2020 NCI Staff Scientists and Staff Clinicians Scientific Workshop

Following the unexpected cancellation of the 16th Annual CCR and DCEG Staff Scientist and Staff Clinician retreat due to COVID19, we are pleased to announce a two-day scientific workshop in lieu of our initially scheduled retreat.

The workshop will feature 10 min presentations from selected abstracts originally submitted to the 2020 CCR and DCEG SS/SC retreat.

The NCI SS/SC Workshop will be held on May 20 and 27, 2020.

We are looking forward to seeing you at this event!
Sincerely,
The 2020 NCI SS/SC Retreat Planning Committee

DAY 1

May 20, 1 PM-3 PM

https://cbiit.webex.com/cbiit/j.php?MTID=m39f334cd4591b10900d17aaef19af970

Meeting number (access code): 477 937 109
Meeting password: G6nKxwYm*85

DAY 2

May 27, 1 PM-3 PM

https://cbiit.webex.com/cbiit/j.php?MTID=m8327ea7462cac76fd3a530ab3c0ae2d8

Meeting number (access code): 471 564 585
Meeting password: gGTmJQv?569

Please see AGENDA below

Please address your questions and comments to:

NCI SS/SC Retreat Planning Committee Co-Chairs

Nicolas Çuburu (cuburun@mail.nih.gov)
Duane Hamilton (duane.hamilton@nih.gov)

AGENDA

Day 1, May 20, 1 PM - 3 PM

1:05-1:15 pm Scott Walsh: Structural and Functional Studies of Two Newly Developed Monoclonal Antibodies Targeting the Interleukin-7 Receptor for Leukemia Treatment

1:15-1:25 pm Chi-Ping Day: Cross-species Validation of Single Cell Sequencing Results Revealed Subpopulations with Different Functions in Mouse Melanoma

1:25-1:35 pm Feng Zhu: Candida albicans infection mediates gastrointestinal track malignancy independently of Il17a in an APECED mouse model

1:35-1:45 pm Nicolas Cuburu: Harnessing pre-existing cytomegalovirus T cell immunity for intratumoral cancer immunotherapy

1:45-2:00 pm Questions

2:05-2:15 pm Sukhbir Kaur: CD47 interactions with the exportin-1 pathway in T cells regulate nuclear export and selective targeting of microRNAs to extracellular vesicles

2:15-2:25 pm Jacqueline Salotti: 3'UTR-Mediated Perinuclear mRNA Decay (PMD) Inhibits C/EBPÎ² Activity and Suppresses Senescence in Tumor Cells

2:25-2:35 pm Yoshimi Greer: Mitochondrial matrix protease ClpP agonists inhibit cell growth and cancer stem cell function in breast cancer cells

2:35-2:45 pm Balamurugan Kuppusamy: The COX-2/PGE2/GSK3b pathway promotes tumor cell adhesion by E-cadherin and is a candidate target for inflammatory breast cancer

2:45-3:00 pm Questions

Day 2, May 27, 1 PM - 3 PM

1:05-1:15 pm Julian Candia: The Genomic Landscape of Mongolian Hepatocellular Carcinoma

1:15-1:25 pm Margaret Gatti-Mays: From Bench to Bedside: Preclinical antitumor and immune effects of BN-Brachyury, Entinostat, Ado-trastuzumab emtansine (T-DM1) and Bintrafusp alfa (M7824) and the Resulting Phase 1b Clinical Trial for Advanced Stage Breast Cancer

1:25-1:35 pm Jun Wei: Immuno-Transcriptomic Profiling Identifies Actionable Alterations in Pediatric Solid Malignancies

1:35-1:45 pm Brunilde Gril: A HER2 Antibody Drug Conjugate Controls Growth of Breast Cancer Brain Metastases in Hematogenous Xenograft Models

1:45-2:00 pm Questions

2:05-2:15 pm Vladimir Majerciak: Use of a Novel CRISPR-CAS9 Technology to Knock Out Viral Genes in the Cells with Hundreds Copies of the Viral Genomes

2:15-2:25 pm Will Heinz: Modeling Inflammation Induced Immuno-suppression in Tumors Using Mutiplexed Immunofluorescence Microscopy and a Novel Live Cell Hypoxia Chamber

2:25-2:35 pm Taylor Updegrove: Resurrection of Ancestral GTPase Activity in an Extant Bacterial ATPase Reveals a Nucleotide Base Requirement for Function

2:35-2:45 pm Cristina Bergamaschi: Heterodimeric IL-15 Delays Tumor Growth and Promotes Intratumoral CTL and Dendritic Cell Accumulation by a Cytokine Network Involving XCL1, IFN- gamma, CXCL9 and CXCL10

2:45-3:00 pm Questions

3:00-3:15 pm AWARD PRESENTATION
CLOSING REMARKS by Douglas Lowy, M.D., Principal Deputy Director, NCI

2020 NCI Staff Scientists and Staff Clinicians Scientific Workshop

Following the unexpected cancellation of the 16th Annual CCR and DCEG Staff Scientist and Staff Clinician retreat due to COVID19, we are pleased to announce a two-day scientific workshop in lieu of our initially scheduled retreat.

The workshop will feature 10 min presentations from selected abstracts originally submitted to the 2020 CCR and DCEG SS/SC retreat.

The NCI SS/SC Workshop will be held on May 20 and 27, 2020.

We are looking forward to seeing you at this event!Sincerely,The 2020 NCI SS/SC Retreat Planning Committee

DAY 1

May 20, 1 PM-3 PM

DAY 2

May 27, 1 PM-3 PM

Please see AGENDA below

Please address your questions and comments to:

NCI SS/SC Retreat Planning Committee Co-ChairsNicolas Çuburu (cuburun@mail.nih.gov)Duane Hamilton (duane.hamilton@nih.gov)

AGENDA

Day 1, May 20, 1 PM - 3 PM

1:05-1:15 pm Scott Walsh: Structural and Functional Studies of Two Newly Developed Monoclonal Antibodies Targeting the Interleukin-7 Receptor for Leukemia Treatment

1:15-1:25 pm Chi-Ping Day: Cross-species Validation of Single Cell Sequencing Results Revealed Subpopulations with Different Functions in Mouse Melanoma

1:25-1:35 pm Feng Zhu: Candida albicans infection mediates gastrointestinal track malignancy independently of Il17a in an APECED mouse model

1:35-1:45 pm Nicolas Cuburu: Harnessing pre-existing cytomegalovirus T cell immunity for intratumoral cancer immunotherapy

1:45-2:00 pm Questions

2:05-2:15 pm Sukhbir Kaur: CD47 interactions with the exportin-1 pathway in T cells regulate nuclear export and selective targeting of microRNAs to extracellular vesicles

2:15-2:25 pm Jacqueline Salotti: 3'UTR-Mediated Perinuclear mRNA Decay (PMD) Inhibits C/EBPÎ² Activity and Suppresses Senescence in Tumor Cells

2:25-2:35 pm Yoshimi Greer: Mitochondrial matrix protease ClpP agonists inhibit cell growth and cancer stem cell function in breast cancer cells

2:35-2:45 pm Balamurugan Kuppusamy: The COX-2/PGE2/GSK3b pathway promotes tumor cell adhesion by E-cadherin and is a candidate target for inflammatory breast cancer

2:45-3:00 pm Questions

1:05-1:15 pm Julian Candia: The Genomic Landscape of Mongolian Hepatocellular Carcinoma

1:15-1:25 pm Margaret Gatti-Mays: From Bench to Bedside: Preclinical antitumor and immune effects of BN-Brachyury, Entinostat, Ado-trastuzumab emtansine (T-DM1) and Bintrafusp alfa (M7824) and the Resulting Phase 1b Clinical Trial for Advanced Stage Breast Cancer

1:25-1:35 pm Jun Wei: Immuno-Transcriptomic Profiling Identifies Actionable Alterations in Pediatric Solid Malignancies

1:35-1:45 pm Brunilde Gril: A HER2 Antibody Drug Conjugate Controls Growth of Breast Cancer Brain Metastases in Hematogenous Xenograft Models

1:45-2:00 pm Questions

2:05-2:15 pm Vladimir Majerciak: Use of a Novel CRISPR-CAS9 Technology to Knock Out Viral Genes in the Cells with Hundreds Copies of the Viral Genomes

2:15-2:25 pm Will Heinz: Modeling Inflammation Induced Immuno-suppression in Tumors Using Mutiplexed Immunofluorescence Microscopy and a Novel Live Cell Hypoxia Chamber

2:25-2:35 pm Taylor Updegrove: Resurrection of Ancestral GTPase Activity in an Extant Bacterial ATPase Reveals a Nucleotide Base Requirement for Function

2:35-2:45 pm Cristina Bergamaschi: Heterodimeric IL-15 Delays Tumor Growth and Promotes Intratumoral CTL and Dendritic Cell Accumulation by a Cytokine Network Involving XCL1, IFN- gamma, CXCL9 and CXCL10

2:45-3:00 pm Questions

3:00-3:15 pm AWARD PRESENTATION CLOSING REMARKS by Douglas Lowy, M.D., Principal Deputy Director, NCI

We are looking forward to seeing you at this event!
Sincerely,
The 2020 NCI SS/SC Retreat Planning Committee

NCI SS/SC Retreat Planning Committee Co-Chairs

Nicolas Çuburu (cuburun@mail.nih.gov)
Duane Hamilton (duane.hamilton@nih.gov)

3:00-3:15 pm AWARD PRESENTATION
CLOSING REMARKS by Douglas Lowy, M.D., Principal Deputy Director, NCI