Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. Its goals are a comprehensive understanding of the mechanisms involved in chromosome function, and the correction of aberrations in these processes that lead to disease.
The Center of Excellence in Chromosome Biology (CECB), open to all NCI intramural investigators, brings together experts from fields such as dynamics of chromatin structure and function; epigenetics and gene expression; chromosome segregation and cell division; DNA replication, repair, and recombination; chromosome organization and gene localization; and nuclear protein interaction dynamics. The CECB integrates the intellectual and physical resources within NCI's Intramural Research Program to support outstanding research in chromosome biology. Download our brochure
Objectives
- Promote interaction and collaboration among researchers within the NCI, NIH, and beyond
- Promote advances and opportunities for research in chromosome biology
- Leverage cutting-edge tools, approaches, and resources to advance chromosome biology as it applies to cancer research
- Train young investigators to address complex scientific questions through collaboration and multi-disciplinary approaches
CECB in the Press
NIH scientists visualize how cancer chromosome abnormalities form in living cells NCI press release
CECB: Capturing Dynamic Changes in Chromatin Connections vol 7 no 1
Upcoming Seminars of Interest
March 31, 2014Bldg 50 1st Floor Conference Room
2:30-3:30PM
Karen Oegema, Ph.D.
Professor of Cellular and Molecular Medicine at the University of California, San Diego
Laboratory of Mitotic Mechanisms at Ludwig Institute for Cancer Research
"Whither centrioles? A chemical biology approach to centriole function in mammals"
Host: Yamini Dalal (dalaly@mail.nih.gov)
May 14, 2014
Bldg 50 1st Floor Conference Room
12:00-1:00PM
Indika Rajapakse, Ph.D.
Assistant Professor, Department of Computational Medicine & Bioinformatics, Medical School
Assistant Professor, Department of Mathematics, College of Literature, Science, and the Arts
University of Michigan
"Controllability of the 4D Genome"
Host: Thomas Ried (riedt@mail.nih.gov)
Workshop on Chromosome Biology
Wednesday June 4, 2014, 9AM to 12:00PM
This Workshop is sponsored by the NCI's Center of Excellence in Chromosome Biology (CECB) and the NIH Chromatin Interest Group. The aim is to foster interaction among major laboratories in the areas of chromosome biology, and to enhance the education and development of junior investigators and fellows in CECB laboratories. With rapid advances and new technologies in the field, continuous interaction with members of the international community is critical to insure the most effective development of our research programs.
Keynote Presentation: "Title to be announced"
Roger Greenberg, University of Pennsylvania
Host: Philipp Oberdoerffer
Postdoc speakers:
TBD
