Selected Publications:

  1. Kuznetsov, S.G., Liu, P. and Sharan, S.K. (2008) Mouse ES-cell-based functional assay to evaluate mutations in BRCA2. Nature Medicine 8:875-881
  2. Li, L., Biswas, K., Habib, L., Kuznetsov, S.G., Hamel, N., Kirchhoff, T., Wong, N., Armel, S., Tavtigian, S.V., Chong, G., Narod, S.A., Claes, K., Offit, K., Robson, M.E., Sharan, S.K. and Foulkes, W.D. (2009) Functional redundancy of exon 12 of BRCA2 revealed by a comprehensive analysis of the c.6853A>G (p.I2285V) variant. Human Mutation 30:1543-1450.
  3. Chang, S., Biswas, K., Martin, B.K., Stauffer, S. and Sharan, S.K. (2009) Functional analysis of BRCA1 variants using a mouse ES cell based assay and humanized mouse models. Journal of Clinical Investigation 119:3160-3171.
  4. Kuznetsov, S.G., Chang, S. and Sharan, S.K. (2010) Functional Analysis Of Human BRCA2 Variants Using A Mouse Embryonic Stem Cell-Based Assay. Methods in Molecular Biology 653:259-80.
  5. Biswas, K., Das, R., Alter, B.P., Kuznetsov, S.G., Stauffer, S., North, S.L., Brody, L. C., Meyer, S., Byrd R.A. and Sharan, S.K. (2011) A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay. Blood 118:2430-42.
  6. Chang, S., Wang, R., Agaki, K., Kim, K., Martin, B.K., Cavallone, L., Haines, D., Basik, M., Mai, P., Poggi, E., Issacs, C., Looi, L., Mun, K., Greene, M., Byers, S., Teo, S., Deng, C.-X., and Sharan, S.K. (2011) Tumor Suppressor BRCA1 epigenetically controls oncogenic miRNA-155. Nature Medicine 17:1275-1283.
  7. Biswas K, Das R, Eggington JM, Qiao H, North SL, Stauffer S, Burkett SS, Martin BK, Southon E, Sizemore SC, Pruss D, Bowles KR, Roa BB, Hunter N, Tessarollo L, Wenstrup RJ, Byrd RA, and Sharan SK. (2012) Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Hum Mol Genet. 2012 21:3993-4006.
  8. Bakker, J.L.*, Thirthagiri, E.*, van Mil, S.E., Adank, M.A. Ikeda, H., Henk M.W. Verheul, H.M.W., Hanne Meijers-Heijboer, H., Johan P de Winter, J.P., Sharan, S.K., and Waisfisz, Q. (2014) Novel pathogenic mutation in splice donor site of non-coding exon 1 of BRCA2 in a Fanconi Anemia patient has possible implications for BRCA1/2 mutation screening. Human Mutation 35:442-426.
  9. Hendriks, G., Morolli, B., Calléja, F.M., Plomp, A., Mesman, R.L., Meijers, M., Sharan, S.K., Vreeswijk, M.P. and Vrieling, H. (2014) An efficient pipeline for the generation and functional analysis of Human BRCA2 variants of uncertain significance. Human Mutation 35(11):1382-1391.