Once a compound has been purified, its structure must be determined. The primary tool we use for organic molecules is the nuclear magnetic resonance spectrometer (NMR). The sample is placed in a large, superconducting magnetic field and radio waves are used to probe the structure. Many types of experiment can establish the connectivity between atoms in the pure compound and even the three-dimensional structure. We have two NMR units, 500 MHz and 600 MHz. The larger unit has a cryprobe which increases the sensitivity substantially.


Last updated by Beutler, John (NIH/NCI) [E] on May 03, 2012