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The Center for Cancer Research announces a course for researchers using animal models: Mouse Research Models (MRM) or Mouse 101


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Mouse research models play an important role in cancer research. Technologies available today allow researchers to create mouse models of cancer by transferring new genes into animals or inactivating existing genes. Mouse research models can be used to study the changes associated with tumor development, test new approaches to detection and diagnosis and to evaluate prevention and treatment strategies. MRM/Mouse 101 will provide an overview of the procedures used at NIH to conduct research using mice and explore how mouse research models can be used in cancer research. The course is designed for fellows, technicians, and investigators who plan to conduct experiments using mouse research models at NIH.

Location and Time:
The MRM course will be held on September 21, October 5, 19 and 26 from 9:00 a.m. – 1:00 p.m. in Building 45, Natcher Conference Center, Balcony A/B* with video-conference to Frederick National Laboratory for Cancer Research (FNL), Building 549 Auditorium.

* Balcony B on 9/21; Balcony A on 10/5, 10/19, and 10/26

Several hands-on training modules in various common mouse techniques will be offered to small groups on additional dates to be announced at the course.

Archived Presentations:
The presentations included in this course will be recorded and archived at a later date.

Register by clicking on the link at the top of the page. The deadline for registration is September 16, 2015. For more information contact Romi Sawhney by email at ( or by phone (301-496-4345). There is no fee for this course but seating is limited. Registration is on first come first serve basis. Certificates of completion will be provided to registrants who attend the course.

Course Syllabus:

September 21, 2015, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony B




Commonly Used Mouse Strains

Jeff Green

How to Choose your Animal Model

Peter Aplan

General Experimental Design

Linda Byrd

Effective Colony Management

Wendy DuBois

October 5, 2015, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony A


Introduction to Mouse Genetics

Karlyne Reilly

Genetic Approaches to Generating Mice for Biological and Drug Therapy Studies

Lino Tessarollo

      • Complex and inducible

Mark Lewandoski

Drug Studies Using Mouse Models

Melinda Hollingshead


Charles Halsey

October 19, 2015, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony A


KOMP (Knockout Mouse Project)

Colin Fletcher

In vivo Imaging -


      • Optical imaging, MRI, US, etc.

Peter Choyke

      • Intravital microscopy

Roberto Weigert

Practical Aspects of the Mouse Immune System

Nick Restifo

      • Flow cytometry
Karen Wolcott

Overview of Core Animal Services


      • LASP
Rick Bedigian
      • CAPR
Serguei Kozlov

October 26, 2015, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony A


Introduction and Overview of Survival Surgery
(Microsurgery, bone marrow transplant, orthotropic transplants, etc.)

Bob Hoyt

Overview of Sentinel and Rodent Health Monitoring Program and Import Rules    

Melody Roelke-Parker

Basic Mouse Diseases and Their Possible Effects on Research

Josh Kramer

Preparation of the NCI Animal Study Proposal

Rebekah Smith/Angela Stahl

Common Techniques used in Cancer Models

Matt Breed


Presentations from September 21, 2015 (Day 1)


Presentations from October 5, 2015 (Day 2)

Presentations from October 19, 2015 (Day 3) 

Presentations from October 19, 2015 (Day 3) 


Archived Presentations: Day 1 – 9/21/15

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