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2017 Publications

Contributions of individual domains to function of the HIV-1 Rev response element.O'Carroll IPThappeta YFan LRamirez-Valdez EASmith SWang YXRein A.J Virol. 2017 Aug 16. pii: JVI.00746-17. doi: 10.1128/JVI.00746-17. [Epub ahead of print]28814520

Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA.

Comas-Garcia MDatta SABaker LVarma RGudla PRRein A.Elife. 2017 Jul 20;6. pii: e27055. doi: 10.7554/eLife.27055.28726630

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.

Li XLSubramanian MJones MFChaudhary RSingh DKZong XGryder BSindri SMo MSchetter AWen XParvathaneni SKazandjian DJenkins LMTang WElloumi FMartindale JLHuarte MZhu YRobles AIFrier SMRigo FCam MAmbs SSharma SHarris CCDasso MPrasanth KVLal A.Cell Rep. 2017 Sep5;20(10):2408-2423. doi: 10.1016/j.celrep.2017.08.041.28877474

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3.

Chaudhary RGryder BWoods WSSubramanian MJones MFLi XLJenkins LMShabalina SAMo MDasso MYang YWakefield LMZhu YFrier SMMoriarity BSPrasanth KVPerez-Pinera PLal A.Elife. 2017 Jun 5;6. pii: e23244. doi: 10.7554/eLife.23244.28580901

Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma.

Dang HTakai AForgues MPomyen YMou HXue WRay DHa KCHMorris QDHughes TRWang XW.Cancer Cell. 2017Jul10;32(1):101-114.e8. doi: 10.1016/j.ccell.2017.06.002.28697339

The Functional Cycle of Rnt1p: Five Consecutive Steps of Double-Stranded RNA Processing by a Eukaryotic RNase III.

Song HFang XJin LShaw GXWang YXJi X.Structure. 2017 Feb 7;25(2):353-363. doi: 10.1016/j.str.2016.12.013. Epub 2017 Jan 19.28111020
Virus-Mediated Alterations in miRNA Factors and Degradation of Viral miRNAs by MCPIP1.  Happel CRamalingam DZiegelbauer JM.PLoS Biol. 2016 Nov 28;14(11):e2000998. doi: 10.1371/journal.pbio.2000998. eCollection 2016 Nov.27893764

Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection.

Serquiña AKPKambach DMSarker OZiegelbauer JM.MBio. 2017 Jul 11;8(4). pii: e00576-17. doi: 10.1128/mBio.00576-17.28698273



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Protocol for a nationwide survey of primary health care in China: the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) MPP (Million Persons Project) Primary Health Care Survey.
Related Articles

Protocol for a nationwide survey of primary health care in China: the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) MPP (Million Persons Project) Primary Health Care Survey.

BMJ Open. 2017 Aug 28;7(8):e016195

Authors: Su M, Zhang Q, Lu J, Li X, Tian N, Wang Y, Yip W, Cheng KK, Mensah GA, Horwitz RI, Mossialos E, Krumholz HM, Jiang L

INTRODUCTION: China has pioneered advances in primary health care (PHC) and public health for a large and diverse population. To date, the current state of PHC in China has not been subjected to systematic assessments. Understanding variations in primary care services could generate opportunities for improving the structure and function of PHC.
METHODS AND ANALYSIS: This paper describes a nationwide PHC study (PEACE MPP Primary Health Care Survey) conducted across 31 provinces in China. The study leverages an ongoing research project, the China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project (MPP). It employs an observational design with document acquisition and abstraction and in-person interviews. The study will collect data and original documents on the structure and financing of PHC institutions and the adequacy of the essential medicines programme; the education, training and retention of the PHC workforce; the quality of care; and patient satisfaction with care. The study will provide a comprehensive assessment of current PHC services and help determine gaps in access and quality of care. All study instruments and documents will be deposited in the Document Bank as an open-access source for other researchers.
ETHICS AND DISSEMINATION: The central ethics committee at the China National Centre for Cardiovascular Disease (NCCD) approved the study. Written informed consent has been obtained from all patients. Findings will be disseminated in future peer reviewed papers, and will inform strategies aimed at improving the PHC in China.

PMID: 28851781 [PubMed - indexed for MEDLINE]

Virulence determinants associated with the Asian community-associated methicillin-resistant Staphylococcus aureus lineage ST59.
Related Articles

Virulence determinants associated with the Asian community-associated methicillin-resistant Staphylococcus aureus lineage ST59.

Sci Rep. 2016 06 14;6:27899

Authors: Li M, Dai Y, Zhu Y, Fu CL, Tan VY, Wang Y, Wang X, Hong X, Liu Q, Li T, Qin J, Ma X, Fang J, Otto M

Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in the United States and are on a global rise. However, what defines virulence particularly of global CA-MRSA lineages is poorly understood. Threatening a vast population, the predominant Asian CA-MRSA lineage ST59 is of major epidemiological importance. However, there have been no molecular analyses using defined virulence gene deletion mutants in that lineage as of yet. Here, we compared virulence in skin, lung, and blood infection models of ST59 CA-MRSA isolates with geographically matched hospital-associated MRSA isolates. We selected a representative ST59 CA-MRSA isolate based on toxin expression and virulence characteristics, and produced isogenic gene deletion mutants of important CA-MRSA virulence determinants (α-toxin, PSM α, Agr) in that isolate for in-vitro and in-vivo analyses. Our results demonstrate strongly enhanced virulence of ST59 CA-MRSA over hospital-associated lineages, supporting the notion that enhanced virulence is characteristic for CA-MRSA. Furthermore, they show strong and significant contribution of Agr, α-toxin, and PSMα to pathogenesis of ST59 CA-MRSA skin, lung, and blood infection, emphasizing the value of drug development efforts targeted toward those virulence determinants.

PMID: 27296890 [PubMed - indexed for MEDLINE]

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Last updated by Hooper, Laura (NIH/NCI) [E] on Sep 27, 2017