapter 10 In: Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics, edited by A. Gurib-Fakim,Wiley-Blackwell, p.133-149, 2014.

4. Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, and Beutler JA. Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells. Phytochem.Lett. 7 (1):42-45, 2014. PubMed link

5. Dull AB, George AA, Goncharova EI, Evans JR, Wamiru A, Cartner LK, Hager GL, and McMahon JB. Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor a chimera and exhibit agonist or antagonist activity in vitro. J.Biomol.Screen. 19 (2):242-252, 2014. PubMed link

6. Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger Jr. GG, McMahon JB,  Huggins J, and O'Keefe BR. The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus. Antiviral Res. 112: 1-7, 2014. PubMed link

7. Grkovic T, Blees JS, Bayer MM, Colburn MM, Thomas CL, Henrich CJ, Peach ML, McMahon JB, Schmid T, and Gustafson KR. Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4. Mar.Drugs 12 (8):4593-4601, 2014. PubMed link

8. Hartung AM, Beutler JA, Navarro HA, Wiemer DF, and Neighbors JD. Stilbenes as kappa-selective non-nitrogenous opioid receptor antagonists. J.Nat.Prod. 77 (2): 311-319, 2014. PubMed link

9. Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur YH,  Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, and Reed JC. Ultra-high-throughput screening of natural product extracts to identify proapoptotic inhibitors of bcl-2 family proteins. J.Biomol.Screen. 19 (8):1201-1211, 2014. PubMed link

10. Jensen SM, Ruscetti FW, Rein A, Bertolette DC, Saucedo CJ, O'Keefe BR, and Jones KS. Differential inhibitory effects of cyanovirin-N, griffithsin and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses. J.Virol. 88 (4):2327-2332, 2014. PubMed link

11. Kodet JG, Beutler JA, and Wiemer DF. Synthesis and structure activity relationships of schweinfurthin indoles. Bioorg.Med.Chem. 22 (8): 2542-2552, 2014. PubMed link

12. Lockett SJ, Cui C, Gudla P, Nandy K, Mimaki Y, Fuchs PL, Jaja J, Reilly KM, Beutler JA, and Turbyville TJ. Quantitative analysis of F-actin redistribution in astrocytoma cells treated with candidate pharmaceuticals. Cytometry A 85 (6):512-521, 2014.  PubMed link

13. McKee TC, Van Wyk AW, and Whitson EL. Natural Product Screening. In: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, edited by Figg DWand, and McLeod HL, Totoawa, NJ: Humana Press, 2014, p. 39-67.

14. Sunassee S, Ransom TT, Henrich CJ, Beutler JA, Covell DG, McMahon JB, and Gustafson KR. Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.  J.Nat.Prod. 77: 2475-2480, 2014. PubMed link

15. Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SFJ, O'Keefe BR, and Schneekloth, Jr JS. Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays. J.Am.Chem.Soc., 136: 8402-8410, 2014. PubMed link

16. Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes CA, Baldwin GS, Nikfarjam M, and He H. Glaucarubinone and gemcitibine synergistically reduce pancreatic cancer growth via inhibition of p21-activated kinases. Cancer Lett.  346 (2): 264-272, 2014. PubMed link

    
    

2013

1. Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, McMahon JB, O'Keefe BR, Chikwamba R, and Morris L. Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN. Virology 446 (1-2):66-76, 2013. PubMed link

2. Beutler JA. Natural Products as Tools for Discovering New Cancer Targets. In: Natural Products and Cancer Drug Discovery, edited by Koehn FE, New York: Humana Press, 2013, p. 213-237.

3. Devkota KP, Wilson J, Henrich CJ, McMahon JB, Reilly KM, and Beutler JA. Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth. J.Nat.Prod. 76 (1):59-63, 2013. PubMed link

4. Devkota KP, Covell DG, Ransom TT, McMahon JB, and Beutler JA. Growth inhibition of human colon carcinoma cells by sesquiterpenoids and tetralones of Zygogynum calothyrsum. J.Nat.Prod. 76 (4):710-714, 2013. PubMed link

5. Dossou KS, Devkota KP, Kavanogh P, Egan J, Beutler JA, and Moaddel R. Development and preliminary validation of a plate-based CB1/CB2 receptor functional assay. Anal.Biochem. 437 (2):137-143, 2013. PubMed link

6. Dossou KKS, Devkota KP, Morton C, Egan JM, Beutler JA, and Moaddel R. Identification of CB1/CB2 ligands from  Zanthoxylum bungeanum. J.Nat.Prod. 76 (11):2060-2064, 2013. PubMed link

7. Henrich CJ, Budhu A, Yu Z, Evans JR, Goncharova EI, Ransom TT, Wang XW, and McMahon JB. High-throughput screening for identification of inhibitors of EpCAM-dependent growth of hepatocellular carcinoma cells. Chem.Biol.Drug Des 82 (2):131-139, 2013. PubMed link

8. Henrich CJ and Beutler JA. Matching the power of high throughput screening to the chemical diversity of natural products. Nat.Prod.Repts. 30(10):1284-1298, 2013. PubMed link

9. Kanduluru AK, Banerjee P, Beutler JA, and Fuchs PL. A convergent total synthesis of the potent cephalostatin/ritterazine hybrid 25-epi ritterostatin GN1N. J.Org.Chem. 78 (18):9085-9092, 2013. PubMed link

10. Masaoka T, Chung S, Carboni P, Wilson JA, Beutler JA, Tocco G, and Le Grice SFJ. Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.  J.Med.Chem. 56:5436-5445, 2013. PubMed link

11. Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee JM, Trepel JB, Beutler JA, Linehan WM, and Neckers LM. Englerin A stimulates PKC theta to inhibit insulin signaling while simultaneously activating HSF1: A case of pharmacologically induced synthetic lethality. Cancer Cell 23 (2):228-237, 2013. PubMed link    CCR news

12. Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, and O'Keefe BR. Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus. PLoS One 8 (5):e64449, 2013. PubMed link

13. Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, and Porco, Jr JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a simplified tetrahydroxanthone analogue.  J.Org.Chem. 78 (15):7617-7626, 2013. PubMed link

2012

1. Akee RK, Ransom TT, Ratnayake R, McMahon JB, and Beutler JA. Chlorinated englerins with selective inhibition of renal cancer cell growth. J.Nat.Prod. 75 (3): 459-463, 2012. PubMed link
2. Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, and Morris L. The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells. Virology 423 (2):175-186, 2012. PubMed link

3. Beutler JA, Cragg GM, and Newman DJ. The National Cancer Institute and Natural Product Based Drug Discovery in Africa. In: Drug Discovery in Africa, edited by Chibale K, Davies-Coleman MT, and Masimirembwa C,Springer, 2012, p. 29-51.

4. Blees JS, Bokesch HR, Rubsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, and Brune B. Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase beta-TrCP1. PLoS One 7 (10):e46567, 2012. PubMed link
5. Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, and Gustafson KR. Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera. J.Nat.Prod. 75 (8):1490-1494, 2012. PubMed link
6. Dong S, Qin T, Hamel E, Beutler JA, and Porco, Jr JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienonesand their biological evaluation. J.Am.Chem.Soc. 134 (48):19782-19787, 2012. PubMed link
7. Giubellino A, Woldemichael GM, Sourbier C, Lizak MJ, Powers JF, Tischler AS, and Pacak K. Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging. Cancer Lett., 316: 46-52, 2012. PubMed Link

8. Hatanaka T, Ohzono S, Park M, Sakamoto K, Tsukamoto S, Sugita R, Ishitobi H, Mori T, Ito O, Sorajo K, Sugimura K, Ham S, and Ito Y. Human IgA-binding peptides selected from random peptide libraries: Affinity maturation and application in IgA purification. J.Biol.Chem.  287 (51):43126-43136, 2012. PubMed link

9. Henrich CJ, Thomas CL, Brooks AD, Booth NL, Lowery EM, Pompei RJ, McMahon JB, and Sayers TJ. Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis. Apoptosis.17 (1):79-89, 2012. PubMed link
10. McKee TC, Rabe D, Bokesch HR, Grkovic T, Whitson EL, Diyabalanage T, Van Wyk AW, Marcum SR, Gardella RS, Gustafson KR, Linehan WM, McMahon JB, and Bottaro DP. Inhibition of hypoxia inducible factor-2 transcription: Isolation of active modulators from marine sponges. J.Nat.Prod. 75 (9):1632-1636, 2012. PubMed link
11. Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, and Cushman M. Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. J.Med.Chem. 55 (9):4457-4478, 2012. PubMed link
12. Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, and McKee TC. Synergistic TRAIL Sensitizers from Barleria alluaudii and Diospyros maritima. J.Nat.Prod. 75 (3): 394-399, 2012. PubMed link
13. Woldemichael GM, Turbyville TJ, Vasselli JR, Linehan WM, and McMahon JB. Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A. Neoplasia. 14 (8):771-777, 2012. PubMed link

2011

1. Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, and Morris L. Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site. J.Virol. 85 (17):9039-9050, 2011. PubMed link
2. Best AM, Chang J, Dull AB, Beutler JA, and Martinez ED. Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell based assay. J.Biomed.Biotechnol. Article ID 868095, 2011. PubMed link
3. Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, and McKee TC. A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum. Chem.Pharm.Bull. 59 (9):1178-1179, 2011. PubMed Link
4. Chung S, Himmel DM, Jiang JK, Wojtak K, Baumann JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, and Le Grice SFJ. Synthesis, activity, and structural analysis of novel a-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J.Med.Chem. 54 (13):4462-4473, 2011. PubMed link
5. Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, and Beutler JA. Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius. J.Nat.Prod. 74 (3):374-377, 2011. PubMed Link
6. Diyabalanage T, Ratnayake R, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, and Gustafson KR. Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii. Bioorg.Med.Chem.Lett. 21 (15):4397-4399, 2011. PubMed link
7. Dong S, Cahill KJ, Kang M-I, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, and Porco, Jr. JA. Microwave-assisted reaction screening: Tandem retro-Diels-Alder/Diels-Alder cycloadditions of ortho-quinol dimers. J.Org.Chem. 76 (21):8944-8954, 2011. PubMed link
8. Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, and Helman LJ. Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening. J.Natl.Cancer Inst. 103 (12):962-978, 2011. PubMed link
9. Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, and Gustafson KR. Cryptocaryols A-H, alpha-Pyrone-Containing 1,3-Polyols from Cryptocarya sp. Implicated in Stabilizing the Tumor Suppressor Pdcd4. J.Nat.Prod. 74 (5):1015-1020, 2011.  PubMed Link
10. Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, Gustafson KR, and McKee TC. Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2alpha induced gene expression. Bioorg.Med.Chem.Lett. 21 (7):2113-2115, 2011. PubMed link
11. Kim JA, Wamiru A, McMahon JB, Le Grice SFJ, Beutler JA, and Kim YH. New monoterpene glycosides and phenolic compounds from Distylium racemosum, and their inhibitory activity against ribonuclease H. Bioorg.Med.Chem.Lett. 21 (10):2840-2844, 2011.PubMed link
12. Kouokam JC, Huskens D, Schols D, Johannemann A, Riedell SK, Walter W, Walker JM, Matoba N, O'Keefe BR, and Palmer KE. Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate. PLoS One 6 (8):e22635, 2011. PubMed link
13. O'Keefe BR. Anti-HIV microbicide development: Targeting the virus is the key. Future Virol. 6 (5):553-556, 2011.
14. Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, and McKee TC. Grassypeptolides F and G, Cyanobacterial Peptides from Lyngbya majuscula. J.Nat.Prod. 74 (8):1686-1691, 2011. PubMed link
15. Sando L, Troeira Henriques S, Foley F, Simonsen SM, Daly NL, Hall KN, Gustafson KR, Aguilar MI, and Craik DJ. A synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. Chembiochem. 12 (16):2456-2462, 2011. PubMed link
16. Sloman DL, Mitsaev B, Scully SS, Beutler JA, and Porco, Jr JA. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angew.Chem.Int.Ed.Engl.  50 (11): 2511-2515, 2011. PubMed link
17. Tai BH, Nhut ND, Nhiem NX, Quang TH, Ngan NTT, Luyen BTT, Huong TT, Wilson J, Beutler JA, Ban NK, Cuong NM, and Kim YH. An evaluation of the RNase H inhibitory properties of Vietnamese medicinal plant extracts and natural compounds. Pharmaceutical Biol. 49 (10):1046-1051, 2011. PubMed Link
18. Topczewski JJ, Callahan MP, Kodet JG, Inbarasu JD, Mente NR, Beutler JA, and Wiemer DF. Relevance of the C-5 position to schweinfurthin induced cytotoxicity. Bioorg.Med.Chem. 19:7570-7581, 2011. PubMed link
19. Van Wyk AW, Zuck KM, and McKee TC. Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum. J.Nat.Prod. 74 (5):1275-1280, 2011.  PubMed Link
20. Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, and Gustafson KR. Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2. J.Nat.Prod. 74 (2): 262-266, 2011. PubMed Link
21. Whitson EL, Pluchino KM, Hall MD, McMahon JB, and McKee TC. New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth. Org.Lett. 13 (13):3518-3521, 2011.  PubMed link
22. Woldemichael GM, Turbyville TJ, Linehan WM, and McMahon JB. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 71 (1):134-142, 2011. PubMed link
23. Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, Schmid T, and Shen B. Actinopolysporins A, B, C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora sp YIM90600. J.Nat.Prod. 74 (9):1990-1995, 2011. PubMed link

2010

1. K. B. Alexandre, E. S. Gray, B. E. Lambson, P. L. Moore, I. A. Choge, K. Mlisana, S. S. Karim, J. McMahon, B. O'Keefe, R. Chikwamba, and L. Morris. Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin. Virology 402 (1):187-196, 2010. PubMed link
2. J. S. Blees, T. Schmid, C. L. Thomas, A. R. Baker, L. Benson, J. R. Evans, E. I. Goncharova, N. H. Colburn, J. B. McMahon, and C. J. Henrich. Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4. J.Biomol.Screen. 15: 21-29, 2010. PubMed link
3. H. R. Bokesch, L. K. Cartner, R. W. Fuller, J. A. Wilson, C. J. Henrich, J. A. Kelley, K. R. Gustafson, J. B. McMahon, and T. C. McKee. Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids. Bioorg.Med.Chem.Lett. 20:3848-3850, 2010. PubMed link
4. G. G. Bushkin, D. M. Ratner, J. Cui, S. Banerjee, M. T. Duraisingh, C. V. Jennings, J. D. Dvorin, M. J. Gubbels, S. D. Robertson, M. Steffen, B. R. O'Keefe, P. W. Robbins, and J. Samuelson. Suggestive evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma. Eukaryot.Cell 9: 228-241, 2010. PubMed link
5. A. Carpentieri, D. M. Ratner, S. K. Ghosh, S. Banerjee, G. G. Bushkin, J. Cui, M. Lubrano, M. Steffen, C. E. Costello, B. R. O'Keefe, P. W. Robbins, and J. Samuelson. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryotic Cell 9 (11):1661-1668, 2010. PubMed link
6. S. Chung, M. Wendeler, J. W. Rausch, G. Beilhartz, M. Götte, B. R. O'Keefe, A. Bermingham, J. A. Beutler, S. Liu, X. Zhuang, and S. F. J. Le Grice. Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrob.Agents Chemother. 54 (9):3913-3921, 2010. PubMed link
7. A. Dull, E. Goncharova, G. Hager, and J. B. McMahon. Development of an image analysis screen for estrogen receptor alpha (ERalpha) ligands through measurement of nuclear translocation dynamics. J.Steroid Biochem.Mol.Biol. 122 (5):341-351, 2010. PubMed link
8. P. Klausmeyer, Q. N. Van, J. Jato, T. G. McCloud, and J. A. Beutler. Schweinfurthins I and J from Macaranga schweinfurthii. J.Nat.Prod. 73: 479-481, 2010. PubMed link
9. T. Moulaei, S. R. Shenoy, B. Giomarelli, C. Thomas, J. B. McMahon, Z. Dauter, B. R. O'Keefe, and A. Wlodawer. Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure 18 (9):1104-1115, 2010. PubMed link
10. T. Moulaei, O. Stuchlik, M. Reed, W. Yuan, J. Pohl, W. Lu, L. Haugh-Krumpe, B. R. O'Keefe, and A. Wlodawer. Topology of the disulfide bonds in the antiviral lectin scytovirin. Protein Sci. 19 (9):1649-1661, 2010. PubMed link
11. B. R. O'Keefe, B. Giomarelli, D. L. Barnard, S. R. Shenoy, P. K. Chan, J. B. McMahon, K. E. Palmer, B. W. Barnett, D. K. Meyerholz, C. L. Wohlford-Lenane, and P. B. McCray, Jr. Broad spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol.  84: 2511-2521, 2010.  PubMed link
12. N. Oku, K. Takada, R. W. Fuller, J. A. Wilson, M. L. Peach, L. K. Pannell, J. B. McMahon, and K. R. Gustafson. Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica. J.Am.Chem.Soc. 132 (30):10278-10285, 2010. PubMed link
13. S. Suzuki, E. Urano, C. Hashimoto, H. Tsutsumi, T. Nakahara, T. Tanaka, Y. Nakanishi, K. Maddali, Y. Han, M. Hamatake, K. Miyauchi, Y. Pommier, J. A. Beutler, W. Sugiura, H. Fuji, T. Hoshino, K. Itotani, W. Nomura, T. Narumi, N. Yamamoto, J. A. Komano, and H. Tamamura. Peptide HIV-1 integrase inhibitors from HIV-1 gene products. J.Med.Chem. 53:5356-5360, 2010. PubMed link
14. K. Takada, N. Imamura, K. R. Gustafson, and C. J. Henrich. Synthesis and structure-activity relationship of botryllamides that block the ABCG2 multidrug transporter. Bioorg.Med.Chem.Lett.  20: 1330-1333, 2010. PubMed link
15. T. J. Turbyville, D. B. Gürsel, R. G. Tuskan, J. C. Walrath, C. Lipshutz, S. J. Lockett, D. F. Wiemer, J. A. Beutler, and K. M. Reilly. Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in an NF1-GRD dependent manner. Mol.Cancer Ther.  9: 1234-1243, 2010. PubMed link
16. N. Ulrich, J. G. Kodet, N. R. Mente, C. H. Kuder, J. A. Beutler, R. J. Hohl, and D. F. Wiemer. Structural analogues of schweinfurthin F: Probing the steric, electronic and hydrophobic properties of the D-ring substructure. Bioorg.Med.Chem. 18: 1676-1683, 2010. PubMed link
17. E. L. Whitson, C. L. Thomas, C. J. Henrich, T. J. Sayers, J. B. McMahon, and T. C. McKee. Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers. J.Nat.Prod. 73 (12):2013-2018, 2010. PubMed link

2009

1. J. A. Beutler, M.-I. Kang, F. Robert, J. A. Clement, J. Pelletier, N. H. Colburn, T. C. McKee, E. Goncharova, J. B. McMahon, and C. J. Henrich. Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. J.Nat.Prod. 72(3): 503-506, 2009. PubMed link
2. J. A. Beutler. Natural products as a foundation for drug discovery. Curr. Protocols Pharmacol. 46: 9.11.1-9.11.21, 2009. PubMed link
3. N. L. Booth, T. J. Sayers, A. D. Brooks, C. F. Thomas, K. Jacobsen, E. I. Goncharova, J. B. McMahon and C. J. Henrich. A cell-based high-throughput screen to identify synergistic TRAIL sensitizers. Cancer Immunol.Immunother. 58 (8):1229-1244, 2009.  PubMed link
4. G.M. Cragg, J.A. Beutler, W.P. Jones, eds. The American Society of Pharmacognosy. 50 Years of Progress in Natural Progress Research. 1959-2009, American Society of Pharmacognosy, 2009. 280 pages. Online publication
5. C. Cui, J. Jaja, T. Turbyville, J. Beutler, P. Gudla, K. Nandy, and S. Lockett. Quantifying the astrocytoma cell response to candidate pharmaceutical from F-actin image analysis. Conf.Proc.IEEE Eng.Med.Biol.Soc. 2009:5768-5771, 2009. PubMed link
6. S. Dong, E. Hamel, R. Bai, D. G. Covell, J. A. Beutler, and J. A. Porco, Jr. Enantioselective synthesis of -chamaecypanone C, a novel microtubule inhibitor. Angew.Chem.Int.Ed.Engl. 48 (8): 1494-1497, 2009. PubMed link
7. C. J. Henrich, R. W. Robey, K. Takada, H. R. Bokesch, S. E. Bates, S. Shukla, S. V. Ambudkar, J. B. McMahon, and K. R. Gustafson. Botryllamides: natural product inhibitors of ABCG2. ACS Chem.Biol. 4 (8):637-647, 2009. PubMed link
8. M. I. Kang, C. J. Henrich, H. R. Bokesch, K. R. Gustafson, J. B. McMahon, A. R. Baker, M. R. Young, and N. H. Colburn. A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits". Mol. Cancer Ther. 8 (3):571-581, 2009. PubMed link
9. Y. Liu, J. R. Carroll, L. A. Holt, J. McMahon, B. Giomarelli, and G. Ghirlanda. Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin. Biopolymers 92 (3):194-200, 2009. PubMed link
10. B. R. O'Keefe, F. Vojdani, V. Buffa, R. J. Shattock, D. C. Montefiori, J. Bakke, J. Mirsalis, A. L. d'Andrea, S. D. Hume, B. Bratcher, C. J. Saucedo, J. B. McMahon, G. P. Pogue, and K. E. Palmer. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proc.Natl.Acad.Sci U S A 106 (15):6099-6104, 2009. PubMed link
11. R. Ratnayake, D. G. Covell, T. T. Ransom, K. R. Gustafson, and J. A. Beutler. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. Org.Lett. 11 (1):57-60, 2009. PubMed link
12. M. Wendeler, G. L. Beilhartz, M. Götte, J. A. Beutler, and S. F. J. Le Grice. Human immunodeficiency virus ribonuclease H: Continuing the search for small molecule antagonists. HIV Therapy  3 (1):39-53, 2009. 
13. I. E. Wrona, J. T. Lowe, T. J. Turbyville, T. R. Johnson, J. Beignet, J. A. Beutler, and J. S. Panek. Synthesis of a 35-member stereoisomer library of bistramide A: Evaluation of effects on actin state, cell cycle and tumor cell growth. J.Org.Chem. 74 (5): 1897-1916, 2009. PubMed link
14. S. M. Yun, T. Moulaei, D. Lim, J. K. Bang, J. E. Park, S. R. Shenoy, F. Liu, Y. H. Kang, C. Liao, N. K. Soung, S. Lee, D. Y. Yoon, Y. Lim, D. H. Lee, A. Otaka, E. Appella, J. B. McMahon, M. C. Nicklaus, T. R. Burke, Jr., M. B. Yaffe, A. Wlodawer, and K. S. Lee. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct.Mol Biol. 16 (8):876-882, 2009. PubMed link

2008

1. H. R. Bokesch, A. Wamiru, S. F. J. Le Grice, J. A. Beutler, T. C. McKee, and J. B. McMahon. New HIV-1 inhibitory ribonuclease H phenolic glycosides from Eugenia hiemalis. J.Nat.Prod. 71 (9):1634-1636, 2008. PubMed link
2. J. A. Clement, J. Kitagaki, Y. Yang, C. J. Saucedo, B. R. O'Keefe, A. M. Weissman, T. C. McKee, and J. B. McMahon. Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. Bioorg.Med.Chem. 16 (23):10022-10028, 2008. PubMed link
3. D. C. Ireland, C. K. Wang, J. A. Wilson, K. R. Gustafson, and D. J. Craik. Cyclotides as natural anti-HIV agents. Biopolymers 90 (1):51-60, 2008.PubMed link
4. C. Marchand, J. A. Beutler, A. Wamiru, S. R. Budihas, U. Mollmann, L. Heinisch, J. W. Mellors, S. F. Le Grice, and Y. Pommier. Madurahydroxylactone derivatives as dual inhibitors of HIV-1 integrase and RNase H. Antimicrob.Agents Chemother. 52 (1):361-364, 2008. PubMed link
5. A. M. Mayer and K. R. Gustafson. Marine pharmacology in 2005-2006: Antitumor and cytotoxic compounds. Eur.J.Cancer  44 (16):2357-2387, 2008. PubMed link
6. C. A. Sasiela, D. H. Stewart, J. Kitagaki, Y. Safiran, Y. Yang, A. M. Weissman, P. Oberoi, I. Davydov, E. Goncharova, J. A. Beutler, B. R. O'Keefe, and J. B. McMahon. Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high throughput electrochemiluminescent screen. J.Biomol.Screen. 13 (3):229-237, 2008. PubMed link
7. D. F. Smee, K. W. Bailey, M. H. Wong, B. R. O'Keefe, K. R. Gustafson, V. P. Mishin, and L. V. Gubareva. Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N. Antiviral Res. 80 (3):266-271, 2008. PubMed link
8. C. K. Wang, M. L. Colgrave, K. R. Gustafson, D. C. Ireland, U. Goransson, and D. J. Craik. Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. J Nat Prod. 71 (1):47-52, 2008. PubMed link
9. A. M. Weissman, Y. Yang, J. Kitagaki, C. A. Sasiela, J. A. Beutler, and B. R. O'Keefe. Inhibiting Hdm2 and ubiquitin-activating enzyme: Targeting the ubiquitin conjugating system in cancer. Ernst.Schering.Found.Symp.Proc. (1):171-190, 2008. PubMed link
10. M. Wendeler, H.-F. Lee, A. Bermingham, J. T. Miller, O. Chertov, M. K. Bona, N. S. Baichoo, M. Ehteshami, J. A. Beutler, B. R. O'Keefe, M. Götte, M. Kvaratskhelia, and S. F. J. Le Grice. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.  ACS Chem.Biol. 3 (10):635-644, 2008. PubMed link

2007

1. N. T. Dat, K. H. Bae, A. Wamiru, J. B. McMahon, S. F. J. Le Grice, M. Bona, J. A. Beutler, and Y. H. Kim. A dimeric lactone from Ardisia japonica which inhibits HIV-1 and HIV-2 ribonuclease H. J.Nat.Prod. 70 (5):839-841, 2007. PubMed link
2. P. Emau, B. Tian, B. R. O'Keefe, T. Mori, J. B. McMahon, K. E. Palmer, Y. Jiang, G. Bekele, and C. C. Tsai. Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide. J Med Primatol. 36 (4-5):244-253, 2007. PubMed link
3. R. Fromme, Z. Katilene, B. Giomarelli, F. Bogani, J. McMahon, T. Mori, P. Fromme, and G. Ghirlanda. A monovalent mutant of cyanovirin-N provides insight into the role of multiple interactions with gp120 for antiviral activity. Biochemistry 46:9199-9207, 2007. PubMed link
4. B. Giomarelli, A. V. Washington, M. Chisholm, L. Quigley, J. B. McMahon, T. Mori, and D. W. McVicar. Inhibition of thrombin-induced platelet aggregation using human single chain Fv antibodies specific for TREM-like transcript-1. Thrombosis & Hemostasis 97 (6):955-963, 2007. PubMed link
5. C. J. Henrich, E. I. Goncharova, J. A. Wilson, R. S. Gardella, T. R. Johnson, J. B. McMahon, K. Takada, H. R. Bokesch, and K. R. Gustafson. Natural products active in aberrant c-Kit signaling. Chemical Biology & Drug Design 69:321-330, 2007. PubMed link
6. C. J. Henrich, R. W. Robey, H. R. Bokesch, S. E. Bates, S. Shukla, S. V. Ambudkar, M. Dean, and J. B. McMahon. New inhibitors of ABCG2 identified by high-throughput screening. Mol.Cancer Ther. 6 (12):3271-3278, 2007. PubMed link
7. L. R. Krumpe, K. M. Schumacher, J. B. McMahon, L. Makowski, and T. Mori. Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library. BMC Biotechnol. 7:65, 2007. PubMed link
8. R. L. McFeeters, C. Xiong, B. R. O'Keefe, H. R. Bokesch, J. B. McMahon, D. M. Ratner, R. Castelli, P. H. Seeberger, and R. A. Byrd. The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors. J.Mol.Biol. 369 (2):451-461, 2007. PubMed link
9. N. Mente, A. J. Wiemer, J. D. Neighbors, J. A. Beutler, R. J. Hohl, and D. F. Wiemer. Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series. Bioorg.Med.Chem.Lett. 17:911-915, 2007. PubMed link
10. T. L. Meragelman, R. H. Willis, G. M. Woldemichael, A. Heaton, P. T. Murphy, K. M. Snader, D. J. Newman, R. V. Soest, M. R. Boyd, J. H. Ii, and T. C. McKee. Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia. J. Nat. Prod. 70 (7): 1133-1138, 2007. PubMed link
11. T. Moulaei, I. Botos, N. E. Ziolkowska, H. R. Bokesch, L. R. Krumpe, T. C. McKee, B. R. O'Keefe, Z. Dauter, and A. Wlodawer. Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Sci. 16 (12):2756-2760, 2007. PubMed link
12. K. M. Ruocco, E. I. Goncharova, M. R. Young, N. H. Colburn, J. B. McMahon, and C. J. Henrich. A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1. J Biomol.Screen.  12 (1):133-139, 2007. PubMed link

13. D.F. Smee, M.K. Wandersee, M.B. Checketts, B.R. O'Keefe, C. Saucedo, M.R. Boyd, V.P. Mishin, L.V. Gubareva. Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor. Antivir Chem Chemother.18(6):317-27, 2007. PubMed link

14. K. Takada, A. Bermingham, B. R. O'Keefe, A. Wamiru, J. A. Beutler, S. F. J. Le Grice, J. Lloyd, K. R. Gustafson, and J. B. McMahon. A new HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis. J.Nat.Prod. 70 (10):1647-1649, 2007. PubMed link
15. K. Takada, B. W. Choi, M. A. Rashid, W. R. Gamble, J. H. Cardellina, Q. N. Van, J. R. Lloyd, J. B. McMahon, and K. R. Gustafson. Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species. J Nat Prod. 70 (3):428-431, 2007. PubMed link
16. Y. Yang, J. Kitagaki, R. M. Dai, Y. C. Tsai, K. L. Lorick, R. L. Ludwig, S. A. Pierre, J. P. Jensen, I. V. Davydov, P. Oberoi, C.-C. Li, J. H. Kenten, J. A. Beutler, K. H. Vousden, and A. M. Weissman. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res. 67 (19):9472-9481, 2007. PubMed link
17. N. E. Ziolkowska, S. R. Shenoy, B. R. O'Keefe, and A. Wlodawer. Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine. Protein Sci. 16 (7):1485-1489, 2007. PubMed link
18. N. E. Ziolkowska, S. R. Shenoy, B. R. O'Keefe, J. B. McMahon, K. E. Palmer, R. A. Dwek, M. R. Wormald, and A. Wlodawer. Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins 67 (3):661-670, 2007. PubMed link

2006

1. J. A. Beutler, J. Jato, G. M. Cragg, D. F. Wiemer, J. D. Neighbors, M. S. Salnikova, M. G. Hollingshead, D. Scudiero, and T. G. McCloud. The schweinfurthins: Issues in development of a plant-based anticancer lead. In:  Medicinal and Aromatic Plants.  Agricultural, Commercial, Ecological, Legal, Pharmacological and Social Aspects, edited by R. J. Bogers, L. Craker, and D. Lange, Dordrecht, The Netherlands:Springer, 2006, p. 301-309.
2. B. Giomarelli, K. M. Schumacher, T. E. Taylor, R. C. Sowder, J. L. Hartley, J. B. McMahon, and T. Mori. Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture. Protein Expr.Purif. 47 (1):194-202, 2006. PubMed link
3. F. Helle, C. Wychowski, N. Vu-Dac, K. R. Gustafson, C. Voisset, and J. Dubuisson. Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans. J.Biol.Chem. 281 (35):25177-25183, 2006.
4. C. J. Henrich, H. R. Bokesch, M. Dean, S. E. Bates, R. W. Robey, E. I. Goncharova, J. A. Wilson, and J. B. McMahon. A high-throughput cell-based assay for inhibitors of ABCG2 activity. J.Biomol.Screen. 11:176-183, 2006. PubMed link
5. Y. H. Kim, E. J. Park, M. H. Park, U. Badarch, G. Woldemichael, and J. A. Beutler. Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2. Biol.Pharm.Bull. 29 (10):2140-2142, 2006. PubMed link
6. L. R. Krumpe, A. J. Atkinson, G. W. Smythers, A. Kandel, K. M. Schumacher, J. B. McMahon, L. Makowski, and T. Mori. T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries. Proteomics. 6 (15):4210-4222, 2006. PubMed link
7. L. R. Krumpe and T. Mori. The use of phage-displayed peptide libraries to develop tumor-targeting drugs. Int.J.Peptide Res.Therapeut. 12:79-91, 2006.
8. M. C. Liang, S. Bardhan, E. A. Pace, D. Rosman, J. A. Beutler, J. A. Porco, Jr., and T. D. Gilmore. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity. Biochem.Pharmacol. 71 (5):634-645, 2006. PubMed link
9. E. D. Martinez, A. B. Dull, J. A. Beutler, and G. L. Hager. High content fluorescence-based screening for epigenetic modulators. Methods Enzymol. 414:21-36, 2006. PubMed link
10. A. M. Mayer and K. R. Gustafson. Marine pharmacology in 2003-2004: anti-tumour and cytotoxic compounds. Eur.J Cancer 42 (14):2241-2270, 2006. PubMed link
11. J. D. Neighbors, M. S. Salnikova, J. A. Beutler, and D. F. Wiemer. Synthesis and structure activity studies of schweinfurthin B analogs:  Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity. Bioorg.Med Chem. 14:1771-1784, 2006. PubMed link
12. G. M. Woldemichael, J. R. Vasselli, R. S. Gardella, T. C. McKee, W. M. Linehan, and J. B. McMahon. Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression. J.Biomol.Screen. 11 (6):678-687, 2006. PubMed link
13. C. Xiong, B. R. O'Keefe, I. Botos, A. Wlodawer, and J. B. McMahon. Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expr.Purif. 46 (2):233-239, 2006.PubMed link
14. C. Xiong, B. R. O'Keefe, R. A. Byrd, and J. B. McMahon. Potent anti-HIV activity of scytovirin domain 1 peptide. Peptides 27 (7):1668-1675, 2006. PubMed link
15. N. E. Ziolkowska, B. R. O'Keefe, T. Mori, C. Zhu, B. Giomarelli, F. Vojdani, K. E. Palmer, J. B. McMahon, and A. Wlodawer. Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure 14 (7):1127-1135, 2006. PubMed link

2005

1. S. R. Budihas, I. I. Gorshkova, S. A. Gaidamakov, A. Wamiru, M. K. Bona, M. A. Parniak, R. C. Crouch, J. B. McMahon, J. A. Beutler, and S. F. J. Le Grice. Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Nucl.Acids Res. 33 (4):1249-1256, 2005, doi:10.1093/nar/gki268. PubMed link
2. I. Calis, H. Kirmizibekmez, J. A. Beutler, A. A. Dönmez, F. N. Yalcin, E. Kilic, M. Özalp, P. Rüedi, and D. Tasdemir. Secondary metabolites of Phlomis viscosa and their biological activities. Turkish J.Chem. 29 (1):71-81, 2005. 
3. B. Chen, M. L. Colgrave, N. L. Daly, K. J. Rosengren, K. R. Gustafson, and D. J. Craik. Isolation and characterization of novel cyclotides from Viola hederaceae: Solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide. J.Biol.Chem.  280 (23):22395-22405, 2005, doi:10.1074/jbc.M501737200. PubMed link
4. M. G. Dijoux, P. C. Schnabel, Y. F. Hallock, J. L. Boswell, T. R. Johnson, J. A. Wilson, C. M. Ireland, R. W. M. Van Soest, M. R. Boyd, L. R. Barrows, and J. H. Cardellina, II. Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya. Bioorg.Med.Chem. 13:6035-6044, 2005, doi: 10.1016/j.bmc.2005.06.019. PubMed link
5. A. Koltay, N. L. Daly, K. R. Gustafson, and D. J. Craik. Structure of circulin B and implications for antimicrobial activity of the cyclotides. Int.J.Peptide Res.Therapeut. 11:51-58, 2005, doi:10.1007/s10989-004-1722-2. 
6. E. D. Martinez, G. V. Rayasam, A. B. Dull, D. A. Walker, and G. L. Hager. An estrogen receptor chimera senses ligands by nuclear translocation. J.Steroid Biochem.Mol.Biol. 97 (4):307-321, 2005, doi: 10.1016/j.jsbmb.2005.06.033. PubMed link
7. J. B. McMahon, K. R. Gustafson, and C. J. Henrich. Molecular-targeted drug screening at the NCI Center for Cancer Research. AACR Education Book.  125-129, 2005.
8. T. Mori, B. R. O'Keefe, R. C. Sowder, S. Bringans, R. Gardella, S. Berg, P. Cochran, J. A. Turpin, R. W. Buckheit, Jr., J. B. McMahon, and M. R. Boyd. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. J.Biol.Chem. 280 (10):9345-9353, 2005, doi: 10.1074/jbc.M411122200. PubMed link
9. J. D. Neighbors, J. A. Beutler, and D. F. Wiemer. Synthesis of nonracemic 3-deoxyschweinfurthin B. J.Org.Chem. 70 (3):925-931, 2005, doi: 10.1021/jo048444r. PubMed link
10. D. F. Nellis, S. L. Giardina, G. M. Janini, S. R. Shenoy, J. D. Marks, R. Tsai, D. C. Drummond, K. Hong, J. W. Park, T. F. Ouellette, S. C. Perkins, and D. B. Kirpotin. Preclinical manufacture of anti-HER2 liposome-inserting, scFv-PEG-lipid conjugate. 2. Conjugate micelle identity, purity, stability, and potency analysis. Biotechnol.Prog. 21 (1):221-232, 2005, doi: 10.1021/bp049839z. PubMed link
11. Newman, D. J.; Cragg, G. M. and O'Keefe, B. R.:  Biopharmaceutical drugs from natural sources. Part II, Chapter 4, p.451-496. Modern Biopharmaceuticals: Design, Development and Optimization.  J. Knablein, Ed., Wiley-VCH Verlag GmbH & Col., 2005.
12. N. Oku, R. Krishnamoorthy, A. G. Benson, R. L. Ferguson, M. A. Lipton, L. R. Phillips, K. R. Gustafson, and J. B. McMahon. Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B. J.Org.Chem. 70 (17):6842-6847, 2005, doi: 10.1021/jo0508853. PubMed link
13. M. Witvrouw, V. Fikkert, A. Hantson, C. Pannecouque, B. R. O'Keefe, J. McMahon, L. Stamatatos, E. De Clercq, and A. Bolmstedt. Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. J.Virol. 79 (12):7777-7784, 2005, doi: 10.1128/JVI.79.12.7777-7784.2005. PubMed link

2004

1. Adams EW, Ratner DM, Bokesch HR, McMahon JB, O'Keefe BR, Seeberger PH. Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions. Chem Biol 11: 875-881, 2004, doi: 10.1016/j.chembiol.2004.04.010. PubMed link
2. Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ. Solution structure of the cyclotide palicourein: Implications for the development of a pharmaceutical framework. Structure 12: 85-94, 2004, doi: 10.1016/j.str.2003.11.019. PubMed link
3. Bokesch HR, Charan RD, Meragelman KM, Gardella RS, Beutler JA, O'Keefe BR, McKee TC, McMahon JB. Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea. FEBS Lett 567: 287-290, 2004, doi: 10.1016/j.febslet.2004.04.085. PubMed link
4. Bringans SD, O'Keefe BR, Bray M, Whitehouse CA, Boyd MR. Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma. Anal Bioanal Chem 380: 269-274, 2004, doi: 10.1007/s00216-004-2786-8. PubMed link
5. Chan KC, Budihas SR, Le Grice SFJ, Parniak MA, Crouch RJ, Gaidamakov SA, Isaaq HJ, Wamiru A, McMahon JB, Beutler JA. A capillary electrophoretic assay for ribonuclease H activity. Anal Biochem 331: 296-302, 2004, doi: 10.1016/j.ab.2004.05.017. PubMed link
6. Charan RD, McKee TC, Boyd MR. Cytotoxic alkaloids from the marine sponge Thorectandra sp. Nat Prod Res 18: 225-229, 2004. PubMed link
7. Daly NL, Gustafson KR, Craik DJ. The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1. FEBS Lett 574: 69-72, 2004, doi: 10.1074/jbc.M501737200. PubMed link
8. Gustafson KR, McKee TC, Bokesch HR. Anti-HIV cyclotides. Curr Protein Pept Sci 5: 331-340, 2004, doi: 10.2174/1389203043379468. PubMed link
9. Han Z, Simpson JT, Fivash MJ, Fisher R, Mori T. Identification and characterization of peptides that bind to cyanovirin-N, a potent human immunodeficiency virus-inactivating protein. Peptides 25: 551-561, 2004, doi: 10.1016/j.peptides.2004.02.018. PubMed link
10. Hess S, Gustafson KR, Milanowski DJ, Alvira E, Lipton MA, Pannell LK. Chirality determination of unusual amino acids using precolumn derivatization and liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr A 1035: 211-219, 2004, doi: 10.1016/j.chroma.2004.02.068. PubMed link
11. Lopanik N, Gustafson KR, Lindquist N. Structure of bryostatin 20: A symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina. J Nat Prod 67: 1412-1414, 2004, doi: 10.1021/np040007k. PubMed link
12. Mayer AM, Gustafson KR. Marine pharmacology in 2001-2: antitumour and cytotoxic compounds. Eur J Cancer 40: 2676-2704, 2004, doi: 10.1016/j.ejca.2004.09.005. PubMed link
13. Meragelman KM, McKee TC, McMahon JB. Monanchorin, a bicyclic alkaloid from the sponge Monanchora unguiculata. J Nat Prod 67: 1165-1167, 2004, doi: 10.1021/np030434i. PubMed link
14. Milanowski DJ, Gustafson KR, Kelley JA, McMahon JB. Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinolines from the marine bryozoan Caulibugula intermis. J Nat Prod 67: 70-73, 2004, doi: 10.1021/np030378l. PubMed link
15. Milanowski DJ, Rashid MA, Gustafson KR, O'Keefe BR, Nawrocki JP, Pannell LK, Boyd MR. Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri. J Nat Prod 67: 441-444, 2004, doi: 10.1021/np030336x. PubMed link
16. Milanowski DJ, Gustafson KR, Rashid MA, Pannell LK, McMahon JB, Boyd MR. Gymnangiamide, a cytotoxic pentapeptide from the marine hydroid Gymnangium regae. J Org Chem 69: 3036-3042, 2004, doi: 10.1021/jo0303113. PubMed link
17. Mori T. Cancer-specific ligands identified from screening of peptide-display libraries. Curr Pharm Des 10: 2335-2343, 2004, doi: 10.2174/1381612043383944. PubMed link
18. Oku N, Gustafson KR, Cartner LK, Wilson JA, Shigematsu N, Hess S, Pannell LK, Boyd MR, McMahon JB. Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi. J Nat Prod 67: 1407-1411, 2004, doi: 10.1021/np040003f. PubMed link
19. Pai HV, Kommaddi RP, Chinta SJ, Mori T, Boyd MR, Ravindranath V. A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. J Biol Chem 279: 27383-27389, 2004, doi: 10.1074/jbc.M402337200. PubMed link
20. Ratner DM, Adams EW, Su J, O'Keefe BR, Mrksich M, Seeberger PH. Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides. Chembiochem 5: 379-383, 2004, doi: 10.1002/cbic.200300804. PubMed link
21. Tsai CC, Emau P, Jiang YH, Agy MB, Shattock RJ, Schmidt A, Morton WR, Gustafson KR, Boyd MR. Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models. AIDS Res Hum Retroviruses 20: 11-18, 2004, doi: 10.1089/088922204322749459. PubMed link

2003

1. Adams EW, Ueberfeld J, Ratner DM, O'Keefe BR, Walt DR, Seeberger PH. Encoded fiber-optic microsphere arrays for probing protein-carbohydrate interactions. Angew Chem Int Ed Engl 42: 5317-5320, 2003, doi: 10.1002/anie.200351286. PubMed link
2. Barrientos LG, O'Keefe BR, Bray M, Sanchez A, Gronenborn AM, Boyd MR. Cyanovirin-N binds to the viral surface glycoprotein GP1,2 and inhibits infectivity of Ebola virus. Antiviral Res 58: 47-56, 2003, doi: 10.1016/S0166-3542(02)00183-3. PubMed link
3. Beutler JA, McKee TC. Novel marine and microbial natural product inhibitors of vacuolar ATPase. Curr Med Chem 10: 787-796, 2003, doi: 10.2174/0929867033457827. PubMed link
4. Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC, Turpin J, Watson K, Buckheit RW, Jr., Boyd MR. A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry 42: 2578-2584, 2003, doi: 10.1021/bi0205698. PubMed link
5. Bowman EJ, Gustafson KR, Bowman BJ, Boyd MR. Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases. J Biol Chem 278: 44147-44152, 2003, doi: 10.1074/jbc.M306595200. PubMed link
6. Chen X, Beutler JA, Loehfelm A, Yang L, Dong H-F, Chertov O, Oppenheim JJ, Howard OMZ. Tannic acid is a novel CXCL12 (SDF1)/CXCR4 inhibitor with potential anti-angiogenic activity. Clin Cancer Res 9: 3115-3123, 2003, PubMed link
7. Erickson KL, Gustafson KR, Milanowski DJ, Pannell LK, Klose JR, Boyd MR. Myriastramides A-C, new modified cyclic peptides from the Phillipines marine sponge Myriastra clavosa. Tetrahedron 59: 10231-10238, 2003, doi: 10.1021/np020193z. PubMed link
8. O'Keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Mori T, Blakeslee D, Buckheit R, Boyd MR. Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrob Agents Chemother 47: 2518-2525, 2003, doi: 10.1128/aac.47.8.2518-2525.2003. PubMed link
9. Parniak MA, Min KL, Budihas SR, Le Grice SFJ, Beutler JA. A fluorescence-based high-throughput screening assay for inhibitors of HIV-1 reverse transcriptase associated ribonuclease H activity. Anal Biochem 322: 33-39, 2003, doi: 10.1016/j.ab.2003.06.001. PubMed link
10. CTsai CC, Emau P, Jiang Y, Tian B, Morton WR, Gustafson KR, Boyd MR. Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques. AIDS ResHumRetroviruses 19: 535-541, 2003, doi: 10.1089/088922203322230897. PubMed link

2002

1. Barrientos LG, Louis JM, Botos I, Mori T, Han ZZ, O'Keefe BR, Boyd MR, Gronenborn AM. The domain-swapped dimer of cyanovirin-N is in a metastable folding intermediate. Reconciliation of X-ray and NMR structures. Structure 10: 673-686, 2002, doi: 10.1016/S0969-2126(02)00758-X. PubMed link
2. Barrientos LG, Louis JM, Hung J, Smith TH, O'Keefe BR, Gardella RS, Mori T, Boyd MR, Gronenborn AM. Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N. Proteins: Structure, Function and Genetics 46: 153-160, 2002, doi: 10.1002/prot.10024. PubMed link
3. Beutler JA, McMahon JB, Johnson TR, O'Keefe BR, Buzzell RA, Robbins D, Gardella R, Wilson J, Boyd MR. High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41. J Biomolecular Screening 7: 105-110, 2002, doi: 10.1177/108705710200700202. PubMed link
4. Bokesch HR, Stull AC, Pannell LK, McKee TC, Boyd MR. A new pentacyclic sulfated hydroquinone from the marine sponge Haliclona sp. Tet Lett 43: 3079-3081, 2002, doi: 10.1016/S0040-4039(02)00355-6.  
5. BBotos I, Mori T, Cartner LK, Boyd MR, Wlodawer A. Domain-swapped structure of a mutant of cyanovirin-N. Biochem Biophys Res Commun 294: 184-190, 2002, doi: 10.1016/S0006-291X(02)00455-2. PubMed link
6. Botos I, O'Keefe BR, Shenoy SR, Cartner LK, Ratner DM, Seeberger PH, Boyd MR, Wlodawer A. Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high-mannose oligosaccharides. J Biol Chem 277: 34336-34342, 2002, doi: 10.1074/jbc.M205909200. PubMed link

7. Charan RD, McKee TC, Boyd MR. Thorectandrols C, D, and E, new sesterterpenes from the marine sponge Thorectandra sp. J Nat Prod 65: 492-495, 2002, doi: 10.1021/np010439k. PubMed link

8. Charan RD, McKee TC, Gustafson KR, Pannell LK, Boyd MR. Thorectandramine, a novel b-carboline alkaloid from the marine sponge Thorectandra sp. Tet Lett 43: 5201-5204, 2002, doi: 10.1016/S0040-4039(02)01023-7. 
9. Erickson KL, Gustafson KR, Pannell LK, Beutler JA, Boyd MR. New dimeric macrolide glycosides from the marine sponge Myriastra clavosa. J Nat Prod 65: 1303-1306, 2002, doi: 10.1021/np020193z. PubMed link
10. Giomarelli B, Mori T, Provvedi R, Meacci F, Maggi T, McMahon JB, Gardella R, Medaglini D, Boyd MR, Pozzi G. The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1. AIDS 16: 1356, 2002, doi: 10.1097/00002030-200207050-00006. PubMed link
11. Han ZZ, Xiong CY, Mori T, Boyd MR. Discovery of a stable dimeric mutant of cyanovirin-N (CV-N) from a T7 phage-displayed CV-N mutant library. Biochem Biophys Res Comm 292: 1036-1043, 2002, doi: 10.1006/bbrc.2002.6741. PubMed link
12. Meragelman KM, West LM, Northcote PT, Pannell LK, McKee TC, Boyd MR. Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp. J Org Chem 67: 6671-6677, 2002, doi: 10.1021/jo020120k. PubMed link
13. Mori T, Barrientos LG, Han ZZ, Gronenborn AM, Turpin JA, Boyd MR. Functional homologs of cyanovirin-N amenable to mass production in prokaryotic and eukaryotic hosts. Protein Expr Purif 26: 42-49, 2002, doi: 10.1016/S1046-5928(02)00513-2. PubMed link
14. Pettit GR, Ducki S, Tan R, Gardella RS, McMahon JB, Boyd MR, Pettit GRI, Blumberg PM, Lewin NE, Doubek DL, Tackett LP, Williams MD. Isolation and structure of pedilstatin from a Republic of Maldives Pedilanthus sp. J Nat Prod 65: 1262-1265, 2002, doi: 10.1021/np020115b. PubMed link
15. Rashid MA, Gustafson KR, Crouch RC, Groweiss A, Pannell LK, Van QN, Boyd MR. Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin A, a new antitumor macrolide lactam from the sponge Poecillastra species. Org Lett 4: 3293-3296, 2002, doi: 10.1021/ol026564k. PubMed link
16. Shenoy SR, Barrientos LG, Ratner DM, O'Keefe BR, Seeberger PH, Gronenborn AM, Boyd MR. Multisite and multivalent binding between cyanovirin-N and branched oligomannosides: Calorimetric and NMR characterization. Chem Biol 9: 1109-1118, 2002, doi: 10.1016/S1074-5521(02)00237-5. PubMed link

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