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CCR-DCEG Collaborative Award


The CCR and the DCEG pursue highly complementary approaches to cancer research and prevention. To foster integrative studies that take advantage of the expertise in population-based epidemiological studies present in the DCEG and the basic biology and clinical expertise in CCR, we are seeking proposals for the formation of joint CCR-DCEG research teams to perform high-impact collaborative research projects in the area of cancer mechanism, diagnosis, prognosis, susceptibility, predisposition, or prevention.

Each Team will consist of at least one PI each from CCR and DCEG with clearly distinct and/or complementary expertise. Proposal must contain a clearly defined, well-integrated, population-based epidemiological component and a basic research or clinical component. Preliminary data to demonstrate impact and feasibility of the study are recommended but are not essential. Distinctiveness from ongoing PI-based activities needs to be clearly demonstrated.

Selection Criteria

Key criteria for evaluation of proposals are:

  • Potential impact: Successful projects will lead to ground-breaking new insights into predisposition, susceptibility or mechanisms of cancer and may result in the development of new diagnostic, prognostic, therapeutic or preventative approaches.
  • CCR-DCEG complementarity: The specific expertise of the CCR and DCEG investigators should be highly complementary and the activities should take full advantage of the unique resources in the two divisions.
  • Degree of innovation: The resulting research output must be highly innovative and have potential for transformational advances.
  • Feasibility: The PIs must provide evidence for the feasibility of the proposed studies and demonstrate relevant expertise amongst team-members. Preliminary data to demonstrate feasibility is encouraged, but not required.
  • Milestones: The proposal should list clearly defined milestones and identify at least annual go/no-go decision points.


Each proposal requires the participation of at least one CCR and one DCEG collaborator. Lead applicants must be a CCR intramural Tenure-track PI, Tenured PI, Senior Clinician or Senior Scientist.  Those in the Physician-Scientist Early Investigator (PEI) program can apply but must include a tenured PI as a co-PI.  Staff Scientists who are site-visited and have independent budgets (CANs) are also eligible. For submission purposes, DCEG PIs are to be listed as key personnel in the application. Non-NCI researchers can act as collaborators but can not receive funds. Please click here for more specifics on who may apply.


Funding will be provided for 3 years with up to $175,000 per year to cover personnel and/or supply costs. A detailed budget is required to justify requested funds.

Review Process

Review of proposals will occur in two stages. After initial review of Letters of Intent (LOI), shortlisted proposals (approximately 20% of LOIs) will be invited for full review.

LOI and invited proposals will be reviewed by the DCEG leadership and the CCR Science Board.

Application process and format

LOI and invited proposals are to be submitted to ProposalCentral.

Click for instructions on preparing an application.

Important Deadlines

Invited Proposals are due on December 2, 2020

Last updated by Linnekin, Diana (NIH/NCI) [E] on Oct 19, 2020