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NCI Center of Excellence in Immunology

The Center of Excellence in Immunology (CEI) is one of 5 Centers of Excellence within the NCI Intramural Research Program (IRP). These Centers are multi-disciplinary venues that generate connections among diverse intellectual, financial, and physical resources within the IRP to help develop new initiatives, projects, and collaborations that reduce the burden of cancer.

Mission

The Mission of the Center of Excellence in Immunology is to foster discovery, development, and delivery of novel immunologic approaches for the prevention and treatment of cancer and cancer-associated viral diseases.

Objectives

  • Provide a format to integrate the diverse fields within immunology and facilitate translation of basic research discoveries into successful treatments
  • Serve as a distinctive think tank
  • Blend basic and clinical scientific expertise and perspectives
  • Merge disciplines and promote new perspectives
  • Provide attractive partnership options for academia and pharmaceutical companies
  • Promote interaction of immunologists in the intra- and extramural communities

 

Selected Activities


Selected Recent Publications

  

Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial Christopher R Heery, Geraldine O’Sullivan-Coyne, Ravi A Madan, Lisa Cordes, Arun Rajan, Myrna Rauckhorst, Elizabeth Lamping, Israel Oyelakin, Jennifer L Marté, Lauren M Lepone, Renee N Donahue, Italia Grenga, Jean-Marie Cuillerot, Berend Neuteboom, Anja von Heydebreck, Kevin Chin, Jeffrey Schlom, James L Gulley  Lancet Oncology, March 31, 2017 online

Avelumab for patients with previously treated metastatic recurrent non-small-cell lung cancer (JAVELIN Solid Tumor): dose-expansion cohort of a multicentre, open-label, phase 1b trial James L Gulley, Arun Rajan, David R Spigel, Nicholas Iannotti, Jason Chandler, Deborah J L Wong, Joseph Leach, W Jeff Edenfield, Ding Wang, Hans Juergen Grote, Anja von Heydebreck, Kevin Chin, Jean-Marie Cuillerot, Karen Kelly  Lancet Oncology, March 31, 2017 online

Recruitment of calcineurin to the TCR positively regulates T cell activation. Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD. Nat Immunol. Feb 2017

Cell Transfer Therapy Targeting Mutant KRAS in Cancer. Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, Jia L, Pasetto A, Zheng Z, Ray S, Groh EM, Kriley IR, Rosenberg SA. N Engl J Med. Dec 2016

Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors. Kimura MY, Thomas J, Tai X, Guinter TI, Shinzawa M, Etzensperger R, Li Z, Love P, Nakayama T, Singer A. Nature Immunology. Dec 2016.

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. Eggert T, Wolter K, Ji J, Ma C, Yevsa T, Klotz S, Medina-Echeverz J, Longerich T, Forgues M, Reisinger F, Heikenwalder M, Wang XW, Zender L, Greten TF. Cancer Cell. Oct 2016.

Ionic immune suppression within the tumour microenvironment limits T cell effector function. Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP. Nature Sep 2016

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.Clever D, Roychoudhuri R, Constantinides MG, Askenase MH, Sukumar M, Klebanoff CA, Eil RL, Hickman HD, Yu Z, Pan JH, Palmer DC, Phan AT, Goulding J, Gattinoni L, Goldrath AW, Belkaid Y, Restifo NP.   Cell  Aug 2016

Hierarchical nanostructure and synergy of multimolecular signalling complexes. Sherman E, Barr VA, Merrill RK, Regan CK, Sommers CL, Samelson LE. Nature Communications Jul 2016