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PI: Yamini Dalal, Ph.D.
Lab/Branch/Program: 
Laboratory of Receptor Biology and Gene Expression
Campus: 
NCI at Bethesda
Research Area Keywords: 
epigenetics, chromatin structure, histone variants, ncRNA, cancer

Position Description: 
Postdoctoral positions are available in the Chromatin Structure and Epigenetic Mechanisms group at the National Cancer Institute, National Institutes of Health. The primary focus of our lab is to investigate how epigenetic mechanisms driven by chromatin structure influence cancer development. We have recently discovered that a previously unknown long non-coding RNA is involved in the proper organization and function of centromeric chromatin, and that a centromeric histone variant is over-expressed in colon cancer cells, whereupon it invades ectopic loci. The successful candidates will design and pursue a new and exciting avenue of research, in which the interplay between ncRNA and histone variants commonly found mis-regulated in a variety of human tumors will be interrogated to dissect biological consequences. Positions will remain open until suitable candidates are found.

Number of Positions: 
1
C.V. Required: 
Yes
Number of References Required: 
3
Bibliography Required: 
Yes
Experience Required: 
The ideal applicant should posses a recent Ph.D. degree (within 12 months of application) from an accredited institution and solid thesis publications in peer-reviewed journals. Due to the nature of the experiments involved, the candidate should posses background in biochemistry, genetics or cell biology, and be comfortable with adapting techniques involving primary cell culture, chromatin immunoprecipitation, Western blotting, RT-PCR, immunofluorescence, AFM, FISH etc.

How To Apply: 
Interested candidates should send a C.V. with the names and contact information of 3 references and a brief statement describing past and future research interests to Dr. Yamini Dalal at dalaly@mail.nih.gov.

Last updated by Ziegelbauer, Joseph (NIH/NCI) [E] on Apr 17, 2015