Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. Its goals are a comprehensive understanding of the mechanisms involved in chromosome function, and the correction of aberrations in these processes that lead to disease.
The Center of Excellence in Chromosome Biology (CECB), open to all NCI intramural investigators, brings together experts from fields such as dynamics of chromatin structure and function; epigenetics and gene expression; chromosome segregation and cell division; DNA replication, repair, and recombination; chromosome organization and gene localization; and nuclear protein interaction dynamics. The CECB integrates the intellectual and physical resources within NCI's Intramural Research Program to support outstanding research in chromosome biology. Download our brochure
Objectives
- Promote interaction and collaboration among researchers within the NCI, NIH, and beyond
- Promote advances and opportunities for research in chromosome biology
- Leverage cutting-edge tools, approaches, and resources to advance chromosome biology as it applies to cancer research
- Train young investigators to address complex scientific questions through collaboration and multi-disciplinary approaches
CECB in the Press
NIH scientists visualize how cancer chromosome abnormalities form in living cells NCI press release
CECB: Capturing Dynamic Changes in Chromatin Connections vol 7 no 1
Upcoming Seminars of Interest
CECB Seminar Series
All lectures are in Bldg 50 1st floor conf room from 12-1PM
Workshop on Chromosome Biology
Wednesday March 12, 2014, 9AM to 12:00PM
This Workshop is sponsored by the NCI's Center of Excellence in Chromosome Biology (CECB) and the NIH Chromatin Interest Group. The aim is to foster interaction among major laboratories in the areas of chromosome biology, and to enhance the education and development of junior investigators and fellows in CECB laboratories. With rapid advances and new technologies in the field, continuous interaction with members of the international community is critical to insure the most effective development of our research programs.
Keynote Presentation: "Title to be announced"
Ramin Shiekhattar, PhD
?Professor, Gene Expression and Regulation Program
The Wistar Institute
Philadelphia PA?
The laboratory of Ramin Shiekhattar investigates the molecular mechanisms that underlie both cancer and gene regulation. In particular, the Shiekhattar laboratory explores how protein-coding genes are silenced and how disruption of gene silencing may lead to cancer. His work in the mechanics of gene regulation has led to his laboratory’s efforts in the field of epigenetics, the study of how certain molecules can change gene expression without changing the underlying DNA. In 2010, Shiekhattar published the discovery of long non-coding RNA, which his findings suggest may represent so-called gene enhancer elements—short regions of DNA that can increase gene transcription.
Postdoc speakers:
"A long non-coding RNA is required for CENP-A recruitment to the human centromere."
Delphine Quenet
Laboratory of Receptor Biology and Gene Expression (Yamini Dalal Lab), CCR, NCI
“Breaking the Dimer: Live Cell Imaging Unveils Multiple Domain Requirements for in vivo Dimerization of the Glucocorticoid Receptor”
Diego Presman
Laboratory of Receptor Biology and Gene Expression (Gordon Hager Lab), CCR, NCI
“Novel Nuclear RNA Processing Machinery and Heterochromatin Assembly in S. pombe”
Nathan Lee
Laboratory of Biochemistry and Molecular Biology (Shiv Grewal Lab), CCR, NCI
“miR-215 acts downstream of CDX1 to promote differentiation and limit self-renewal in colorectal cancer stem cells”
Matthew Jones
Genetics Branch (Ashish Lal Lab), CCR, NCI
