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Center For Cancer Research National Cancer Institute
Structural Biophysics Laboratory

Yun-Xing Wang, PhD
Head, PNAI Section
Building 538, Room 120
Frederick, MD 27102-1201

Phone: 301.846.5985
Fax: 301.846.6231

Protein-Nucleic Acid Interactions (PNAI) Section

My group’s long term research interest is to study structural biology of molecules involved in translational and post-translational processes related to cancer biology, using solution NMR spectroscopy and other biophysical methods. We also leverage the unique environment and resource available within CCR and collaborate extensively with other laboratories to apply multi-disciplinary approaches to understand fundamental biology on the both atomic and cellular levels. Our current focuses are in two areas: 1). 3’ untranslated regions (3’UTR) of mRNAs important for translation initiation; 2) the post-translational events involving chaperones and receptors in the Wnt/ß-catenin signaling pathway, and with the current emphasis placed on structural biology study of the 3’UTR RNA.

For the past 10-5 years, there has been a major expansion of our knowledge and understanding of roles RNA played in biology. In order to better understand the biological roles of RNA, we initiated a project to study the structural biology of large RNA molecules that are functionally relevant. Currently we are developing a new approach to derive global architecture of large RNA solution structures using NMR spectroscopy and small-angle X-ray scattering.

Experimental Approach
  1. Solution NMR spectroscopy
  2. Solution neutron and X-ray scattering
  3. Other biophysical methods
Research Projects
  1. The 3P program
  2. The dynamics and structure of ribosome protein L11
  3. Structural biology study of the receptor-associated protein, RAP
  4. Determining global architectures of complex without inter-subunit distance restraints
  5. A combined approach for determining large RNA structures in solution