If you have determined you have a good target and a good compound
There are three different options:
1) Proposal not supported by DDC- Committee felt proposal failed to demonstrate agent as good target and/or good compound.
2) More work needed- Committee felt more experiments were needed to determine if agent was as good target and/or good compound. Investigators are encouraged to perform the additional experiments and then come back to the DDC to present findings. The committee will re-review proposal and vote again.
3) Approved/Submit to NExT- Committee felt agent merits approval and is ready to be submitted to the NExT. Proposal will go to either the NCI Early Drug Discovery Committee or the NCI Drug Development Committee.