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2024
2023
Borhani, SG, Levine, MZ, Krumpe, L,H, Wilson, J, Henrich, CJ, = O'Keefe, BR, Lo, DC, Sittampalam, GS, Godfrey, AG, Lunsford, RD, Mangalampa= lli, V, Tao, D, LeClair, CA, Thole, AP, Frey, D, Swartz, J, Rao, G, An appr= oach to rapid distributed manufacturing of broad spectrum anti-viral griffi= thsin using cell-free systems to mitigate pandemics. N Biotechnol 76, 13-22= , 2023. doi:10.1016/j.nbt.2023.04.003 PubMed link= span>
Di, X, Hardardottir,I , Freysdottir, J, Wang, D, Gustafson, KR= , Omarsdottir, S, Molinski, TF., Geobarrettin D, a rare herbipoline-contain= ing 6-bromoindole alkaloid from Geodia barretti. Molecules 28, 293= 7, 2023. doi: 10.3390/molecules28072937 PubMed lin= k
Evans, JR, Akee, RK, Chanana, S, McConachie, GD, Thornburg, CC= , Grkovic, T, O'Keefe, BR. National Cancer Institute (NCI) Program for Natu= ral Product Discovery: Exploring NCI-60 screening data of natural product s= amples with artificial neural networks. ACS Omega 8, 9250-9256, 2023. doi:1= 0.1021/acsomega.2c07416 PubMed link
Mu=C3=B1oz-Basagoiti, J, Monteiro, FLL, Krumpe, LRH, Armario-N= ajera, V, Shenoy, SR, Perez-Zsolt, D, Westgarth, HJ, Villorbina, G, Bomfim,= LM, R=C3=A4ich-Regu=C3=A9, D, Nogueras, L, Henrich, CJ, Gallemi, M, Moreir= a, FRR, Torres, P, Wilson, J, D'Arc, M, Marfil, S, Herlinger, AL, Pradenas,= E, Higa, LM, Portero-Otin, M, Trinit=C3=A9, B, Twyman, RM, Capell, T, Tanu= ri, A, Blanco, J, Izquierdo-Useros, N, Rech, EL, Christou, P, O'Keefe, BR. = Cyanovirin-N binds to select SARS-Cov-2 spike oligosaccharides outside of t= he receptor binding domain and blocks infection by SARS-Cov-2. Proc Natl Ac= ad Sci U S A 120, e2214561120, 2023. doi:10.1073/pnas.2214561120 PubMed link
2022
2021
2020
Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Eva= ns JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR.= National Cancer Institute (NCI) Program for Natural Products Discovery: Ra= pid isolation and identification of biologically active natural products fr= om the NCI prefractionated library. ACS Chemical Biology 15: 1104-1114, 202= 0, doi: 10.1021/acschembio.0c00139. PubMed link<= /p>
Kim CK, Wang D, Bokesch HR, Fuller RW, Smith E, Henrich CJ, Durrant = DE, Morrison DK, Bewley CA, Gustafson KR. Swinhopeptolides A and B: Cyclic = depsipeptides from the sponge Theonella swinhoei that inhibit ras/= raf interaction. J Nat Prod 83: 1288-1294, 2020, doi: 10.1021/acs.jnatprod.= 0c00136. PubMed link
Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR= , Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, = Palmer KE, O'Keefe BR, Spiropoulou CF. Griffithsin inhibits Nipah virus ent= ry and fusion and can protect Syrian golden hamsters from lethal Nipah viru= s challenge. J Infect Dis, 2020, doi: 10.1093/infdis/jiz630. PubMed link.
Strope JD, Peer CJ, Sissung TM, Hall OM, Huang PA, Harris EM, Gustaf= son KR, Henrich CJ, Sigano DM, Pauly GT, Schneider JP, Bates SE, Figg WD. B= otryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mou= se brain. Cancer Biol Ther 21: 223-230, 2019, doi: 10.1080/15384047.2019.16= 83324. PubMed link
Tosun F, Mihoglugil F, Beutler JA, Ozkan EE, Miski M. Neopapillarine= , an unusual coumarino-alkaloid from the root extract of Neocryptodiscu= s papillaris with selective cytotoxicity on renal cancer cells. Molecu= les 25: E3040, 2020, doi: 10.3390/molecules25133040. Pu= bMed link
Tran TD, Wilson BAP, Henrich CJ, Wendt KL, King J, Cichewicz RH, Stc= higel AM, Miller AN, O'Keefe BR, Gustafson KR. Structure elucidation and ab= solute configuration of metabolites from the soil-derived fungus Dictyo= sporium digitatum using spectroscopic and computational methods. Phyto= chemistry 173: 112278, 2020, doi: 10.1016/j.phytochem.2020.112278. PubMed link
Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, O'Keefe BR. Creatin= g and screening natural product libraries. Nat Prod Rep, 2020, doi: 10.1039= /c9np00068b. PubMed link
Wu Z, Suppo J-S, Tumova S, Strope JD, Bravo F, Moy M, Weinstein ES, = Peer CJ, Figg WD, Chain WJ, Echavarren AM, Beech DJ, Beutler JA. Bridgehead= modifications of englerin A reduce TRPC4 activity and intravenous toxicity= but not cell growth inhibition. ACS Med Chem Lett 11: 1711-1716, 2020, doi= : 10.1021/acsmedchemlett.0c00186. PubMed link
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2019
Beutler JA. Natural products as a foundation for drug discovery. Cur= r Protocols Pharmacol 82: e67, 2019, doi: 10.1002/cpph.67. PubMed link
Grant CV, Carver CM, Hastings SD, Ramachandran K, Muniswamy M, Risin= ger AL, Beutler JA and Mooberry SL. Triple-negative breast cancer cell line= sensitivity to englerin A identifies a new, targetable subtype. Breast Can= cer Res Treat 177: 345-355, 2019, d= oi: 10.1007/s10549-019-05324-7. Pubmed l= ink
Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cle= veland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J and = Khan J. 2019. Chemical genomics reveals histone deacetylases are required f= or core regulatory transcription. Nature Comm 10:3004. doi: 10.1038/s41467-019-11046-7. PubMed link
Kang U, Caldwell DR, Cartner LK, Wang D, Kim CK, Tian X, Bokesch HR,= Henrich CJ, Woldemichael GM, Schnermann MJ, Gustafson KR. Elucidation of s= pirodactylone, a polycyclic alkaloid from the sponge Dactylia sp.,= and nonenzymatic generation from the co-metabolite denigrin B. Org Lett 21= : 4750-4753, 2019. doi: 10.1021/acs= .orglett.9b01636. PubMed link
Matarlo JS, Krumpe LRH, Heinz WF, Oh D, Shenoy SR, Thomas CL, Goncha= rova EI, Lockett SJ, O'Keefe BR. The natural product butylcycloheptyl prodi= ginine binds pre-Mir-21, inhibits dicer-mediated processing of pre-Mir-21, = and blocks cellular proliferation. Cell Chem Biol 26: 1133-1142.e4, 2019. doi: 10.1016/j.chembiol.2019.04.011. Pubmed link
Tosun F, Beutler JA, Ransom TT, Miski M. Anatolicin, a highly potent= and selective cytotoxic sesquiterpene coumarin, from the root extract of&n= bsp;Heptaptera anatolica. Molecules 24: 01153, 2019= , doi: 10.3390/molecules24061153.= Pubmed link
Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, Ki= ng J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson= KR. Secondary metabolites from the fungus Dictyosporium = ;sp. and their MALT1 inhibitory activities. J Nat Prod 82:154-162, 2019. doi: 10.1021/acs.jnatprod.8b00871. Pubmed link
Tran TD, Cartner LK, Bokesch HR, Henrich CJ, Wang XW, Mahidol C, Ruc= hirawat S, Kittakoop P, O'Keefe BR, Gustafson KR. NMR characterization of r= earranged staurosporine aglycone analogues from the marine sponge Damiria s= p. Magn Reson Chem, 2019, doi: 10.1002/mrc.4932. Pub= Med link
Valdeira ASC, Darvishi E, Woldemichael GM, Beutler JA, Gustafson KR,= Salvador JAR. Madecassic acid derivatives as potential anticancer agents: = Synthesis and cytotoxic evaluation. J Nat Prod, 82: 2094-2105, 2019, doi: 1= 0.1021/acs.jnatprod.8b00864. PubMed link
Yan P, Li G, Wang C, Wu J, Sun Z, Martin GE, Wang X, Reibarkh M, Sau= ri J, Gustafson KR. Characterization by empirical and computational methods= of dictyospiromide, an intriguing antioxidant alkaloid from the marine alg= a Dictyota coriacea. Org Lett 21: 7577-7581, 2019, doi: 10.1021/ac= s.orglett.9b02856. PubMed link
2018
Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, La= i M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson= JD, Peet MM, Lloyd Z, Benson M, Heneine W, O'Keefe BR, Robbiani M, Martine= lli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernandez-Romero JA= , Zydowsky TM. Griffithsin carrageenan fast dissolving inserts prevent SHIV= HSV-2 and HPV infections in vivo. Nature Communications 9: 3881, 2018. PubMed link
Espindola LS, Dusi RG, Demarque DP, Braz-Filho R, Yan P, Bokesch HR,= Gustafson KR, Beutler JA. Cytotoxic triterpenes from Salacia crassifol= ia and metabolite profiling of Celastraceae species. Molecules 2018; 2= 3: 1494. PubMed link
Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofi= eld CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD. Preclinical ev= aluation of discorhabdins in antiangiogenic and antitumor models. Mar Drugs= 16: E241, 2018. Pubmed link.
Milanowski DJ, Oku N, Cartner LK, Bokesch HR, Williamson RT, Sauri J= , Liu Y, Blinov KA, Ding Y, Li XC, Ferreira D, Walker LA, Khan S, Davies-Co= leman MT, Kelley JA, McMahon JB, Martin GE, Gustafson KR. Unequivocal deter= mination of caulamidines A and B: Application and validation of new tools i= n the structure elucidation tool box. Chem Sci 9: 307-314, 2018. PubMed link
Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Jr., Henrich CJ.= Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocag= lamide and analogs. Sci Rep 2018; 8: 17519. PubMed l= ink
Rubaiy HN, Wolf D, Beutler JA, Beech DJ. Tonantzitlolone is a nanomo= lar potency activator of TRPC1/4/5 channels. Br J Pharmacol 175: 3361= -3368, 2018. PubMed link
Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ,= Gustafson KR. Harnessing natural product diversity for fluorophore discove= ry: Naturally occurring fluorescent hydroxyanthraquinones from the marine c= rinoid Pterometra venusta. J Nat Prod 81: 2750-2755, 2018. PubMed link
Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harri= s MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider = JP, Grkovic T, O'Keefe BR. NCI Program for Natural Product Discovery: A pub= licly-accessible library of natural product fractions for high-throughput s= creening. ACS Chem Biol 2018, in press. PubMed link<= /a>
Tian XR, Tang HF, Tian XL, Hu JJ, Huang LL, Gustafson KR. Review of = bioactive secondary metabolites from marine bryozoans in the progress of ne= w drugs discovery. Future Med Chem 2018, in press. P= ubMed link
Valdeira ASC, Ritt DA, Morrison DK, McMahon JB, Gustafson KR, Salvad= or JAR. Synthesis and biological evaluation of new madecassic acid derivati= ves targeting ERK cascade signaling. Front Chem 2018; 6: 434. PubMed link
White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan I= A, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble= EL. India-United States dialogue on traditional medicine: Toward collabora= tive research and generation of an evidence base. J Glob Oncol 2018, DOI: 1= 0.1200/JGO.17.00099: 1-10. PubMed link
Yan P, Ritt DA, Zlotkowski K, Bokesch HR, Reinhold WC, Schneekloth J= S, Jr., Morrison DK, Gustafson KR. Macrophilones from the marine hydroid Ma= crorhynchia philippina can inhibit ERK cascade signaling. J Nat Prod 81: 16= 66-1672, 2018. Pubmed link
Zhao H, Masaoka T, Vardano B, Lynn AT, Aron K, Xia A, Beutler JA, Mu= relli RP, Tang L, Le Grice SFJ. Sensitivity of the C-terminal nuclease doma= in of Kaposi's sarcoma-associated herpesvirus ORF29 to different classes of= active site ligands. Antimicrob Agents Chemother in press, 2017. PubMed link
2017
Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL,= Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Ke= efe BR. Identification of natural products that inhibit the catalytic funct= ion of human tyrosyl-DNA phosphodiesterase (TDP1). SLAS Discovery 22: 1093-= 1105, 2017. PubMed link
Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz MA, Beutler= JA. Growth inhibition of colon cancer and melanoma cells by versiol deriva= tives from a Paraconiothyrium sp. J Nat Prod 80: 2037-2044, 2017. PubMed link
da Cunha MG, Ramos-Junior ES, Franchin M, Taira TM, Beutler JA, Fran= co GCN, Ikegaki M, de Alencar SM, Fukuda SY, Rosalen PL. Effects of cinnamo= yloxy-mammeisin from geopropolis on osteoclast differentiation and Porphyro= monas gingivalis-induced periodontitis. J Nat Prod 80: 1893-1899, 2017.&nbs= p;PubMed link
Elliott DC, Beutler JA, Parker KA. The importance of a 4-alkyl subst= ituent for activity in the englerin series. ACS Med Chem Lett 8: 746=E2=80= =93750, 2017. PubMed link
Gustafson, KR, Chan, STS, Liu, Y, Assigning molecular configuration = by nuclear magnetic resonance. In Modern NMR Approaches for the Structure E= lucidation of Natural Products, Williams, A. J.; Martin, G. E.; Rovnyak, D.= , Eds. Royal Society of Chemistry: Cambridge, England; Vol. 2, pp 39-70, 20= 17.
Hirsch DR, Schiavone DV, Berkowitz AJ, Morrison LA, Masaoka T, Wilso= n JA, Lomonosova E, Zhao H, Patel BS, Datla SH, Hoft SG, Majidi SJ, Pal RK,= Gallicchio E, Tang L, Tavis JE, Le Grice, SFJ, Beutler JA, Murelli, RP. Sy= nthesis and biological assessment of 3,7-dihydroxytropolones. Org & Bio= mol Chem,16: 62-69, 2017. PubMed link
Irie, R, Takada, K, Ise, Y, Ohtsuka, S, Okada, S, Gustafson, KR, Mat= sunaga S Structure revision of poecillastrin C and the absolute configurati= on of the beta-hydroxyaspartic acid residue. Org Lett 19, 5395-5397, 2017. = PubMed link
Jia L, Lin H, Oppenheim J, Howard OMZ., Li J, Fan H, Zhao Z, Farrar = W, Zhang Y, Colburn N, Young M, Li W, Newman D, O'Keefe BR, Beutler J, Liu = J, Hao X, Yang X, Ji, T, White JD. (2017) U.S. National Cancer Institute - = China collaborative studies on Chinese medicine and cancer. J. Natl. Cancer= Inst. Monographs 2017, lgx007. PubMed link
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Stockdale DP, Beutler JA, Wiemer DF. Synthesis of amide isosteres of= schweinfurthin-based stilbenes. Bioorg Med Chem, 25: 5483-5489, 2017. PubMed link
Wu Z, Zhao S, Fash DM, Li Z, Chain WJ, Beutler J. Englerins: A compr= ehensive review. J Nat Prod 80: 771-781, 2017. PubMe= d link
Xu YM, Brooks AD, Wijeratne EM, Henrich CJ, Tewary P, Sayers TJ, Gun= atilaka AA. 17beta-Hydroxywithanolides as sensitizers of renal carcinoma ce= lls to tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL= ) mediated apoptosis: Structure-activity relationships. J Med Chem 60: 3039= -3051, 2017. PubMed link
Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O= 'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS, Jr. Macrophilone A: St= ructure elucidation, total synthesis, and functional evaluation of a biolog= ically active iminoquinone from the marine hydroid Macrorhynchia philip= pina. Org Lett 19: 1726-1729, 2017. PubMed link=
2016
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Cho N, Kim HW, Ransom TT, Smith E, Beutler JA, Sung SH. Preparative = isolation and purification of antiproliferative diarylheptanoids from B= etula platyphylla by high speed counter-current chromatography, Molecu= les, 21: 700, 2016. PubMed link
da Cunha MG, Franco GCN, Franchin M, Beutler JA, de Alencar SM, Ikeg= aki M, Rosalen PL. Prediction of pharmacokinetic and toxicological paramete= rs of a 4-phenyl coumarin isolated from geopropolis: In silico and in vitro= approaches. Tox. Lett., 263: 6-10, 2016. PubMed lin= k
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Darvishi E, Woldemichael GM, Cycloheximide inhibits actin cytoskelet= al dynamics by suppressing signalling via RhoA, J Cell Biochem,, 117(12): 2= 886-2898, 2016. PubMed link
D'erasmo M, Masaoka T, Wilson JA, Hunte, Jr. EM, Beutler JA, Le Gric= e SFJ, Murelli RP. Traceless solid-phase alpha-hydroxytropolone synthesis. = MedChemComm 7: 1789-1792, 2016.
Fako V, Yu Z, Henrich CJ, Ransom TT, Budhu AS, Wang XW. Inhibition o= f wnt/beta-catenin signaling in hepatocellular carcinoma by an antipsychoti= c drug pimozide. Int J Biol Sci 12: 768-775, 2016. P= ubMed link
Fash DM, Peer CJ, Li Z, Talisman IJ, Hayavi S, Ramos JW, Figg WD, Be= utler JA, Chain WJ. Synthesis of a stable and orally bioavailable englerin = analogue, Bioorg.Med.Chem.Lett.,26: 2641-2644, 2016. = PubMed link
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Goey AK, Chau CH, Sissung TM, Cook KM, Venzon DJ, Castro A, Ransom T= R, Henrich CJ, McKee TC, McMahon JB, Grkovic T, Cadelis MM, Copp BR, Gustaf= son KR, Figg WD. Screening and biological effects of marine pyrroloiminoqui= none alkaloids: Potential inhibitors of the HIF-1alpha/p300 interaction, J = Nat Prod, 79(5): 1267-1275, 2016. PubMed link
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Masaoka T, Zhao H, Hirsch DR, D'Erasmo MP, Meck C, Vardano B, Meyers= MJ, Baines J, Beutler JA, Murelli RP, Tang L, Le Grice SFJ. Characterizati= on of the C-terminal nuclease domain of herpes simplex virus pUL15 as a tar= get of nucleotidyltransferase inhibitors. Biochemistry, 55: 809-819, 2016. = PubMed link
Murelli RP, d'Erasmo MP, Hirsch DR, Meck C, Masaoka T, Wilson JA, Zh= ang B, Pal RK, Galicchio E, Beutler JA, Le Grice SFJ. Synthetic alpha-hydro= xytropolones as inhibitors of HIV reverse transcriptase ribonuclease H acti= vity. MedChemComm 7: 1783-1788, 2016.
Osgood CL, Maloney N, Kidd CG, Kitchen-Goosen SM, Segars LE, Gebregi= orgis M, Woldemichael GM, He M, Sankar S, Lessnick SL, Kang MH, Smith MA, T= urner L, Madaj ZB, Winn ME, Nunez LE, Gonzalez-Sabin J, Helman LJ, Moris F,= Grohar PJ. Identification of mithramycin analogs with improved targeting o= f the EWS-FLI1 transcription factor. Clin.Cancer Res., 22 (16): 4105-4118, = 2016. PubMed link
Schmid T, Blees JS, Bajer MM, Wild J, Pescatori L, Crucitti LC, Scip= ione L, Costi R, Henrich CJ, Br=C3=BCne B, Colburn NH, Di Santo R. Diaryl s= ulfides as novel stabilizers of tumor suppressor Pdcd4, PLoS One, 11 (2016)= e0151643. PubMed link
Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, = Medina V, Stoger E, Christou P, Capell T. Rice endosperm is cost-effective = for the production of recombinant griffithsin with potent activity against = HIV. Plant Biotechnol J, 14: 1427-1437, 2016. PubMed = link
Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, = Christou P, Capell T. Cyanovirin-N produced in rice endosperm offers effect= ive pre-exposure prophylaxis against HIV-1 infection in vitro, Plant Cell R= ep, 35: 1309-1319, 2016. PubMed link
Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, = Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, and O'Keefe BR. Discove= ry and characterization of a biologically active non-ATP-competitive p38 MA= P kinase Inhibitor. J.Biomol.Screen. 21: 277-289, 2015. PubMed link
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Yeo D, Huynh N, Beutler JA, Baldwin GS, He H, Nikfarjam M. Glaucarub= inone combined with gemcitabine improves pancreatic cancer survival in a im= munocompetent orthotopic murine model. J.Invest.Surg. 30: 1-7, 2016. PubMed link
Yuan W, Cheng S, Fu W, Zhao M, Li X, Cai Y, Dong J, Huang K, Gustafs= on KR, Yan P. Structurally diverse metabolites from the soft coral Sinu= laria verruca collected in the South China Sea. J.Nat.Prod.,79: 1124-1= 131, 2016. PubMed link
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2015
Beutler JA, Development of englerins for cancer therapy, Czech Chem.= Soc.Symp.Ser., 13: 174-176, 2015.
Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM= , Figg WD, McMahon JB, Schnermann MJ, and Gustafson KR. Structural elucidat= ion and synthesis of eudistidine A: An unusual polycyclic marine alkaloid t= hat blocks interaction of the protein binding domains of p300 and HIF-1alph= a. J.Am.Chem.Soc. 137 (16):5569-5575, 2015. PubM= ed link
Chatterjee A, Ratner DM, Ryan CM, Johnson PJ, O'Keefe BR, Secor WE, = Anderson DJ, Robbins PW, and Samuelson J. Anti-retroviral lectins have mode= st effects on adherence of Trichomonas vaginalis to epithelial cells in vit= ro and on recovery of Tritrichomonas foetus in a mouse vaginal model. PLoS = One 10 (8):e0135340, 2015. PubMed link
da Cunha MG, de Alencar SM, Ikegaki M, Rosalen PL, Ransom TT, and Be= utler JA. Major constituents of Melipona scutellaris geopropolis a= nd their antiproliferative activity. Planta Med. 82: 190-204, 2015.PubMed link
Forcina GC, Castro A, Bokesch HR, Spakowicz DJ, Legaspi ME, Kucera K= , Villota S, Narvaez-Trujillo A, McMahon JB, Gustafson KR, Strobel SA. Stel= liosphaerols A and B, sesquiterpene-polyol conjugates from an Ecuadorian fu= ngal endophyte. J.Nat.Prod., 78: 3005-3010, 2015. PubMed link
Henrich CJ, Brooks AD, Erickson KL, Thomas CL, Bokesch HR, Tewary P,= Thompson CR, Pompei RJ, Gustafson KR, McMahon JB, and Sayers TJ. Withanoli= de E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increas= ing cFLIP degradation. Cell Death.Dis. 6:e1666, 2015.= PubMed link
Henrich CJ, Cartner LK, Wilson JA, Fuller RW, Rizzo AE, Reilly KM, M= cMahon JB, and Gustafson KR. Deguelins, natural product modulators of NF1-d= efective astrocytoma cell growth Identified by high-throughput screening of= partially purified natural product extracts. J.Nat.Prod., 78: 2776-2781, 2= 015. PubMed link
Jak=C3=B3b, M, Lubkowski, J, O'Keefe, BR, and Wlodawer, A. Structure= of a lectin from the sea mussel Crenomytilus grayanus (CGL). Acta= Crystallograf., 71: 1429-1436, 2015. PubMed link=
Jayatunga MKP, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Se= kirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, and Hamilto= n AD. Inhibition of the HIF1alpha-p300 interaction by quinone- and indandio= ne-mediated ejection of structural Zn(II). Eur.J.Med.Chem. 94:509-516, 2015= . PubMed link
Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rod= riguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, and= Fernandez-Romero JA. Griffithsin and carrageenan combination to target HSV= -2 and HPV. Antimicrob.Agents Chemother., 59: 7290-7298, 2015. PubMed link
Ma J, Pawar RS, Grundel E, Mazzola EP, Ridge CD, Masaoka T, Le Grice= SFJ, Wilson JA, Beutler JA, and Krynitsky AJ. Sesquiterpenoid tropolone gl= ycosides from Liriosma ovata. J.Nat.Prod. 78 (2):315-319, 2015.&nb= sp;PubMed link
Moulaei T, Alexandre KB, Shenoy SR, Meyerson J, Krumpe LR, Constanti= ne B, Wilson J, Buckheit R, McMahon JB, Subramaniam S, Wlodawer A, and O' K= eefe BR. Griffithsin tandemers: flexible and potent lectin inhibitors of th= e human immunodeficiency virus. Retrovirology 12 (1):6, 2015. PubMed link
O'Keefe, BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, = Buckheit KW, da Cunha NB, Araujo AC, Lacorte CC, Madeira L, McMahon JB, and= Rech EL. Engineering soya bean seeds as a scalable platform to produce cya= novirin-N, a non-ARV microbicide against HIV. Plant Biotechnol.J. (7):884-8= 92, 2015. PubMed link
Patridge EV, Darnell A, Kucera K, Phillips GM, Bokesch HR, Gustafson= KR, Spakowicz DJ, Zhou L, Hungerford WM, Plummer M, Hoyer D, Narvaez-Truji= llo A, Phillips AJ, Strobel SA, Pyrrolocin A, a 3-decalinoyltetramic acid w= ith selective biological activity, isolated from Amazonian cultures of the = novel endophyte Diaporthales sp. E6927E. Nat.Prod.Comm. 10: 1649-1= 654, 2015. PubMed link
Qin T, Beutler JA, and Porco, Jr JA. Synthesis of dimeric tetrahydro= xanthones with varied linkages: Investigation of shapeshifting properties. = J.Am.Chem.Soc. 137(48): 15225-15233, 2015. PubMe= d link
Shin HJ, Rashid MA, Cartner LK, Bokesch HR, Wilson JA, McMahon JB, a= nd Gustafson KR. Stellettapeptins A and B, HIV-inhibitory cyclic depsipepti= des from the marine sponge Stelletta sp. Tetrahedron Lett. 56 (28)= :4215-4219, 2015. PubMed link
Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutl= er JA, Linehan WM, and Neckers L. Tonantzitlolone cytotoxicity toward renal= cancer cells is PKCtheta- and HSF1-dependent. Oncotarget, 6 (30): 29= 963-29974, 2015. PubMed link
Zhao H, Lin Z, Lynn AY, Vardano B, Beutler JA, Murelli RP, Le Grice = SFJ, and Tang L. Two distinct modes of metal ion binding in the nuclease ac= tive site of a viral DNA-packaging terminase: insight into the two-metal-io= n catalytic mechanism. Nucl.Acids Res.43: 11003-11016, 2015. PubMed link
2014
Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z,= Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, and= Brune B. Characterization of pomiferin triacetate as a novel mTOR and tran= slation inhibitor. Biochem.Pharmacol. 88 (3): 313-321, 2014. PubMed link
Beutler JA, Cragg GM, Iwu M, Newman DJ, and Okunji C. Anticancer Pot= ential of African Plants. The Experience of the United States National Canc= er Institute and National Institutes of Health. Chapter 10 In: Novel Plant = Bioresources: Applications in Food, Medicine and Cosmetics, edited by A. Gu= rib-Fakim,Wiley-Blackwell, p.133-149, 2014.
Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, and Beutle= r JA. Compounds from Simarouba berteroana which inhibit proliferat= ion of NF1-defective cancer cells. Phytochem.Lett. 7 (1):42-45, 2014. PubMed link
Dull AB, George AA, Goncharova EI, Evans JR, Wamiru A, Cartner LK, H= ager GL, and McMahon JB. Identification of compounds by high-content screen= ing that induce cytoplasmic to nuclear localization of a fluorescent estrog= en receptor a chimera and exhibit agonist or antagonist activity in vitro. = J.Biomol.Screen. 19 (2):242-252, 2014. PubMed link
Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, K= rumpe LR, Rose M, Paragas J, Bray M, Olinger Jr. GG, McMahon JB, Hugg= ins J, and O'Keefe BR. The cyanobacterial lectin scytovirin displays potent= in vitro and in vivo activity against Zaire Ebola virus. Antiviral Res. 11= 2: 1-7, 2014. PubMed link
Grkovic T, Blees JS, Bayer MM, Colburn MM, Thomas CL, Henrich CJ, Pe= ach ML, McMahon JB, Schmid T, and Gustafson KR. Tricyclic guanidine alkaloi= ds from the marine sponge Acanthella cavernosa that stabilize the = tumor suppressor PDCD4. Mar.Drugs 12 (8):4593-4601, 2014. PubMed link
Hartung AM, Beutler JA, Navarro HA, Wiemer DF, and Neighbors JD. Sti= lbenes as kappa-selective non-nitrogenous opioid receptor antagonists. J.Na= t.Prod. 77 (2): 311-319, 2014. PubMed link
Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, We= lsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur YH, S= alomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walt= ers MA, Divlianska DB, Roth GP, Wright AE, and Reed JC. Ultra-high-throughp= ut screening of natural product extracts to identify proapoptotic inhibitor= s of bcl-2 family proteins. J.Biomol.Screen. 19 (8):1201-1211, 2014. PubMed link
Jensen SM, Ruscetti FW, Rein A, Bertolette DC, Saucedo CJ, O'Keefe B= R, and Jones KS. Differential inhibitory effects of cyanovirin-N, griffiths= in and scytovirin on entry mediated by envelopes of gammaretroviruses and d= eltaretroviruses. J.Virol. 88 (4):2327-2332, 2014. Pu= bMed link
Kodet JG, Beutler JA, and Wiemer DF. Synthesis and structure activit= y relationships of schweinfurthin indoles. Bioorg.Med.Chem. 22 (8): 2542-25= 52, 2014. PubMed link
McKee TC, Van Wyk AW, and Whitson EL. Natural Product Screening. In:= Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, edited by Fi= gg DWand, and McLeod HL, Totoawa, NJ: Humana Press, 2014, p. 39-67.
Sunassee S, Ransom TT, Henrich CJ, Beutler JA, Covell DG, McMahon JB= , and Gustafson KR. Steroidal alkaloids from the marine sponge Corticiu= m niger that inhibit growth of human colon carcinoma cells. J.Na= t.Prod. 77: 2475-2480, 2014. PubMed link
Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SFJ, O'= Keefe BR, and Schneekloth, Jr JS. Identification of biologically active, HI= V TAR RNA-binding small molecules using small molecule microarrays. J.Am.Ch= em.Soc., 136: 8402-8410, 2014. PubMed link= p>
Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes CA, Baldwin GS, Ni= kfarjam M, and He H. Glaucarubinone and gemcitibine synergistically reduce = pancreatic cancer growth via inhibition of p21-activated kinases. Cancer Le= tt. 346 (2): 264-272, 2014. PubMed link
=2013
Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, = McMahon JB, O'Keefe BR, Chikwamba R, and Morris L. Mechanisms of HIV-1 subt= ype C resistance to GRFT, CV-N and SVN. Virology 446 (1-2):66-76, 2013. PubMed link
Beutler JA. Natural Products as Tools for Discovering New Cancer Tar= gets. In: Natural Products and Cancer Drug Discovery, edited by Ko= ehn FE, New York: Humana Press, 2013, p. 213-237.
Devkota KP, Wilson J, Henrich CJ, McMahon JB, Reilly KM, and Beutler= JA. Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum ar= matum inhibit NF1-defective tumor cell line growth. J.Nat.Prod. 76 (1)= :59-63, 2013. PubMed link
Devkota KP, Covell DG, Ransom TT, McMahon JB, and Beutler JA. Growth= inhibition of human colon carcinoma cells by sesquiterpenoids and tetralon= es of Zygogynum calothyrsum. J.Nat.Prod. 76 (4):710-714, 2013. PubMed link
Dossou KS, Devkota KP, Kavanogh P, Egan J, Beutler JA, and Moaddel R= . Development and preliminary validation of a plate-based CB1/CB2 receptor = functional assay. Anal.Biochem. 437 (2):137-143, 2013. PubMed link
Dossou KKS, Devkota KP, Morton C, Egan JM, Beutler JA, and Moaddel R= . Identification of CB1/CB2 ligands from Zanthoxylum bungeanum. J.Nat= .Prod. 76 (11):2060-2064, 2013. PubMed link
= li>Henrich CJ, Budhu A, Yu Z, Evans JR, Goncharova EI, Ransom TT, Wang = XW, and McMahon JB. High-throughput screening for identification of inhibit= ors of EpCAM-dependent growth of hepatocellular carcinoma cells. Chem.Biol.= Drug Des 82 (2):131-139, 2013. PubMed link
Henrich CJ and Beutler JA. Matching the power of high throughput scr= eening to the chemical diversity of natural products. Nat.Prod.Repts. 30(10= ):1284-1298, 2013. PubMed link
Kanduluru AK, Banerjee P, Beutler JA, and Fuchs PL. A convergent tot= al synthesis of the potent cephalostatin/ritterazine hybrid 25-epi ritteros= tatin GN1N. J.Org.Chem. 78 (18):9085-9092, 2013. PubM= ed link
Masaoka T, Chung S, Carboni P, Wilson JA, Beutler JA, Tocco G, and L= e Grice SFJ. Exploiting drug-resistant enzymes as tools to identify thienop= yrimidinone inhibitors of human immunodeficiency virus reverse transcriptas= e-associated ribonuclease H. J.Med.Chem. 56:5436-5445, 2013. PubMed link
Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee JM, Tre=
pel JB, Beutler JA, Linehan WM, and Neckers LM. Englerin A stimulates PKC t=
heta to inhibit insulin signaling while simultaneously activating HSF1: A c=
ase of pharmacologically induced synthetic lethality. Cancer Cell 23 (2):22=
8-237, 2013. PubMed link
Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Knetem= an N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, and O'Keef= e BR. Antiviral lectins from red and blue-green algae show potent in vitro = and in vivo activity against hepatitis C virus. PLoS One 8 (5):e64449, 2013= . PubMed link
Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, and Porco, Jr JA= . Enantioselective total synthesis and biological evaluation of (+)-kibdelo= ne A and a simplified tetrahydroxanthone analogue. J.Org.Chem. 78 (15= ):7617-7626, 2013. PubMed link
2012
Beutler JA, Cragg GM, and Newman DJ. The National Cancer Institute a= nd Natural Product Based Drug Discovery in Africa. In: Drug Discov= ery in Africa, edited by Chibale K, Davies-Coleman MT, and Masimirembwa C,S= pringer, 2012, p. 29-51.
Hatanaka T, Ohzono S, Park M, Sakamoto K, Tsukamoto S, Sugita R, Ish= itobi H, Mori T, Ito O, Sorajo K, Sugimura K, Ham S, and Ito Y. Human IgA-b= inding peptides selected from random peptide libraries: Affinity maturation= and application in IgA purification. J.Biol.Chem. 287 (51):43126-431= 36, 2012. PubMed link
2011
2010
2009
2008
2007
D.F. Smee, M.K. Wandersee, M.B. Checketts, B.R. O'= Keefe, C. Saucedo, M.R. Boyd, V.P. Mishin, L.V. Gubareva. Influenza A (H1N1= ) virus resistance to cyanovirin-N arises naturally during adaptation to mi= ce and by passage in cell culture in the presence of the inhibitor. Antivir Chem= Chemother.18(6):317-27, 2007. PubMed link=
2006
2005
2004
2003
2002
Charan RD, McKee TC, Boyd MR. Thorectandrols C, D, and E, new sester= terpenes from the marine sponge Thorectandra sp. J Nat Prod 65: 49= 2-495, 2002, doi: 10.1021/np010439k. PubMed= link
=C2=A9 2002-2022 Center for Cancer Research at the National Cancer Insti=
tute.
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