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A postdoctoral position is available in the RNA Mediated Gene Regulation Section of the RNA Biology Laboratory (RBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), located in Frederick, MD. The candidate will perform basic research to develop small RNA-based therapeutics for cancer treatment.


Our goal is to uncover the roles of non-coding RNA in gene regulation in mammalian systems and to apply those in developing effective treatments for a variety of diseases. Using genetic functional studies in living cells and animals, together with biochemical and next-generation sequencing (NGS) approaches, our laboratory will focus on unraveling the mechanisms of small non-coding RNAs biogenesis, post-transcriptional modifications, and biological functions. This information will be used to test novel RNA-based approaches designed to alter gene expression with improved safety, off-targeting, and potency profiles, which can then be used as tools for biological discovery and therapeutics.  


MicroRNA (miRNA), as a small non-coding RNA, plays essential roles in gene regulation networks. We are particularly interested in designing miRNA-based approaches for cancer treatment. Taking advantage of the mechanistic insights discovered in our lab, the successful candidate will develop a series of small RNA based anti-cancer therapeutics which would be used in potentially gene-therapy setting.


Interested candidates must have a Ph.D. and/or a M.D. and have less than two (2) years of postdoctoral experience.  Applicants must have a strong background in molecular biology and biochemistry.  Experience with RNA research and/or gene therapy is a strong plus. The stipend starts at $49,900, commensurate with experience.


To apply, send a cover letter, CV including bibliography, and contact information for three references to the following address:


Dr. Shuo Gu
RNA Mediated Gene Regulation Section, GRCBL, CCR, NCI
Building 539, Room 222

1050 Boyles Street

Frederick, MD  21702


This position is subject to a background investigation.  The NIH is dedicated to building a diverse community in its training and employment programs.


DHHS, NIH, and NCI are Equal Opportunity Employers

Last updated by Wolin, Sandra (NIH/NCI) [E] on Jun 16, 2017