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Center For Cancer Research DCEG National Cancer Institute

NCI Center of Excellence in Chromosome Biology

Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. Its goals are a comprehensive understanding of the mechanisms involved in chromosome function, and the correction of aberrations in these processes that lead to disease.

The Center of Excellence in Chromosome Biology (CECB), open to all NCI intramural investigators, brings together experts from fields such as dynamics of chromatin structure and function; epigenetics and gene expression; chromosome segregation and cell division; DNA replication, repair, and recombination; chromosome organization and gene localization; and nuclear protein interaction dynamics. The CECB integrates the intellectual and physical resources within NCI's Intramural Research Program to support outstanding research in chromosome biology. Download our brochure


  • Promote interaction and collaboration among researchers within the NCI, NIH, and beyond
  • Promote advances and opportunities for research in chromosome biology
  • Leverage cutting-edge tools, approaches, and resources to advance chromosome biology as it applies to cancer research
  • Train young investigators to address complex scientific questions through collaboration and multi-disciplinary approaches
Special Notices/Announcements


Michael Lichten was elected to the  American Academy of Arts and Sciences

Gordon Hager was awarded the 2015 Society for Endocrinology Transatlantic Medal by the British Society for Endocrinology

Sheue-yann Cheng received the John B. Stanbury Thyroid Pathophysiology Medal Award from the American Thyroid Association

Tom Misteli to receive the 2016 Herman Beerman Award by the Society for Investigative Dermatology


CECB in the Press

Dynamic Regulation of FoxA1 by Steroid Receptors In the Journals

Histone Variant H2A.X Regulates Colon Cancer EMT In the Journals

Cellular factors that shape the 3D landscape of the genome identified NCI press release

Gene Positioning as a Diagnostic Marker in Prostate Cancer In the Journals

Noncoding RNA Shows Context-Dependent Function In the Journals

Regulatory RNA Key Player in p53-Mediated Apoptosis in Embryonic Stem Cells In the Journals

Paradigm Shift in Thyroid Hormone Mechanism of Action In the Journals

Splicing Modulation as a Potential Treatment for Vemurafenib-Resistant Melanoma In the Journals

Stop Stalling: Mus81 Required for Efficient Replication In the Journals

Upcoming Seminars of Interest

Workshop on Chromosome Biology

June 8, 2016
Location: Bldg 40 1201/1203

This Workshop is sponsored by the NCI's Center of Excellence in Chromosome Biology (CECB) and the NIH Chromatin Interest Group. The aim is to foster interaction among major laboratories in the areas of chromosome biology, and to enhance the education and development of junior investigators and fellows in CECB laboratories. With rapid advances and new technologies in the field, continuous interaction with members of the international community is critical to insure the most effective development of our research programs.

Keynote Presentation:

“Transcription factor/chromatin interactions: Integrating genome-wide and real-time dynamic datasets”
Gordon Hager
Chief of the Laboratory of of Receptor Biology and Gene Expression

POSTDOC SPEAKERS (speakers not in order of presentation):

Dr. Ritu Chaudhary, Laboratory of Dr. Ashish Lal, Genetics Branch, CCR, NCI
Title: “Regulation of chemoresistance by a novel p53-regulated long noncoding RNA”

Dr. Darpan Medhi, Laboratory of Dr. Michael Lichten, Laboratory of Biochemistry and Molecular Biology, NCI
Title: “A Tale of Two Loci, Genome location is a primary determinant of meiotic recombination biochemistry”

Dr. Tao Deng, Laboratory of Michael Bustin, Laboratory of Metabolism, NCI
Title: "Interplay between architectural proteins in stem cell chromatin epigenetically regulates nueural development"

Dr. Martin Zofal, Laboratory of Shiv Grewal, Laboratory of Biochemistry and Molecular Biology, NCI
Title: “Shelterin-targeted assembly of facultative heterochromatin”



Added by Shilling, Jeffrey (NIH/NCI) [E] , last edited by Boersma, Brenda (NIH/NCI) [E] on May 27, 2016 12:42 PM