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The Laboratory of Experimental Carcinogenesis (LEC) is comprised of the Cellular and Molecular Biology Section (CMBS) and two CCR Cores, the Confocal Microscopy Core and the DNA Sequencing and Digital Gene Expression Core. The LEC supports an integrated research program designed to elucidate the cellular, genetic and molecular changes associated with both experimentally induced carcinogenesis and human cancer, to define the molecular mechanisms involved, and to delineate pathways that may provide novel targets for treatment and prevention of human cancer. Studies are performed both in experimental animals, especially transgenic and knockout mouse models, in cell culture and on tissue and cells obtained from patients. The research of the CMBS, headed by Snorri S. Thorgeirsson, is devoted to two major areas: (1) molecular pathogenesis, classification and treatment of human liver cancer and (2) adult liver and cancer stem cells. The two CCR core facilities are OPEN to all NCI intramural investigators: