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Center of Excellence in Chromosome Biology

Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. Its goals are a comprehensive understanding of the mechanisms involved in chromosome function, and the correction of aberrations in these processes that lead to disease.

The Center of Excellence in Chromosome Biology (CECB), open to all NCI intramural investigators, brings together experts from fields such as dynamics of chromatin structure and function; epigenetics and gene expression; chromosome segregation and cell division; DNA replication, repair, and recombination; chromosome organization and gene localization; and nuclear protein interaction dynamics. The CECB integrates the intellectual and physical resources within NCI's Intramural Research Program to support outstanding research in chromosome biology. 


  • Promote interaction and collaboration among researchers within the NCI, NIH, and beyond

  • Promote advances and opportunities for research in chromosome biology

  • Leverage cutting-edge tools, approaches, and resources to advance chromosome biology as it applies to cancer research

  • Train young investigators to address complex scientific questions through collaboration and multi-disciplinary approaches

Special Notices/Announcements

Upcoming Symposia/Seminars of Interest

CECB Workshops

December 8, 2022
Time: 9am-12:50pm

In person:

Building 49, Room 1A51/1A59, Bethesda campus

WebEx Event Information:

When it's time, join the meeting.

Keynote Seminars:

“Capturing the C in Centromeres” 

William C. Earnshaw, Ph.D.

Professor, University of Edinburgh


“Molecular CAT scans of cell nuclei by cryo-ET” 

Lu Gan, Ph.D.

Associate Professor, National University of Singapore


Selected short talks:

“Single-molecule tracking reveals two low-mobility states for chromatin and transcriptional regulators within the nucleus”

Kaustubh Wagh, Ph.D.

Predoctoral Fellow, Laboratory of Receptor Biology and Genome expression, CCR, NCI

“Active DNA demethylation promotes cell fate specification and the DNA damage response”

Dongpeng Wang, Ph.D.

Visiting Fellow, Laboratory of Genome Integrity, CCR, NCI


Biology and Biophysics of the Nucleus

October 20-21, 2022



Last updated by Metzger, Meredith (NIH/NCI) [E] on Nov 21, 2022