Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. Its goals are a comprehensive understanding of the mechanisms involved in chromosome function, and the correction of aberrations in these processes that lead to disease.
The Center of Excellence in Chromosome Biology (CECB), open to all NCI intramural investigators, brings together experts from fields such as dynamics of chromatin structure and function; epigenetics and gene expression; chromosome segregation and cell division; DNA replication, repair, and recombination; chromosome organization and gene localization; and nuclear protein interaction dynamics. The CECB integrates the intellectual and physical resources within NCI's Intramural Research Program to support outstanding research in chromosome biology. Download our brochure
Objectives
- Promote interaction and collaboration among researchers within the NCI, NIH, and beyond
- Promote advances and opportunities for research in chromosome biology
- Leverage cutting-edge tools, approaches, and resources to advance chromosome biology as it applies to cancer research
- Train young investigators to address complex scientific questions through collaboration and multi-disciplinary approaches
Awards
Congratulations to Shiv Grewal, on his election to the National Acadamy of Sciences and the American Association for the Advancement of Science.
Susan Gottesman was elected to EMBO.
Tom Misteli was awarded the 2014 Robert Feulgen Prize by the Society for Histochemistry.
Gordon Hager has been appointed as the Hans Christian Anderson Visiting Professor at the Univ. of Southern Denmark for 2014-2016
CECB in the Press
Histone Variant Regulates DNA Repair via Chromatin Condensation In the Journals
DNA Damage Repair Factors have a Tumor Promoting Role in MLL-fusion Leukemia In the Journals
Flipping the NF-κB Switch in Macrophages In the Journals
Genome-wide overlap in the binding location and function of chromatin-remodeling proteins In the Journals
Global Amplification: A New Look at Transcriptional Regulation Connections vol 7 no 2
NIH scientists visualize how cancer chromosome abnormalities form in living cells NCI press release
CECB: Capturing Dynamic Changes in Chromatin Connections vol 7 no 1
Register now for the
NCI Symposium on Chromosome Biology: Chromatin, ncRNA, Methylation & Disease
April 16-17, 2015
Natcher Conference Center, Bethesda, Maryland
Speakers to include (tentatively):
| Shelley Berger | University of Pennsylvania |
| Emily Bernstein | Mt. Sinai Hospital |
| Laurie Boyer | MIT |
| Michael Bustin | NIH |
| Rafael Casellas | NIH |
| Julie Cooper | NIH |
| Victor Corces | Emory University |
| Yamini Dalal | NIH |
| Dan Durocher | University of Toronto |
| Joseph Ecker | Salk Institute |
| Karl Ekwall | Karolinska Institute |
| Gary Felsenfeld | NIH |
| Marco Foiani | University of Milan |
| Joost Gribnau | Erasmus University |
| Martin Hetzer | Salk Institute |
| Steve Jacobsen | UCLA |
| Mike McManus | UCSF |
| Kathrin Muegge | NIH |
| Philipp Oberdoerffer | NIH |
| Barbara Panning | UCSF |
| Brendan Price | Harvard |
| Haico van Attikum | Leiden University |
| Rick Young | Whitehead Institute and MIT |
| Daniel Zilberman | UC-Berkeley |
Upcoming Seminars of Interest
| Date | Speaker | Time/Location |
|---|---|---|
| 1/14/2015 | Melanie Ehrlich/ Tulane University | Bldg 50, noon |
| 2/4/2015 | Peggy Farnham/ USC | Bldg 37, noon |
| 2/12/2015 | David Sherrat/ Oxford | Bldg 37/ 6th floor, noon |
Workshop on Chromosome Biology
June 10, 2015
This Workshop is sponsored by the NCI's Center of Excellence in Chromosome Biology (CECB) and the NIH Chromatin Interest Group. The aim is to foster interaction among major laboratories in the areas of chromosome biology, and to enhance the education and development of junior investigators and fellows in CECB laboratories. With rapid advances and new technologies in the field, continuous interaction with members of the international community is critical to insure the most effective development of our research programs.
Keynote Presentation: Rodney Rothstein
Location: TBD
