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The Center for Cancer Research announces a course for researchers using animal models: Mouse Research Models (MRM) or Mouse 101


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Mouse research models play an important role in cancer research. Technologies available today allow researchers to create mouse models of cancer by transferring new genes into animals or inactivating existing genes. Mouse research models can be used to study the changes associated with tumor development, test new approaches to detection and diagnosis and to evaluate prevention and treatment strategies. MRM/Mouse 101 will provide an overview of the procedures used at NIH to conduct research using mice and explore how mouse research models can be used in cancer research. The course is designed for fellows, technicians, and investigators who plan to conduct experiments using mouse research models at NIH.

Location and Time:
The MRM course will be held on May 22, May 29, June 5 and June 12 from 9:00 a.m. – 1:00 p.m. in Building 45, Natcher Conference Center, Balcony B with video-conference to Frederick National Laboratory for Cancer Research (FNL), Building 549 Auditorium.

Several hands-on training modules in various common mouse techniques will be offered to small groups on additional dates to be announced at the course.

Archived Presentations:
The presentations included in this course will be recorded and archived at a later date.

Register by clicking on the link at the top of the page. The deadline for registration is May 15, 2018. For more information contact Kathy Divi by email at ( or by phone (240-760-7749). There is no fee for this course but seating is limited. Registration is on first come first serve basis. Certificates of completion will be provided to registrants who attend the course.

Course Syllabus:

May 22, 2018, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony B




Commonly Used Mouse Strains

Chi-Ping Day

General Experimental Design

Jack Greiner

Effective Colony Management

Wendy DuBois

Drug Studies Using Mouse Models

Melinda Hollingshead

May 29, 2018, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony B


How to Choose Your Animal Model

Remy Bosselut

Introduction to Mouse Genetics

Karlyne Reilly

Genetic Approaches to Generating Mice for Biological and Drug Therapy Studies

Lino Tessarollo

Complex and Inducible Construct Design for Mouse Models

Mark Lewandoski


Hibret Amare Adissu

June 5, 2018, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony B


In Vivo Imaging


      • Optical imaging, MRI, US, etc.


      • Intravital microscopy


Practical Aspects of the Mouse Immune System

Flow cytometry 
 Overview of core animal services


      • LASP
      • CAPR

June 12, 2018, 9:00 a.m. to 1:00 p.m. - Bldg. 45 Balcony B


Introduction and Overview of Survival Surgery
(Microsurgery, bone marrow transplant, orthotropic transplants, etc.)


Common Techniques used in Cancer Models


Basic Mouse Diseases and Their Possible Effects on Research


Preparation of the NCI Animal Study Proposal 



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