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Center For Cancer Research National Cancer Institute
Structural Biophysics Laboratory

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Welcome!

The Structural Biophysics Laboratory (SBL) is a multi-disciplinary laboratory that strives to understand the function and mechanism of action of proteins and nucleic acids in the biological processes associated with cancer biology. Currently, the main structural technique is nuclear magnetic resonance (NMR) spectroscopy, and the groups are also active in the use of small angle scattering methods (SAXS and SANS) and surface plasmon resonance (SPR). The groups are engaged in both advancing the state-of-the-art methodology in these areas and applying them in an integrated cooperation with biologists within the CCR.

Please browse through this Web site to learn more about us and our research programs!

Macromolecular NMR Section

The general goals and projects of the lab deal with the structural biology of proteins involved in signal transduction and regulation of gene expression. Our research focuses on the elucidation of three-dimensional (3D) solution structure and dynamics of proteins and complexes. Read more...

Protein-Nucleic Acid Interactions Section

The general research interests of our group are to determine the structure of biological molecules, including nucleic acids, enzymes, RNA(DNA) protein complexes and clinically important enzyme drug complexes, using NMR and various other biophysical and biochemical methods. Read more...

Biophysics Resource

The Biophysics Resource (BR) is operated by the SBL. It is providing access to analytical instrumentation and any required assistance for researchers from the Center for Cancer Research in need of biophysical characterization and examination of systems subject to structural investigations. Read more...