2024
2023
Borhani, SG, Levine, MZ, Krumpe, L,H, Wilson, J, Henrich, CJ, O'Keefe, BR, Lo, DC, Sittampalam, GS, Godfrey, AG, Lunsford, RD, Mangalampalli, V, Tao, D, LeClair, CA, Thole, AP, Frey, D, Swartz, J, Rao, G, An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics. N Biotechnol 76, 13-22, 2023. doi:10.1016/j.nbt.2023.04.003 PubMed link
Di, X, Hardardottir,I , Freysdottir, J, Wang, D, Gustafson, KR, Omarsdottir, S, Molinski, TF., Geobarrettin D, a rare herbipoline-containing 6-bromoindole alkaloid from Geodia barretti. Molecules 28, 2937, 2023. doi: 10.3390/molecules28072937 PubMed link
Evans, JR, Akee, RK, Chanana, S, McConachie, GD, Thornburg, CC, Grkovic, T, O'Keefe, BR. National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 screening data of natural product samples with artificial neural networks. ACS Omega 8, 9250-9256, 2023. doi:10.1021/acsomega.2c07416 PubMed link
Muñoz-Basagoiti, J, Monteiro, FLL, Krumpe, LRH, Armario-Najera, V, Shenoy, SR, Perez-Zsolt, D, Westgarth, HJ, Villorbina, G, Bomfim, LM, Räich-Regué, D, Nogueras, L, Henrich, CJ, Gallemi, M, Moreira, FRR, Torres, P, Wilson, J, D'Arc, M, Marfil, S, Herlinger, AL, Pradenas, E, Higa, LM, Portero-Otin, M, Trinité, B, Twyman, RM, Capell, T, Tanuri, A, Blanco, J, Izquierdo-Useros, N, Rech, EL, Christou, P, O'Keefe, BR. Cyanovirin-N binds to select SARS-Cov-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-Cov-2. Proc Natl Acad Sci U S A 120, e2214561120, 2023. doi:10.1073/pnas.2214561120 PubMed link
2022
2021
2020
Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR. National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid isolation and identification of biologically active natural products from the NCI prefractionated library. ACS Chemical Biology 15: 1104-1114, 2020, doi: 10.1021/acschembio.0c00139. PubMed link
Kim CK, Wang D, Bokesch HR, Fuller RW, Smith E, Henrich CJ, Durrant DE, Morrison DK, Bewley CA, Gustafson KR. Swinhopeptolides A and B: Cyclic depsipeptides from the sponge Theonella swinhoei that inhibit ras/raf interaction. J Nat Prod 83: 1288-1294, 2020, doi: 10.1021/acs.jnatprod.0c00136. PubMed link
Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR, Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, Palmer KE, O'Keefe BR, Spiropoulou CF. Griffithsin inhibits Nipah virus entry and fusion and can protect Syrian golden hamsters from lethal Nipah virus challenge. J Infect Dis, 2020, doi: 10.1093/infdis/jiz630. PubMed link.
Strope JD, Peer CJ, Sissung TM, Hall OM, Huang PA, Harris EM, Gustafson KR, Henrich CJ, Sigano DM, Pauly GT, Schneider JP, Bates SE, Figg WD. Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain. Cancer Biol Ther 21: 223-230, 2019, doi: 10.1080/15384047.2019.1683324. PubMed link
Tosun F, Mihoglugil F, Beutler JA, Ozkan EE, Miski M. Neopapillarine, an unusual coumarino-alkaloid from the root extract of Neocryptodiscus papillaris with selective cytotoxicity on renal cancer cells. Molecules 25: E3040, 2020, doi: 10.3390/molecules25133040. PubMed link
Tran TD, Wilson BAP, Henrich CJ, Wendt KL, King J, Cichewicz RH, Stchigel AM, Miller AN, O'Keefe BR, Gustafson KR. Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry 173: 112278, 2020, doi: 10.1016/j.phytochem.2020.112278. PubMed link
Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, O'Keefe BR. Creating and screening natural product libraries. Nat Prod Rep, 2020, doi: 10.1039/c9np00068b. PubMed link
Wu Z, Suppo J-S, Tumova S, Strope JD, Bravo F, Moy M, Weinstein ES, Peer CJ, Figg WD, Chain WJ, Echavarren AM, Beech DJ, Beutler JA. Bridgehead modifications of englerin A reduce TRPC4 activity and intravenous toxicity but not cell growth inhibition. ACS Med Chem Lett 11: 1711-1716, 2020, doi: 10.1021/acsmedchemlett.0c00186. PubMed link
2019
Beutler JA. Natural products as a foundation for drug discovery. Curr Protocols Pharmacol 82: e67, 2019, doi: 10.1002/cpph.67. PubMed link
Grant CV, Carver CM, Hastings SD, Ramachandran K, Muniswamy M, Risinger AL, Beutler JA and Mooberry SL. Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype. Breast Cancer Res Treat 177: 345-355, 2019, doi: 10.1007/s10549-019-05324-7. Pubmed link
Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J and Khan J. 2019. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nature Comm 10:3004. doi: 10.1038/s41467-019-11046-7. PubMed link
Kang U, Caldwell DR, Cartner LK, Wang D, Kim CK, Tian X, Bokesch HR, Henrich CJ, Woldemichael GM, Schnermann MJ, Gustafson KR. Elucidation of spirodactylone, a polycyclic alkaloid from the sponge Dactylia sp., and nonenzymatic generation from the co-metabolite denigrin B. Org Lett 21: 4750-4753, 2019. doi: 10.1021/acs.orglett.9b01636. PubMed link
Matarlo JS, Krumpe LRH, Heinz WF, Oh D, Shenoy SR, Thomas CL, Goncharova EI, Lockett SJ, O'Keefe BR. The natural product butylcycloheptyl prodiginine binds pre-Mir-21, inhibits dicer-mediated processing of pre-Mir-21, and blocks cellular proliferation. Cell Chem Biol 26: 1133-1142.e4, 2019. doi: 10.1016/j.chembiol.2019.04.011. Pubmed link
Tosun F, Beutler JA, Ransom TT, Miski M. Anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin, from the root extract of Heptaptera anatolica. Molecules 24: 01153, 2019, doi: 10.3390/molecules24061153. Pubmed link
Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR. Secondary metabolites from the fungus Dictyosporium sp. and their MALT1 inhibitory activities. J Nat Prod 82:154-162, 2019. doi: 10.1021/acs.jnatprod.8b00871. Pubmed link
Tran TD, Cartner LK, Bokesch HR, Henrich CJ, Wang XW, Mahidol C, Ruchirawat S, Kittakoop P, O'Keefe BR, Gustafson KR. NMR characterization of rearranged staurosporine aglycone analogues from the marine sponge Damiria sp. Magn Reson Chem, 2019, doi: 10.1002/mrc.4932. PubMed link
Valdeira ASC, Darvishi E, Woldemichael GM, Beutler JA, Gustafson KR, Salvador JAR. Madecassic acid derivatives as potential anticancer agents: Synthesis and cytotoxic evaluation. J Nat Prod, 82: 2094-2105, 2019, doi: 10.1021/acs.jnatprod.8b00864. PubMed link
Yan P, Li G, Wang C, Wu J, Sun Z, Martin GE, Wang X, Reibarkh M, Sauri J, Gustafson KR. Characterization by empirical and computational methods of dictyospiromide, an intriguing antioxidant alkaloid from the marine alga Dictyota coriacea. Org Lett 21: 7577-7581, 2019, doi: 10.1021/acs.orglett.9b02856. PubMed link
2018
Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson JD, Peet MM, Lloyd Z, Benson M, Heneine W, O'Keefe BR, Robbiani M, Martinelli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernandez-Romero JA, Zydowsky TM. Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo. Nature Communications 9: 3881, 2018. PubMed link
Espindola LS, Dusi RG, Demarque DP, Braz-Filho R, Yan P, Bokesch HR, Gustafson KR, Beutler JA. Cytotoxic triterpenes from Salacia crassifolia and metabolite profiling of Celastraceae species. Molecules 2018; 23: 1494. PubMed link
Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD. Preclinical evaluation of discorhabdins in antiangiogenic and antitumor models. Mar Drugs 16: E241, 2018. Pubmed link.
Milanowski DJ, Oku N, Cartner LK, Bokesch HR, Williamson RT, Sauri J, Liu Y, Blinov KA, Ding Y, Li XC, Ferreira D, Walker LA, Khan S, Davies-Coleman MT, Kelley JA, McMahon JB, Martin GE, Gustafson KR. Unequivocal determination of caulamidines A and B: Application and validation of new tools in the structure elucidation tool box. Chem Sci 9: 307-314, 2018. PubMed link
Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Jr., Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Sci Rep 2018; 8: 17519. PubMed link
Rubaiy HN, Wolf D, Beutler JA, Beech DJ. Tonantzitlolone is a nanomolar potency activator of TRPC1/4/5 channels. Br J Pharmacol 175: 3361-3368, 2018. PubMed link
Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR. Harnessing natural product diversity for fluorophore discovery: Naturally occurring fluorescent hydroxyanthraquinones from the marine crinoid Pterometra venusta. J Nat Prod 81: 2750-2755, 2018. PubMed link
Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR. NCI Program for Natural Product Discovery: A publicly-accessible library of natural product fractions for high-throughput screening. ACS Chem Biol 2018, in press. PubMed link
Tian XR, Tang HF, Tian XL, Hu JJ, Huang LL, Gustafson KR. Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery. Future Med Chem 2018, in press. PubMed link
Valdeira ASC, Ritt DA, Morrison DK, McMahon JB, Gustafson KR, Salvador JAR. Synthesis and biological evaluation of new madecassic acid derivatives targeting ERK cascade signaling. Front Chem 2018; 6: 434. PubMed link
White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan IA, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble EL. India-United States dialogue on traditional medicine: Toward collaborative research and generation of an evidence base. J Glob Oncol 2018, DOI: 10.1200/JGO.17.00099: 1-10. PubMed link
Yan P, Ritt DA, Zlotkowski K, Bokesch HR, Reinhold WC, Schneekloth JS, Jr., Morrison DK, Gustafson KR. Macrophilones from the marine hydroid Macrorhynchia philippina can inhibit ERK cascade signaling. J Nat Prod 81: 1666-1672, 2018. Pubmed link
Zhao H, Masaoka T, Vardano B, Lynn AT, Aron K, Xia A, Beutler JA, Murelli RP, Tang L, Le Grice SFJ. Sensitivity of the C-terminal nuclease domain of Kaposi's sarcoma-associated herpesvirus ORF29 to different classes of active site ligands. Antimicrob Agents Chemother in press, 2017. PubMed link
2017
Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR. Identification of natural products that inhibit the catalytic function of human tyrosyl-DNA phosphodiesterase (TDP1). SLAS Discovery 22: 1093-1105, 2017. PubMed link
Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz MA, Beutler JA. Growth inhibition of colon cancer and melanoma cells by versiol derivatives from a Paraconiothyrium sp. J Nat Prod 80: 2037-2044, 2017. PubMed link
da Cunha MG, Ramos-Junior ES, Franchin M, Taira TM, Beutler JA, Franco GCN, Ikegaki M, de Alencar SM, Fukuda SY, Rosalen PL. Effects of cinnamoyloxy-mammeisin from geopropolis on osteoclast differentiation and Porphyromonas gingivalis-induced periodontitis. J Nat Prod 80: 1893-1899, 2017. PubMed link
Elliott DC, Beutler JA, Parker KA. The importance of a 4-alkyl substituent for activity in the englerin series. ACS Med Chem Lett 8: 746–750, 2017. PubMed link
Gustafson, KR, Chan, STS, Liu, Y, Assigning molecular configuration by nuclear magnetic resonance. In Modern NMR Approaches for the Structure Elucidation of Natural Products, Williams, A. J.; Martin, G. E.; Rovnyak, D., Eds. Royal Society of Chemistry: Cambridge, England; Vol. 2, pp 39-70, 2017.
Hirsch DR, Schiavone DV, Berkowitz AJ, Morrison LA, Masaoka T, Wilson JA, Lomonosova E, Zhao H, Patel BS, Datla SH, Hoft SG, Majidi SJ, Pal RK, Gallicchio E, Tang L, Tavis JE, Le Grice, SFJ, Beutler JA, Murelli, RP. Synthesis and biological assessment of 3,7-dihydroxytropolones. Org & Biomol Chem,16: 62-69, 2017. PubMed link
Irie, R, Takada, K, Ise, Y, Ohtsuka, S, Okada, S, Gustafson, KR, Matsunaga S Structure revision of poecillastrin C and the absolute configuration of the beta-hydroxyaspartic acid residue. Org Lett 19, 5395-5397, 2017. PubMed link
Jia L, Lin H, Oppenheim J, Howard OMZ., Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young M, Li W, Newman D, O'Keefe BR, Beutler J, Liu J, Hao X, Yang X, Ji, T, White JD. (2017) U.S. National Cancer Institute - China collaborative studies on Chinese medicine and cancer. J. Natl. Cancer Inst. Monographs 2017, lgx007. PubMed link
Mitchell CA, Ramessar K, O'Keefe BR. Antiviral lectins: Selective inhibitors of viral entry. Antiviral Res 142: 37-54, 2017. PubMed link
Stockdale DP, Beutler JA, Wiemer DF. Synthesis of amide isosteres of schweinfurthin-based stilbenes. Bioorg Med Chem, 25: 5483-5489, 2017. PubMed link
Wu Z, Zhao S, Fash DM, Li Z, Chain WJ, Beutler J. Englerins: A comprehensive review. J Nat Prod 80: 771-781, 2017. PubMed link
Xu YM, Brooks AD, Wijeratne EM, Henrich CJ, Tewary P, Sayers TJ, Gunatilaka AA. 17beta-Hydroxywithanolides as sensitizers of renal carcinoma cells to tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL) mediated apoptosis: Structure-activity relationships. J Med Chem 60: 3039-3051, 2017. PubMed link
Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS, Jr. Macrophilone A: Structure elucidation, total synthesis, and functional evaluation of a biologically active iminoquinone from the marine hydroid Macrorhynchia philippina. Org Lett 19: 1726-1729, 2017. PubMed link
2016
Caropreso V, Darvishi E, Turbyville TJ, Ratnayake R, Grohar PJ, McMahon JB, Woldemichael G. Englerin A inhibits EWS-FLI1 DNA binding in Ewings sarcoma cells, J Biol Chem, 291: 10058-10066, 2016. PubMed link
Chan, ST, Nani RR, Schauer EA, Martin GE, Williamson RT, Sauri J, Buevich AV, Schafer WA, Joyce LA, Goey AK, Figg WD, Ransom TT, Henrich CJ, McKee TC, Moser A, MacDonald SA, Khan S, McMahon JB, Schnermann MJ, Gustafson KR. Characterization and synthesis of eudistidine C, a bioactive marine alkaloid with an intriguing molecular scaffold. J Org Chem 81: 10631-10640, 2016. PubMed link
Chau CH, O'Keefe BR, Figg WD. The canSAR data hub for drug discovery, The Lancet Oncology, 17, 286, 2016. PubMed link
Cho N, Moon E, Kim H, Hong J, Beutler JA, Sung SH. Inhibition of nitric oxide production in BV2 microglia cells by constituents of Tetrapanax papyriferus, Molecules, 21: 459, 2016. PubMed link
Cho N, Kim HW, Ransom TT, Smith E, Beutler JA, Sung SH. Preparative isolation and purification of antiproliferative diarylheptanoids from Betula platyphylla by high speed counter-current chromatography, Molecules, 21: 700, 2016. PubMed link
da Cunha MG, Franco GCN, Franchin M, Beutler JA, de Alencar SM, Ikegaki M, Rosalen PL. Prediction of pharmacokinetic and toxicological parameters of a 4-phenyl coumarin isolated from geopropolis: In silico and in vitro approaches. Tox. Lett., 263: 6-10, 2016. PubMed link
da Cunha MG, Franchin M, de Paula-Eduardo LF, Freires IA, Beutler JA, de Alencar SM, Ikegaki M, Tabchoury CPM, Cunha TM, Rosalen PL. Anti-inflammatory and anti-biofilm properties of ent-nemorosone from Brazilian geopropolis. J.Functional Foods 26: 27-35, 2016.
Darvishi E, Woldemichael GM, Cycloheximide inhibits actin cytoskeletal dynamics by suppressing signalling via RhoA, J Cell Biochem,, 117(12): 2886-2898, 2016. PubMed link
D'erasmo M, Masaoka T, Wilson JA, Hunte, Jr. EM, Beutler JA, Le Grice SFJ, Murelli RP. Traceless solid-phase alpha-hydroxytropolone synthesis. MedChemComm 7: 1789-1792, 2016.
Fako V, Yu Z, Henrich CJ, Ransom TT, Budhu AS, Wang XW. Inhibition of wnt/beta-catenin signaling in hepatocellular carcinoma by an antipsychotic drug pimozide. Int J Biol Sci 12: 768-775, 2016. PubMed link
Fash DM, Peer CJ, Li Z, Talisman IJ, Hayavi S, Ramos JW, Figg WD, Beutler JA, Chain WJ. Synthesis of a stable and orally bioavailable englerin analogue, Bioorg.Med.Chem.Lett.,26: 2641-2644, 2016. PubMed link
Franchin M, Rosalen PL, da Cunha MG, Silva R, Colon D, Bassi G, Alencar SM, Ikegaki M, Alves-Filho J, Cunha JF, Beutler JA, Cunha T. The anti-inflammatory activity of cinnamoyloxy-mammesin, a 4-phenylcoumarin derivative isolated from geopropolis obtained from Melipona scutellaris, depends on inhibition of MAP kinases. J Nat Prod, 79: 1828-1833, 2016. PubMed link
Goey AK, Chau CH, Sissung TM, Cook KM, Venzon DJ, Castro A, Ransom TR, Henrich CJ, McKee TC, McMahon JB, Grkovic T, Cadelis MM, Copp BR, Gustafson KR, Figg WD. Screening and biological effects of marine pyrroloiminoquinone alkaloids: Potential inhibitors of the HIF-1alpha/p300 interaction, J Nat Prod, 79(5): 1267-1275, 2016. PubMed link
Henrich CJ. A microplate-based nonradioactive protein synthesis assay: Application to trail sensitization by protein synthesis inhibitors. PLoS One 11: e0165192, 2016. PubMed link
López-Suárez L, Bravo F, Riesgo L, Ransom TT, Beutler JA, and Echavarren AM. Synthesis and biological evaluation of new (-)-englerin analogues. Chem Med Chem, 11: 1003-1007, 2016. PubMed link
Masaoka T, Zhao H, Hirsch DR, D'Erasmo MP, Meck C, Vardano B, Meyers MJ, Baines J, Beutler JA, Murelli RP, Tang L, Le Grice SFJ. Characterization of the C-terminal nuclease domain of herpes simplex virus pUL15 as a target of nucleotidyltransferase inhibitors. Biochemistry, 55: 809-819, 2016. PubMed link
Murelli RP, d'Erasmo MP, Hirsch DR, Meck C, Masaoka T, Wilson JA, Zhang B, Pal RK, Galicchio E, Beutler JA, Le Grice SFJ. Synthetic alpha-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity. MedChemComm 7: 1783-1788, 2016.
Osgood CL, Maloney N, Kidd CG, Kitchen-Goosen SM, Segars LE, Gebregiorgis M, Woldemichael GM, He M, Sankar S, Lessnick SL, Kang MH, Smith MA, Turner L, Madaj ZB, Winn ME, Nunez LE, Gonzalez-Sabin J, Helman LJ, Moris F, Grohar PJ. Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor. Clin.Cancer Res., 22 (16): 4105-4118, 2016. PubMed link
Schmid T, Blees JS, Bajer MM, Wild J, Pescatori L, Crucitti LC, Scipione L, Costi R, Henrich CJ, Brüne B, Colburn NH, Di Santo R. Diaryl sulfides as novel stabilizers of tumor suppressor Pdcd4, PLoS One, 11 (2016) e0151643. PubMed link
Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stoger E, Christou P, Capell T. Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV. Plant Biotechnol J, 14: 1427-1437, 2016. PubMed link
Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T. Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1 infection in vitro, Plant Cell Rep, 35: 1309-1319, 2016. PubMed link
Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, and O'Keefe BR. Discovery and characterization of a biologically active non-ATP-competitive p38 MAP kinase Inhibitor. J.Biomol.Screen. 21: 277-289, 2015. PubMed link
Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G. A designed "nested" dimer of cyanovirin-N increases antiviral activity, Viruses, 8 (2016). PubMed link
Yeo D, Huynh N, Beutler JA, Baldwin GS, He H, Nikfarjam M. Glaucarubinone combined with gemcitabine improves pancreatic cancer survival in a immunocompetent orthotopic murine model. J.Invest.Surg. 30: 1-7, 2016. PubMed link
Yuan W, Cheng S, Fu W, Zhao M, Li X, Cai Y, Dong J, Huang K, Gustafson KR, Yan P. Structurally diverse metabolites from the soft coral Sinularia verruca collected in the South China Sea. J.Nat.Prod.,79: 1124-1131, 2016. PubMed link
Zhao M, Cheng S, Yuan W, Xi Y, Li X, Dong J, Huang K, Gustafson KR, P. Yan P. Cembranoids from a Chinese collection of the soft coral Lobophytum crassum, Mar Drugs, 14 (2016). PubMed link
2015
Beutler JA, Development of englerins for cancer therapy, Czech Chem.Soc.Symp.Ser., 13: 174-176, 2015.
Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, and Gustafson KR. Structural elucidation and synthesis of eudistidine A: An unusual polycyclic marine alkaloid that blocks interaction of the protein binding domains of p300 and HIF-1alpha. J.Am.Chem.Soc. 137 (16):5569-5575, 2015. PubMed link
Chatterjee A, Ratner DM, Ryan CM, Johnson PJ, O'Keefe BR, Secor WE, Anderson DJ, Robbins PW, and Samuelson J. Anti-retroviral lectins have modest effects on adherence of Trichomonas vaginalis to epithelial cells in vitro and on recovery of Tritrichomonas foetus in a mouse vaginal model. PLoS One 10 (8):e0135340, 2015. PubMed link
da Cunha MG, de Alencar SM, Ikegaki M, Rosalen PL, Ransom TT, and Beutler JA. Major constituents of Melipona scutellaris geopropolis and their antiproliferative activity. Planta Med. 82: 190-204, 2015.PubMed link
Forcina GC, Castro A, Bokesch HR, Spakowicz DJ, Legaspi ME, Kucera K, Villota S, Narvaez-Trujillo A, McMahon JB, Gustafson KR, Strobel SA. Stelliosphaerols A and B, sesquiterpene-polyol conjugates from an Ecuadorian fungal endophyte. J.Nat.Prod., 78: 3005-3010, 2015. PubMed link
Henrich CJ, Brooks AD, Erickson KL, Thomas CL, Bokesch HR, Tewary P, Thompson CR, Pompei RJ, Gustafson KR, McMahon JB, and Sayers TJ. Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death.Dis. 6:e1666, 2015. PubMed link
Henrich CJ, Cartner LK, Wilson JA, Fuller RW, Rizzo AE, Reilly KM, McMahon JB, and Gustafson KR. Deguelins, natural product modulators of NF1-defective astrocytoma cell growth Identified by high-throughput screening of partially purified natural product extracts. J.Nat.Prod., 78: 2776-2781, 2015. PubMed link
Jakób, M, Lubkowski, J, O'Keefe, BR, and Wlodawer, A. Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL). Acta Crystallograf., 71: 1429-1436, 2015. PubMed link
Jayatunga MKP, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, and Hamilton AD. Inhibition of the HIF1alpha-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). Eur.J.Med.Chem. 94:509-516, 2015. PubMed link
Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, and Fernandez-Romero JA. Griffithsin and carrageenan combination to target HSV-2 and HPV. Antimicrob.Agents Chemother., 59: 7290-7298, 2015. PubMed link
Ma J, Pawar RS, Grundel E, Mazzola EP, Ridge CD, Masaoka T, Le Grice SFJ, Wilson JA, Beutler JA, and Krynitsky AJ. Sesquiterpenoid tropolone glycosides from Liriosma ovata. J.Nat.Prod. 78 (2):315-319, 2015. PubMed link
Moulaei T, Alexandre KB, Shenoy SR, Meyerson J, Krumpe LR, Constantine B, Wilson J, Buckheit R, McMahon JB, Subramaniam S, Wlodawer A, and O' Keefe BR. Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Retrovirology 12 (1):6, 2015. PubMed link
O'Keefe, BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, Buckheit KW, da Cunha NB, Araujo AC, Lacorte CC, Madeira L, McMahon JB, and Rech EL. Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV. Plant Biotechnol.J. (7):884-892, 2015. PubMed link
Patridge EV, Darnell A, Kucera K, Phillips GM, Bokesch HR, Gustafson KR, Spakowicz DJ, Zhou L, Hungerford WM, Plummer M, Hoyer D, Narvaez-Trujillo A, Phillips AJ, Strobel SA, Pyrrolocin A, a 3-decalinoyltetramic acid with selective biological activity, isolated from Amazonian cultures of the novel endophyte Diaporthales sp. E6927E. Nat.Prod.Comm. 10: 1649-1654, 2015. PubMed link
Qin T, Beutler JA, and Porco, Jr JA. Synthesis of dimeric tetrahydroxanthones with varied linkages: Investigation of shapeshifting properties. J.Am.Chem.Soc. 137(48): 15225-15233, 2015. PubMed link
Shin HJ, Rashid MA, Cartner LK, Bokesch HR, Wilson JA, McMahon JB, and Gustafson KR. Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp. Tetrahedron Lett. 56 (28):4215-4219, 2015. PubMed link
Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutler JA, Linehan WM, and Neckers L. Tonantzitlolone cytotoxicity toward renal cancer cells is PKCtheta- and HSF1-dependent. Oncotarget, 6 (30): 29963-29974, 2015. PubMed link
Zhao H, Lin Z, Lynn AY, Vardano B, Beutler JA, Murelli RP, Le Grice SFJ, and Tang L. Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism. Nucl.Acids Res.43: 11003-11016, 2015. PubMed link
2014
Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, and Brune B. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem.Pharmacol. 88 (3): 313-321, 2014. PubMed link
Beutler JA, Cragg GM, Iwu M, Newman DJ, and Okunji C. Anticancer Potential of African Plants. The Experience of the United States National Cancer Institute and National Institutes of Health. Chapter 10 In: Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics, edited by A. Gurib-Fakim,Wiley-Blackwell, p.133-149, 2014.
Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, and Beutler JA. Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells. Phytochem.Lett. 7 (1):42-45, 2014. PubMed link
Dull AB, George AA, Goncharova EI, Evans JR, Wamiru A, Cartner LK, Hager GL, and McMahon JB. Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor a chimera and exhibit agonist or antagonist activity in vitro. J.Biomol.Screen. 19 (2):242-252, 2014. PubMed link
Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger Jr. GG, McMahon JB, Huggins J, and O'Keefe BR. The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus. Antiviral Res. 112: 1-7, 2014. PubMed link
Grkovic T, Blees JS, Bayer MM, Colburn MM, Thomas CL, Henrich CJ, Peach ML, McMahon JB, Schmid T, and Gustafson KR. Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4. Mar.Drugs 12 (8):4593-4601, 2014. PubMed link
Hartung AM, Beutler JA, Navarro HA, Wiemer DF, and Neighbors JD. Stilbenes as kappa-selective non-nitrogenous opioid receptor antagonists. J.Nat.Prod. 77 (2): 311-319, 2014. PubMed link
Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur YH, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, and Reed JC. Ultra-high-throughput screening of natural product extracts to identify proapoptotic inhibitors of bcl-2 family proteins. J.Biomol.Screen. 19 (8):1201-1211, 2014. PubMed link
Jensen SM, Ruscetti FW, Rein A, Bertolette DC, Saucedo CJ, O'Keefe BR, and Jones KS. Differential inhibitory effects of cyanovirin-N, griffithsin and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses. J.Virol. 88 (4):2327-2332, 2014. PubMed link
Kodet JG, Beutler JA, and Wiemer DF. Synthesis and structure activity relationships of schweinfurthin indoles. Bioorg.Med.Chem. 22 (8): 2542-2552, 2014. PubMed link
McKee TC, Van Wyk AW, and Whitson EL. Natural Product Screening. In: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, edited by Figg DWand, and McLeod HL, Totoawa, NJ: Humana Press, 2014, p. 39-67.
Sunassee S, Ransom TT, Henrich CJ, Beutler JA, Covell DG, McMahon JB, and Gustafson KR. Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells. J.Nat.Prod. 77: 2475-2480, 2014. PubMed link
Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SFJ, O'Keefe BR, and Schneekloth, Jr JS. Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays. J.Am.Chem.Soc., 136: 8402-8410, 2014. PubMed link
Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes CA, Baldwin GS, Nikfarjam M, and He H. Glaucarubinone and gemcitibine synergistically reduce pancreatic cancer growth via inhibition of p21-activated kinases. Cancer Lett. 346 (2): 264-272, 2014. PubMed link
2013
Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, McMahon JB, O'Keefe BR, Chikwamba R, and Morris L. Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN. Virology 446 (1-2):66-76, 2013. PubMed link
Beutler JA. Natural Products as Tools for Discovering New Cancer Targets. In: Natural Products and Cancer Drug Discovery, edited by Koehn FE, New York: Humana Press, 2013, p. 213-237.
Devkota KP, Wilson J, Henrich CJ, McMahon JB, Reilly KM, and Beutler JA. Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth. J.Nat.Prod. 76 (1):59-63, 2013. PubMed link
Devkota KP, Covell DG, Ransom TT, McMahon JB, and Beutler JA. Growth inhibition of human colon carcinoma cells by sesquiterpenoids and tetralones of Zygogynum calothyrsum. J.Nat.Prod. 76 (4):710-714, 2013. PubMed link
Dossou KS, Devkota KP, Kavanogh P, Egan J, Beutler JA, and Moaddel R. Development and preliminary validation of a plate-based CB1/CB2 receptor functional assay. Anal.Biochem. 437 (2):137-143, 2013. PubMed link
Dossou KKS, Devkota KP, Morton C, Egan JM, Beutler JA, and Moaddel R. Identification of CB1/CB2 ligands from Zanthoxylum bungeanum. J.Nat.Prod. 76 (11):2060-2064, 2013. PubMed link
Henrich CJ, Budhu A, Yu Z, Evans JR, Goncharova EI, Ransom TT, Wang XW, and McMahon JB. High-throughput screening for identification of inhibitors of EpCAM-dependent growth of hepatocellular carcinoma cells. Chem.Biol.Drug Des 82 (2):131-139, 2013. PubMed link
Henrich CJ and Beutler JA. Matching the power of high throughput screening to the chemical diversity of natural products. Nat.Prod.Repts. 30(10):1284-1298, 2013. PubMed link
Kanduluru AK, Banerjee P, Beutler JA, and Fuchs PL. A convergent total synthesis of the potent cephalostatin/ritterazine hybrid 25-epi ritterostatin GN1N. J.Org.Chem. 78 (18):9085-9092, 2013. PubMed link
Masaoka T, Chung S, Carboni P, Wilson JA, Beutler JA, Tocco G, and Le Grice SFJ. Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J.Med.Chem. 56:5436-5445, 2013. PubMed link
Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee JM, Trepel JB, Beutler JA, Linehan WM, and Neckers LM. Englerin A stimulates PKC theta to inhibit insulin signaling while simultaneously activating HSF1: A case of pharmacologically induced synthetic lethality. Cancer Cell 23 (2):228-237, 2013. PubMed link CCR news
Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, and O'Keefe BR. Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus. PLoS One 8 (5):e64449, 2013. PubMed link
Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, and Porco, Jr JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a simplified tetrahydroxanthone analogue. J.Org.Chem. 78 (15):7617-7626, 2013. PubMed link
2012
Beutler JA, Cragg GM, and Newman DJ. The National Cancer Institute and Natural Product Based Drug Discovery in Africa. In: Drug Discovery in Africa, edited by Chibale K, Davies-Coleman MT, and Masimirembwa C,Springer, 2012, p. 29-51.
Hatanaka T, Ohzono S, Park M, Sakamoto K, Tsukamoto S, Sugita R, Ishitobi H, Mori T, Ito O, Sorajo K, Sugimura K, Ham S, and Ito Y. Human IgA-binding peptides selected from random peptide libraries: Affinity maturation and application in IgA purification. J.Biol.Chem. 287 (51):43126-43136, 2012. PubMed link
2011
2010
2009
2008
2007
D.F. Smee, M.K. Wandersee, M.B. Checketts, B.R. O'Keefe, C. Saucedo, M.R. Boyd, V.P. Mishin, L.V. Gubareva. Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor. Antivir Chem Chemother.18(6):317-27, 2007. PubMed link
2006
2005
2004
2003
2002
Charan RD, McKee TC, Boyd MR. Thorectandrols C, D, and E, new sesterterpenes from the marine sponge Thorectandra sp. J Nat Prod 65: 492-495, 2002, doi: 10.1021/np010439k. PubMed link
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