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Center For Cancer Research DCEG National Cancer Institute

NCI Center of Excellence in Chromosome Biology

Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. Its goals are a comprehensive understanding of the mechanisms involved in chromosome function, and the correction of aberrations in these processes that lead to disease.

The Center of Excellence in Chromosome Biology (CECB), open to all NCI intramural investigators, brings together experts from fields such as dynamics of chromatin structure and function; epigenetics and gene expression; chromosome segregation and cell division; DNA replication, repair, and recombination; chromosome organization and gene localization; and nuclear protein interaction dynamics. The CECB integrates the intellectual and physical resources within NCI's Intramural Research Program to support outstanding research in chromosome biology. Download our brochure


  • Promote interaction and collaboration among researchers within the NCI, NIH, and beyond
  • Promote advances and opportunities for research in chromosome biology
  • Leverage cutting-edge tools, approaches, and resources to advance chromosome biology as it applies to cancer research
  • Train young investigators to address complex scientific questions through collaboration and multi-disciplinary approaches
Special Notices/Announcements


Gordon Hager received the 2015 Society for Endocrinology Transatlantic Medal

Congratulations to Shiv Grewal, on his election to the National Academy of Sciences and the American Association for the Advancement of Science.

 Susan Gottesman has won the National Academy of Sciences 2015 Selman A. Waksman Award in Microbiology

Tom Misteli was awarded the 2014 Robert Feulgen Prize by the Society for Histochemistry.

Gordon Hager has been appointed as the Hans Christian Anderson Visiting Professor at the Univ. of Southern Denmark for 2014-2016


CECB in the Press

Stop Stalling: Mus81 Required for Efficient Replication In the Journals

RNA Rules: The Many Faces and Functions of Ribonucleic Acids Connections vol 8 no 1

Tools of the Trade Connections vol 8 no 1

A key molecular defect in a childhood gastrointestinal tumor may have important diagnostic implications  NCI press release

NCI scientists find protective mechanism against cancer in the cells of progeria patients NCI press release

p53 Regulates Bone Differentiation and Osteosarcoma Formation In the Journals

Finding Order in Randomness: Single-Molecule Studies Reveal Stochastic RNA Processing In the Journals

Tumor-Protective Mechanism Identified from Premature Aging Disease In the Journals

Histone Variant Regulates DNA Repair via Chromatin Condensation In the Journals

DNA Damage Repair Factors have a Tumor Promoting Role in MLL-fusion Leukemia In the Journals

Flipping the NF-κB Switch in Macrophages In the Journals

Genome-wide overlap in the binding location and function of chromatin-remodeling proteins In the Journals

Global Amplification: A New Look at Transcriptional Regulation Connections vol 7 no 2

NIH scientists visualize how cancer chromosome abnormalities form in living cells NCI press release

CECB: Capturing Dynamic Changes in Chromatin Connections vol 7 no 1

Upcoming Seminars of Interest

11/10/2015Sharon Dent9:00 AM Bldg 40:1201/1203

Workshop on Chromosome Biology

June 10, 2015
Location: Lister Hill

This Workshop is sponsored by the NCI's Center of Excellence in Chromosome Biology (CECB) and the NIH Chromatin Interest Group. The aim is to foster interaction among major laboratories in the areas of chromosome biology, and to enhance the education and development of junior investigators and fellows in CECB laboratories. With rapid advances and new technologies in the field, continuous interaction with members of the international community is critical to insure the most effective development of our research programs.

Keynote Presentation: Rodney Rothstein
Increased chromosome mobility and the homology search during double-strand break repair

POSTDOC SPEAKERS (speakers not in order of presentation):
Sandip De (Kassis Lab). "Transcriptional silencing by Polycomb group proteins:  the stabilizing effect of home."

Tineke Lenstra (Larson Lab). "Single-molecule imaging reveals a switch between spurious and functional ncRNA transcription."

Kentaro Ohkuni (Basrai Lab). "SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant and prevents its mislocalization to euchromatin."

Andre Stanlie (Nussenzweig Lab). "Extra-telomeric role of shelterin component TRF2 in immunoglobulin class switch recombination."

Current jobs in the CCR



Added by Shilling, Jeffrey (NIH/NCI) [E] , last edited by Boersma, Brenda (NIH/NCI) [E] on Dec 01, 2015 09:19