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Center for Cancer Research National Cancer Institute
Molecular Targets Laboratory

Publications of MTL Scientists, 2002-2017

2017

  1. Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz MA, Beutler JA. Growth inhibition of colon cancer and melanoma cells by versiol derivatives from a Paraconiothyrium sp. J Nat Prod, in press, 2017.

  2. da Cunha MG, Ramos-Junior ES, Franchin M, Taira TM, Beutler JA, Franco GCN, Ikegaki M, de Alencar SM, Fukuda SY, Rosalen PL. Effects of cinnamoyloxy-mammeisin from geopropolis on osteoclast differentiation and Porphyromonas gingivalis-induced periodontitis. J Nat Prod 80: 1893-1899, 2017. PubMed link

  3. Elliott DC, Beutler JA, Parker KA. The importance of a 4-alkyl substituent for activity in the englerin series. ACS Med Chem Lett, in press, 2017.

  4. Mitchell CA, Ramessar K, O'Keefe BR. Antiviral lectins: Selective inhibitors of viral entry. Antiviral Res 142: 37-54, 2017. PubMed link

  5. Wu Z, Zhao S, Fash DM, Li Z, Chain WJ, Beutler J. Englerins: A comprehensive review. J Nat Prod 80: 771-781, 2017. PubMed link

  6. Xu YM, Brooks AD, Wijeratne EM, Henrich CJ, Tewary P, Sayers TJ, Gunatilaka AA. 17beta-Hydroxywithanolides as sensitizers of renal carcinoma cells to tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL) mediated apoptosis: Structure-activity relationships. J Med Chem 60: 3039-3051, 2017. PubMed link

  7. Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS, Jr. Macrophilone A: Structure elucidation, total synthesis, and functional evaluation of a biologically active iminoquinone from the marine hydroid Macrorhynchia philippina. Org Lett 19: 1726-1729, 2017. PubMed link

2016

  1. V. Caropreso, E. Darvishi, T.J. Turbyville, R. Ratnayake, P.J. Grohar, J.B. McMahon, G. Woldemichael, Englerin A inhibits EWS-FLI1 DNA binding in Ewings sarcoma cells, J Biol Chem, 291: 10058-10066, 2016. PubMed link

  2. C.H. Chau, B.R. O'Keefe, W.D. Figg, The canSAR data hub for drug discovery, The Lancet Oncology, 17, 286, 2016. PubMed link

  3. N. Cho, E. Moon, H. Kim, J. Hong, J.A. Beutler, S.H. Sung, Inhibition of nitric oxide production in BV2 microglia cells by constituents of Tetrapanax papyriferus, Molecules, 21: 459, 2016. PubMed link

  4. N. Cho, H.W. Kim, T.T. Ransom, E. Smith, J.A. Beutler, S.H. Sung, Preparative isolation and purification of antiproliferative diarylheptanoids from Betula platyphylla by high speed counter-current chromatography, Molecules, 21: 700, 2016.  PubMed link

  5. M.G. da Cunha, G.C.N. Franco, M. Franchin, J.A. Beutler, S.M. de Alencar, M. Ikegaki, P.L. Rosalen, Prediction of pharmacokinetic and toxicological parameters of a 4-phenyl coumarin isolated from geopropolis: In silico and in vitro approaches. Tox. Lett., 263: 6-10, 2016. PubMed link

  6. M.G. da Cunha, M. Franchin, L.F. de Paula-Eduardo, I.A. Freires, J.A. Beutler, S.M. de Alencar, M. Ikegaki, C.P.M. Tabchoury, T.M. Cunha, P.L. Rosalen, Anti-inflammatory and anti-biofilm properties of ent-nemorosone from Brazilian geopropolis. J.Functional Foods 26: 27-35, 2016.

  7. E. Darvishi, G. Woldemichael, Cycloheximide inhibits actin cytoskeletal dynamics by suppressing signalling via RhoA, J Cell Biochem,, 117(12): 2886-2898, 2016. PubMed link

  8.  M. D'erasmo, T. Masaoka, J.A. Wilson, E.M. Hunte, Jr., J.A. Beutler, S.F.J. Le Grice, R.P. Murelli, Traceless solid-phase alpha-hydroxytropolone synthesis. MedChemComm 7: 1789-1792, 2016.

  9.  V. Fako, Z.. Yu, C.J. Henrich, T. Ransom, A.S. Budhu, X.W. Wang, Inhibition of wnt/beta-catenin signaling in hepatocellular carcinoma by an antipsychotic drug pimozide. Int J Biol Sci 12: 768-775, 2016. PubMed link

  10. D.M. Fash, C.J. Peer, Z. Li, I.J. Talisman, S. Hayavi, J.W. Ramos, W.D. Figg, J.A. Beutler, W.J. Chain, Synthesis of a stable and orally bioavailable englerin analogue, Bioorg.Med.Chem.Lett.,26: 2641-2644, 2016. PubMed link

  11. M. Franchin, P.L. Rosalen, M.G. da Cunha, R. Silva, D. Colon, G. Bassi, S.M. Alencar, M. Ikegaki, J. Alves-Filho, F. Cunha, J.A. Beutler, T. Cunha, The anti-inflammatory activity of cinnamoyloxy-mammesin, a 4-phenylcoumarin derivative isolated from geopropolis obtained from Melipona scutellaris, depends on inhibition of MAP kinases. J Nat Prod, 79: 1828-1833, 2016. PubMed link

  12. A.K. Goey, C.H. Chau, T.M. Sissung, K.M. Cook, D.J. Venzon, A. Castro, T.R. Ransom, C.J. Henrich, T.C. McKee, J.B. McMahon, T. Grkovic, M.M. Cadelis, B.R. Copp, K.R. Gustafson, W.D. Figg, Screening and biological effects of marine pyrroloiminoquinone alkaloids: Potential inhibitors of the HIF-1alpha/p300 interaction, J Nat Prod, 79(5): 1267-1275, 2016. PubMed link

  13.  C.J. Henrich, A microplate-based nonradioactive protein synthesis assay: Application to trail sensitization by protein synthesis inhibitors. PLoS One 11: e0165192, 2016. PubMed link

  14.  L. López-Suárez, F. Bravo, L. Riesgo, T. T. Ransom, J. A. Beutler, and A. M. Echavarren. Synthesis and biological evaluation of new (-)-englerin analogues. Chem Med Chem, 11: 1003-1007, 2016. PubMed link

  15. T. Masaoka, H. Zhao, D. R. Hirsch, M. P. D'Erasmo, C. Meck, B. Vardano, M. J. Meyers, J. Baines, J. A. Beutler, R. P. Murelli, L. Tang, S. F. J. Le Grice, Characterization of the C-terminal nuclease domain of herpes simplex virus pUL15 as a target of nucleotidyltransferase inhibitors. Biochemistry, 55: 809-819, 2016. PubMed link

  16. R.P. Murelli, M.P. d'Erasmo, D.R. Hirsch, C. Meck, T. Masaoka, J.A. Wilson, B. Zhang, R.K. Pal, E. Galicchio, J.A. Beutler, S.F.J. Le Grice,,  Synthetic alpha-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity. MedChemComm 7: 1783-1788, 2016.

  17. C. L. Osgood, N. Maloney, C. G. Kidd, S. M. Kitchen-Goosen, L. E. Segars, M. Gebregiorgis, G. M. Woldemichael, M. He, S. Sankar, S. L. Lessnick, M. H. Kang, M. A. Smith, L. Turner, Z. B. Madaj, M. E. Winn, L. E. Nunez, J. Gonzalez-Sabin, L. J. Helman, F. Moris, P. J. Grohar, Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor. Clin.Cancer Res., 22 (16): 4105-4118, 2016. PubMed link

  18. T. Schmid, J.S. Blees, M.M. Bajer, J. Wild, L. Pescatori, L.C. Crucitti, L. Scipione, R. Costi, C.J. Henrich, B. Brüne, N.H. Colburn, R. Di Santo, Diaryl sulfides as novel stabilizers of tumor suppressor Pdcd4, PLoS One, 11 (2016) e0151643. PubMed link

  19. E. Vamvaka, E. Arcalis, K. Ramessar, A. Evans, B. R. O'Keefe, R. J. Shattock, V. Medina, E. Stoger, P. Christou, T. Capell, Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV. Plant Biotechnol J, 14: 1427-1437, 2016. PubMed link

  20. E. Vamvaka, A. Evans, K. Ramessar, L.R. Krumpe, R.J. Shattock, B.R. O'Keefe, P. Christou, T. Capell, Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1 infection in vitro, Plant Cell Rep, 35: 1309-1319, 2016. PubMed link

  21. B. A. Wilson, M. S. Alam, T. Guszczynski, M. Jakob, S. R. Shenoy, C. A. Mitchell, E. I. Goncharova, J. R. Evans, P. Wipf, G. Liu, J. D. Ashwell, and B. R. O'Keefe. Discovery and characterization of a biologically active non-ATP-competitive p38 MAP kinase Inhibitor. J.Biomol.Screen. 21: 277-289, 2015. PubMed link

  22. B.W. Woodrum, J. Maxwell, D.M. Allen, J. Wilson, L.R. Krumpe, A.A. Bobkov, R.B. Hill, K.V. Kibler, B.R. O'Keefe, G. Ghirlanda, A designed "nested" dimer of cyanovirin-N increases antiviral activity, Viruses, 8 (2016). PubMed link

  23. D. Yeo, N. Huynh, J. A. Beutler, G. S. Baldwin, H. He, M. Nikfarjam, Glaucarubinone combined with gemcitabine improves pancreatic cancer survival in a immunocompetent orthotopic murine model. J.Invest.Surg. 30: 1-7, 2016. PubMed link

  24. W. Yuan, S. Cheng, W. Fu, M. Zhao, X. Li, Y. Cai, J. Dong, K. Huang, K. R. Gustafson, P. Yan, Structurally diverse metabolites from the soft coral Sinularia verruca collected in the South China Sea. J.Nat.Prod.,79: 1124-1131, 2016. PubMed link

  25. M. Zhao, S. Cheng, W. Yuan, Y. Xi, X. Li, J. Dong, K. Huang, K.R. Gustafson, P. Yan, Cembranoids from a Chinese collection of the soft coral Lobophytum crassum, Mar Drugs, 14 (2016). PubMed link

     

2015

  1. J.A. Beutler, Development of englerins for cancer therapy, Czech Chem.Soc.Symp.Ser., 13: 174-176, 2015.

  2. S. T. Chan, P. R. Patel, T. R. Ransom, C. J. Henrich, T. C. McKee, A. K. Goey, K. M. Cook, W. D. Figg, J. B. McMahon, M. J. Schnermann, and K. R. Gustafson. Structural elucidation and synthesis of eudistidine A: An unusual polycyclic marine alkaloid that blocks interaction of the protein binding domains of p300 and HIF-1alpha. J.Am.Chem.Soc. 137 (16):5569-5575, 2015.

    PubMed link

  3. A. Chatterjee, D. M. Ratner, C. M. Ryan, P. J. Johnson, B. R. O'Keefe, W. E. Secor, D. J. Anderson, P. W. Robbins, and J. Samuelson. Anti-retroviral lectins have modest effects on adherence of Trichomonas vaginalis to epithelial cells in vitro and on recovery of Tritrichomonas foetus in a mouse vaginal model. PLoS One 10 (8):e0135340, 2015. PubMed link

  4. M. G. da Cunha, S. M. de Alencar, M. Ikegaki, P. L. Rosalen, T. T. Ransom, and J. A. Beutler. Major constituents of Melipona scutellaris geopropolis and their antiproliferative activity. Planta Med.  82: 190-204, 2015.PubMed link

  5. G.C. Forcina, A., Castro, A., H.R. Bokesch, D.J. Spakowicz, M.E. Legaspi, K. Kucera, S. Villota, A. Narvaez-Trujillo, J.B. McMahon, K.R. Gustafson, S.A. Strobel, Stelliosphaerols A and B, sesquiterpene-polyol conjugates from an Ecuadorian fungal endophyte. J.Nat.Prod., 78: 3005-3010, 2015. PubMed link

  6. C. J. Henrich, A. D. Brooks, K. L. Erickson, C. L. Thomas, H. R. Bokesch, P. Tewary, C. R. Thompson, R. J. Pompei, K. R. Gustafson, J. B. McMahon, and T. J. Sayers. Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death.Dis. 6:e1666, 2015. PubMed link

  7. C. J. Henrich, L. K. Cartner, J. A. Wilson, R. W. Fuller, A. E. Rizzo, K. M. Reilly, J. B. McMahon, and K. R. Gustafson. Deguelins, natural product modulators of NF1-defective astrocytoma cell growth Identified by high-throughput screening of partially purified natural product extracts. J.Nat.Prod., 78: 2776-2781, 2015. PubMed link

  8. N. Huynj, J. A. Beutler, A. Shulkes, G. S. Baldwin, and H. He. Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway. Biochim.Biophys.Acta 1853:157-165, 2015. PubMed link
  9. Jakób, M., Lubkowski, J., O'Keefe, B. R., and Wlodawer, A. Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL). Acta Crystallograf., 71: 1429-1436, 2015. PubMed link

  10. M. K. P. Jayatunga, S. Thompson, T. C. McKee, M. C. Chan, K. M. Reece, A. P. Hardy, R. Sekirnik, P. T. Seden, K. M. Cook, J. B. McMahon, W. D. Figg, C. J. Schofield, and A. D. Hamilton. Inhibition of the HIF1alpha-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). Eur.J.Med.Chem. 94:509-516, 2015. PubMed link

  11. K. Levendosky, O. Mizenina, E. Martinelli, N. Jean-Pierre, L. Kizima, A. Rodriguez, K. Kleinbeck, T. Bonnaire, M. Robbiani, T. M. Zydowsky, B. R. O'Keefe, and J. A. Fernandez-Romero. Griffithsin and carrageenan combination to target HSV-2 and HPV. Antimicrob.Agents Chemother., 59: 7290-7298, 2015.  PubMed link

  12. J. Ma, R. S. Pawar, E. Grundel, E. P. Mazzola, C. D. Ridge, T. Masaoka, S. F. J. Le Grice, J. A. Wilson, J. A. Beutler, and A. J. Krynitsky. Sesquiterpenoid tropolone glycosides from Liriosma ovata. J.Nat.Prod. 78 (2):315-319, 2015. PubMed link

  13. T. Moulaei, K. B. Alexandre, S. R. Shenoy, J. Meyerson, L. R. Krumpe, B. Constantine, J. Wilson, R. Buckheit, J. B. McMahon, S. Subramaniam, A. Wlodawer, and O. Keefe BR. Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Retrovirology 12 (1):6, 2015. PubMed link

  14. B. R. O'Keefe, A. M. Murad, G. R. Vianna, K. Ramessar, C. J. Saucedo, J. Wilson, K. W. Buckheit, N. B. da Cunha, A. C. Araujo, C. C. Lacorte, L. Madeira, J. B. McMahon, and E. L. Rech. Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV. Plant Biotechnol.J. (7):884-892, 2015.  PubMed link

  15. E. V. Patridge, A. Darnell, K. Kucera, G. M. Phillips, H. R. Bokesch, K. R. Gustafson, D. J. Spakowicz, L. Zhou, W. M. Hungerford, M. Plummer, D. Hoyer, A. Narvaez-Trujillo, A. J. Phillips, S. A. Strobel, Pyrrolocin A, a 3-decalinoyltetramic acid with selective biological activity, isolated from Amazonian cultures of the novel endophyte Diaporthales sp. E6927E. Nat.Prod.Comm. 10: 1649-1654, 2015. PubMed link

  16. T. Qin, J. A. Beutler, and J. A. Porco, Jr. Synthesis of dimeric tetrahydroxanthones with varied linkages: Investigation of shapeshifting properties. J.Am.Chem.Soc. 137(48): 15225-15233, 2015. PubMed link

  17. H. J. Shin, M. A. Rashid, L. K. Cartner, H. R. Bokesch, J. A. Wilson, J. B. McMahon, and K. R. Gustafson. Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp. Tetrahedron Lett. 56 (28):4215-4219, 2015. PubMed link

  18. C. Sourbier, B. Scroggins, P. Z. Mannes, P. J. Liao, K. Siems, D. Wolf, J. A. Beutler, W. M. Linehan, and L. Neckers. Tonantzitlolone cytotoxicity toward renal cancer cells is PKCtheta- and HSF1-dependent.  Oncotarget, 6 (30): 29963-29974, 2015. PubMed link

  19. H. Zhao, Z. Lin, A. Y. Lynn, B. Vardano, J. A. Beutler, R. P. Murelli, S. F. J. Le Grice, and L. Tang. Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism. Nucl.Acids Res.43: 11003-11016, 2015. PubMed link

     

2014

  1. M. M. Bajer, M. M. Kunze, J. S. Blees, H. R. Bokesch, H. Chen, T. F. Brauss, Z. Dong, K. R. Gustafson, R. M. Biondi, C. J. Henrich, J. B. McMahon, N. H. Colburn, T. Schmid, and B. Brune. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem.Pharmacol. 88 (3): 313-321, 2014. PubMed link

  2. C. Barton, J. C. Kouokam, A. B. Lasnik, O. Foreman, A. Cambon, G. Brock, D. C. Montefiori, F. Vojdani, A. A. McCormick, B. R. O'Keefe, and K. E. Palmer. Activity and effect of subcutaneous treatment with the broad spectrum antiviral lectin griffithsin in two laboratory rodent models. Antimicrob.Agents Chemother. 58(1):120-127, 2014. PubMed link
  3. J. A. Beutler, G. M. Cragg, M. Iwu, D. J. Newman, and C. Okunji. Anticancer Potential of African Plants. The Experience of the United States National Cancer Institute and National Institutes of Health. Chapter 10 In: Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics, edited by A. Gurib-Fakim,Wiley-Blackwell, p.133-149, 2014.

  4. K. P. Devkota, J. A. Wilson, C. J. Henrich, J. B. McMahon, K. M. Reilly, and J. A. Beutler. Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells. Phytochem.Lett. 7 (1):42-45, 2014. PubMed link

  5. A. B. Dull, A. A. George, E. I. Goncharova, J. R. Evans, A. Wamiru, L. K. Cartner, G. L. Hager, and J. B. McMahon. Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor a chimera and exhibit agonist or antagonist activity in vitro. J.Biomol.Screen. 19 (2):242-252, 2014. PubMed link

  6. A. R. Garrison, B. G. Giomarelli, C. M. Lear-Rooney, C. J. Saucedo, S. Yellayi, L. R. Krumpe, M. Rose, J. Paragas, M. Bray, G. G. Olinger, Jr., J. B. McMahon, J. Huggins, and B. R. O'Keefe. The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus. Antiviral Res. 112: 1-7, 2014. PubMed link

  7. T. Grkovic, J. S. Blees, M. M. Bayer, N. H. Colburn, C. L. Thomas, C. J. Henrich, M. L. Peach, J. B. McMahon, T. Schmid, and K. R. Gustafson. Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4. Mar.Drugs 12 (8):4593-4601, 2014. PubMed link

  8. A. M. Hartung, J. A. Beutler, H. A. Navarro, D. F. Wiemer, and J. D. Neighbors. Stilbenes as kappa-selective non-nitrogenous opioid receptor antagonists. J.Nat.Prod. 77 (2): 311-319, 2014. PubMed link

  9. C. A. Hassig, F. Y. Zeng, P. Kung, M. Kiankarimi, S. Kim, P. W. Diaz, D. Zhai, K. Welsh, S. Morshedian, Y. Su, B. O'Keefe, D. J. Newman, Y. Rusman, H. Kaur, C. E. Salomon, S. G. Brown, B. Baire, A. R. Michel, T. R. Hoye, S. Francis, G. I. Georg, M. A. Walters, D. B. Divlianska, G. P. Roth, A. E. Wright, and J. C. Reed. Ultra-high-throughput screening of natural product extracts to identify proapoptotic inhibitors of bcl-2 family proteins. J.Biomol.Screen. 19 (8):1201-1211, 2014. PubMed link

  10. S. M. Jensen, F. W. Ruscetti, A. Rein, D. C. Bertolette, C. J. Saucedo, B. R. O'Keefe, and K. S. Jones. Differential inhibitory effects of cyanovirin-N, griffithsin and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses. J.Virol. 88 (4):2327-2332, 2014. PubMed link

  11. J. G. Kodet, J. A. Beutler, and D. F. Wiemer. Synthesis and structure activity relationships of schweinfurthin indoles. Bioorg.Med.Chem. 22 (8): 2542-2552, 2014. PubMed link

  12. S. J. Lockett, C. Cui, P. Gudla, K. Nandy, Y. Mimaki, P. L. Fuchs, J. Jaja, K. M. Reilly, J. A. Beutler, and T. J. Turbyville. Quantitative analysis of F-actin redistribution in astrocytoma cells treated with candidate pharmaceuticals. Cytometry A 85 (6):512-521, 2014.  PubMed link
  13. T. C. McKee, A. W. Van Wyk, and E. L. Whitson. Natural Product Screening. In: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, edited by W. D. Figg and H. L. McLeod, Totoawa, NJ: Humana Press, 2014, p. 39-67.

  14. S. Sunassee, T. T. Ransom, C. J. Henrich, J. A. Beutler, D. G. Covell, J. B. McMahon, and K. R. Gustafson. Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.  J.Nat.Prod. 77: 2475-2480, 2014. PubMed link

  15. J. Sztuba-Solinska, S. R. Shenoy, P. Gareiss, L. R. Krumpe, S. F. Le Grice, B. R. O'Keefe, and J. S. Schneekloth, Jr. Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays. J.Am.Chem.Soc., 136: 8402-8410, 2014. PubMed link

  16. D. Yeo, N. Huynh, J. A. Beutler, C. Christophi, A. Shulkes, G. S. Baldwin, M. Nikfarjam, and H. He. Glaucarubinone and gemcitibine synergistically reduce pancreatic cancer growth via inhibition of p21-activated kinases. Cancer Lett.  346 (2): 264-272, 2014. PubMed link

     

2013

  1. K. B. Alexandre, P. L. Moore, M. Nonyane, E. S. Gray, N. Ranchobe, E. Chakauya, J. B. McMahon, B. R. O'Keefe, R. Chikwamba, and L. Morris. Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN. Virology 446 (1-2):66-76, 2013. PubMed link

  2. J. A. Beutler. Natural Products as Tools for Discovering New Cancer Targets. In: Natural Products and Cancer Drug Discovery, edited by F. E. Koehn, New York: Humana Press, 2013, p. 213-237.

  3. K. P. Devkota, J. Wilson, C. J. Henrich, J. B. McMahon, K. M. Reilly, and J. A. Beutler. Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth. J.Nat.Prod. 76 (1):59-63, 2013. PubMed link

  4. K. P. Devkota, D. G. Covell, T. T. Ransom, J. B. McMahon, and J. A. Beutler. Growth inhibition of human colon carcinoma cells by sesquiterpenoids and tetralones of Zygogynum calothyrsum. J.Nat.Prod. 76 (4):710-714, 2013. PubMed link

  5. K. S. Dossou, K. P. Devkota, P. Kavanogh, J. Egan, J. A. Beutler, and R. Moaddel. Development and preliminary validation of a plate-based CB1/CB2 receptor functional assay. Anal.Biochem. 437 (2):137-143, 2013. PubMed link

  6. K. K. S. Dossou, K. P. Devkota, C. Morton, J. M. Egan, J. A. Beutler, and R. Moaddel. Identification of CB1/CB2 ligands from  Zanthoxylum bungeanum. J.Nat.Prod. 76 (11):2060-2064, 2013. PubMed link

  7. C. J. Henrich, A. Budhu, Z. Yu, J. R. Evans, E. I. Goncharova, T. T. Ransom, X. W. Wang, and J. B. McMahon. High-throughput screening for identification of inhibitors of EpCAM-dependent growth of hepatocellular carcinoma cells. Chem.Biol.Drug Des 82 (2):131-139, 2013. PubMed link

  8. C. J. Henrich and J. A. Beutler. Matching the power of high throughput screening to the chemical diversity of natural products. Nat.Prod.Repts. 30(10):1284-1298, 2013. PubMed link

  9. A. K. Kanduluru, P. Banerjee, J. A. Beutler, and P. L. Fuchs. A convergent total synthesis of the potent cephalostatin/ritterazine hybrid 25-epi ritterostatin GN1N. J.Org.Chem. 78 (18):9085-9092, 2013. PubMed link

  10. T. Masaoka, S. Chung, P. Carboni, J. A. Wilson, J. A. Beutler, G. Tocco, and S. F. J. Le Grice. Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.  J.Med.Chem. 56:5436-5445, 2013. PubMed link

  11. C. Sourbier, B. T. Scroggins, R. Ratnayake, T. L. Prince, S. Lee, J. M. Lee, J. B. Trepel, J. A. Beutler, W. M. Linehan, and L. M. Neckers. Englerin A stimulates PKC theta to inhibit insulin signaling while simultaneously activating HSF1: A case of pharmacologically induced synthetic lethality. Cancer Cell 23 (2):228-237, 2013. PubMed link    CCR news

  12. Y. Takebe, C. J. Saucedo, G. Lund, R. Uenishi, S. Hase, T. Tsuchiura, N. Kneteman, K. Ramessar, D. L. Tyrrell, M. Shirakura, T. Wakita, J. B. McMahon, and B. R. O'Keefe. Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus. PLoS One 8 (5):e64449, 2013. PubMed link

  13. D. K. Winter, Endoma-Arias-M.A., T. Hudlicky, J. A. Beutler, and J. A. Porco, Jr. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a simplified tetrahydroxanthone analogue.  J.Org.Chem. 78 (15):7617-7626, 2013. PubMed link

2012

  1. R. K. Akee, T. T. Ransom, R. Ratnayake, J. B. McMahon, and J. A. Beutler. Chlorinated englerins with selective inhibition of renal cancer cell growth. J.Nat.Prod. 75 (3): 459-463, 2012. PubMed link
  2. K. B. Alexandre, E. S. Gray, H. Mufhandu, J. B. McMahon, E. Chakauya, B. R. O'Keefe, R. Chikwamba, and L. Morris. The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells. Virology 423 (2):175-186, 2012. PubMed link
  3.  J. A. Beutler, G. M. Cragg, and D. J. Newman. The National Cancer Institute and Natural Product Based Drug Discovery in Africa. In: Drug Discovery in Africa, edited by K. Chibale, M. T. Davies-Coleman, and C. Masimirembwa,Springer, 2012, p. 29-51.

  4. J. S. Blees, H. R. Bokesch, D. Rubsamen, K. Schulz, L. Milke, M. M. Bajer, K. R. Gustafson, C. J. Henrich, J. B. McMahon, N. H. Colburn, T. Schmid, and B. Brune. Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase beta-TrCP1. PLoS One 7 (10):e46567, 2012. PubMed link
  5. T. Diyabalanage, R. Ratnayake, H. R. Bokesch, T. T. Ransom, C. J. Henrich, J. A. Beutler, J. B. McMahon, and K. R. Gustafson. Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera. J.Nat.Prod. 75 (8):1490-1494, 2012. PubMed link
  6. S. Dong, T. Qin, E. Hamel, J. A. Beutler, and J. A. Porco, Jr. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienonesand their biological evaluation. J.Am.Chem.Soc. 134 (48):19782-19787, 2012. PubMed link
  7. A. Giubellino, G. M. Woldemichael, C. Sourbier, M. J. Lizak, J. F. Powers, A. S. Tischler, and K. Pacak. Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging. Cancer Lett., 316: 46-52, 2012. PubMed Link
  8. T. Hatanaka, S. Ohzono, M. Park, K. Sakamoto, S. Tsukamoto, R. Sugita, H. Ishitobi, T. Mori, O. Ito, K. Sorajo, K. Sugimura, S. Ham, and Y. Ito. Human IgA-binding peptides selected from random peptide libraries: affinity maturation and application in IgA purification. J.Biol.Chem.  287 (51):43126-43136, 2012. PubMed link

  9. C. J. Henrich, C. L. Thomas, A. D. Brooks, N. L. Booth, E. M. Lowery, R. J. Pompei, J. B. McMahon, and T. J. Sayers. Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis. Apoptosis.17 (1):79-89, 2012. PubMed link
  10. T. C. McKee, D. Rabe, H. R. Bokesch, T. Grkovic, E. L. Whitson, T. Diyabalanage, A. W. Van Wyk, S. R. Marcum, R. S. Gardella, K. R. Gustafson, W. M. Linehan, J. B. McMahon, and D. P. Bottaro. Inhibition of hypoxia inducible factor-2 transcription: Isolation of active modulators from marine sponges. J.Nat.Prod. 75 (9):1632-1636, 2012. PubMed link
  11. T. X. Nguyen, A. Morrell, M. Conda-Sheridan, C. Marchand, K. Agama, A. Bermingham, A. G. Stephen, A. Chergui, A. Naumova, R. Fisher, B. R. O'Keefe, Y. Pommier, and M. Cushman. Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. J.Med.Chem. 55 (9):4457-4478, 2012. PubMed link
  12. E. L. Whitson, H. Sun, C. L. Thomas, C. J. Henrich, T. J. Sayers, J. B. McMahon, C. Griesinger, and T. C. McKee. Synergistic TRAIL Sensitizers from Barleria alluaudii and Diospyros maritima. J.Nat.Prod. 75 (3): 394-399, 2012. PubMed link
  13. G. M. Woldemichael, T. J. Turbyville, J. R. Vasselli, W. M. Linehan, and J. B. McMahon. Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A. Neoplasia. 14 (8):771-777, 2012. PubMed link

2011

  1. K. B. Alexandre, E. S. Gray, R. Pantophlet, P. L. Moore, J. B. McMahon, E. Chakauya, B. R. O'Keefe, R. Chikwamba, and L. Morris. Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site. J.Virol. 85 (17):9039-9050, 2011. PubMed link
  2. A. M. Best, J. Chang, A. B. Dull, J. A. Beutler, and E. D. Martinez. Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell based assay. J.Biomed.Biotechnol. Article ID 868095, 2011. PubMed link
  3. H. R. Bokesch, R. S. Gardella, D. C. Rabe, D. P. Bottaro, W. M. Linehan, J. B. McMahon, and T. C. McKee. A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum. Chem.Pharm.Bull. 59 (9):1178-1179, 2011. PubMed Link
  4. S. Chung, D. M. Himmel, J. K. Jiang, K. Wojtak, J. D. Baumann, J. W. Rausch, J. A. Wilson, J. A. Beutler, C. J. Thomas, E. Arnold, and S. F. J. Le Grice. Synthesis, activity, and structural analysis of novel a-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J.Med.Chem. 54 (13):4462-4473, 2011. PubMed link
  5. K. P. Devkota, R. Ratnayake, N. H. Colburn, J. A. Wilson, C. J. Henrich, J. B. McMahon, and J. A. Beutler. Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius. J.Nat.Prod. 74 (3):374-377, 2011. PubMed Link
  6. T. Diyabalanage, R. Ratnayake, C. J. Henrich, J. A. Beutler, N. H. Colburn, J. B. McMahon, and K. R. Gustafson. Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii. Bioorg.Med.Chem.Lett. 21 (15):4397-4399, 2011. PubMed link
  7. S. Dong, K. J. Cahill, M.-I. Kang, N. H. Colburn, C. J. Henrich, J. A. Wilson, J. A. Beutler, R. P. Johnson, and J. A. Porco, Jr. Microwave-assisted reaction screening: Tandem retro-Diels-Alder/Diels-Alder cycloadditions of ortho-quinol dimers. J.Org.Chem. 76 (21):8944-8954, 2011. PubMed link
  8. P. J. Grohar, G. M. Woldemichael, L. B. Griffin, A. Mendoza, Q. R. Chen, C. Yeung, D. G. Currier, S. Davis, C. Khanna, J. Khan, J. B. McMahon, and L. J. Helman. Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening. J.Natl.Cancer Inst. 103 (12):962-978, 2011. PubMed link
  9. T. Grkovic, J. S. Blees, N. H. Colburn, T. Schmid, C. L. Thomas, C. J. Henrich, J. B. McMahon, and K. R. Gustafson. Cryptocaryols A-H, alpha-Pyrone-Containing 1,3-Polyols from Cryptocarya sp. Implicated in Stabilizing the Tumor Suppressor Pdcd4. J.Nat.Prod. 74 (5):1015-1020, 2011.  PubMed Link
  10. T. Grkovic, E. L. Whitson, D. C. Rabe, R. S. Gardella, D. P. Bottaro, W. M. Linehan, J. B. McMahon, K. R. Gustafson, and T. C. McKee. Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2alpha induced gene expression. Bioorg.Med.Chem.Lett. 21 (7):2113-2115, 2011. PubMed link
  11. J. A. Kim, A. Wamiru, J. B. McMahon, S. F. J. Le Grice, J. A. Beutler, and Y. H. Kim. New monoterpene glycosides and phenolic compounds from Distylium racemosum, and their inhibitory activity against ribonuclease H. Bioorg.Med.Chem.Lett. 21 (10):2840-2844, 2011.PubMed link
  12. J. C. Kouokam, D. Huskens, D. Schols, A. Johannemann, S. K. Riedell, W. Walter, J. M. Walker, N. Matoba, B. R. O'Keefe, and K. E. Palmer. Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate. PLoS One 6 (8):e22635, 2011. PubMed link
  13. B. R. O'Keefe. Anti-HIV microbicide development: Targeting the virus is the key. Future Virol. 6 (5):553-556, 2011.
  14. W. L. Popplewell, R. Ratnayake, J. A. Wilson, J. A. Beutler, N. H. Colburn, C. J. Henrich, J. B. McMahon, and T. C. McKee. Grassypeptolides F and G, Cyanobacterial Peptides from Lyngbya majuscula. J.Nat.Prod. 74 (8):1686-1691, 2011. PubMed link
  15. L. Sando, S. Troeira Henriques, F. Foley, S. M. Simonsen, N. L. Daly, K. N. Hall, K. R. Gustafson, M. I. Aguilar, and D. J. Craik. A synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. Chembiochem. 12 (16):2456-2462, 2011. PubMed link
  16. D. L. Sloman, B. Mitsaev, S. S. Scully, J. A. Beutler, and J. A. Porco, Jr. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angew.Chem.Int.Ed.Engl.  50 (11): 2511-2515, 2011. PubMed link
  17. B. H. Tai, N. D. Nhut, N. X. Nhiem, T. H. Quang, N. T. T. Ngan, B. T. T. Luyen, T. T. Huong, J. Wilson, J. A. Beutler, N. K. Ban, N. M. Cuong, and Y. H. Kim. An evaluation of the RNase H inhibitory properties of Vietnamese medicinal plant extracts and natural compounds. Pharmaceutical Biol. 49 (10):1046-1051, 2011. PubMed Link
  18. J. J. Topczewski, M. P. Callahan, J. G. Kodet, J. D. Inbarasu, N. R. Mente, J. A. Beutler, and D. F. Wiemer. Relevance of the C-5 position to schweinfurthin induced cytotoxicity. Bioorg.Med.Chem. 19:7570-7581, 2011. PubMed link
  19. A. W. Van Wyk, K. M. Zuck, and T. C. McKee. Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum. J.Nat.Prod. 74 (5):1275-1280, 2011.  PubMed Link
  20. M. A. Versiani, T. Diyabalanage, R. Ratnayake, C. J. Henrich, S. E. Bates, J. B. McMahon, and K. R. Gustafson. Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2. J.Nat.Prod. 74 (2): 262-266, 2011. PubMed Link
  21. E. L. Whitson, K. M. Pluchino, M. D. Hall, J. B. McMahon, and T. C. McKee. New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth. Org.Lett. 13 (13):3518-3521, 2011.  PubMed link
  22. G. M. Woldemichael, T. J. Turbyville, W. M. Linehan, and J. B. McMahon. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 71 (1):134-142, 2011. PubMed link
  23. L. X. Zhao, S. X. Huang, S. K. Tang, C. L. Jiang, Y. Duan, J. A. Beutler, C. J. Henrich, T. Schmid, and B. Shen. Actinopolysporins A, B, C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora sp YIM90600. J.Nat.Prod. 74 (9):1990-1995, 2011. PubMed link

2010

  1. K. B. Alexandre, E. S. Gray, B. E. Lambson, P. L. Moore, I. A. Choge, K. Mlisana, S. S. Karim, J. McMahon, B. O'Keefe, R. Chikwamba, and L. Morris. Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin. Virology 402 (1):187-196, 2010. PubMed link
  2. J. S. Blees, T. Schmid, C. L. Thomas, A. R. Baker, L. Benson, J. R. Evans, E. I. Goncharova, N. H. Colburn, J. B. McMahon, and C. J. Henrich. Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4. J.Biomol.Screen. 15: 21-29, 2010. PubMed link
  3. H. R. Bokesch, L. K. Cartner, R. W. Fuller, J. A. Wilson, C. J. Henrich, J. A. Kelley, K. R. Gustafson, J. B. McMahon, and T. C. McKee. Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids. Bioorg.Med.Chem.Lett. 20:3848-3850, 2010. PubMed link
  4. G. G. Bushkin, D. M. Ratner, J. Cui, S. Banerjee, M. T. Duraisingh, C. V. Jennings, J. D. Dvorin, M. J. Gubbels, S. D. Robertson, M. Steffen, B. R. O'Keefe, P. W. Robbins, and J. Samuelson. Suggestive evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma. Eukaryot.Cell 9: 228-241, 2010. PubMed link
  5. A. Carpentieri, D. M. Ratner, S. K. Ghosh, S. Banerjee, G. G. Bushkin, J. Cui, M. Lubrano, M. Steffen, C. E. Costello, B. R. O'Keefe, P. W. Robbins, and J. Samuelson. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryotic Cell 9 (11):1661-1668, 2010. PubMed link
  6. S. Chung, M. Wendeler, J. W. Rausch, G. Beilhartz, M. Götte, B. R. O'Keefe, A. Bermingham, J. A. Beutler, S. Liu, X. Zhuang, and S. F. J. Le Grice. Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrob.Agents Chemother. 54 (9):3913-3921, 2010. PubMed link
  7. A. Dull, E. Goncharova, G. Hager, and J. B. McMahon. Development of an image analysis screen for estrogen receptor alpha (ERalpha) ligands through measurement of nuclear translocation dynamics. J.Steroid Biochem.Mol.Biol. 122 (5):341-351, 2010. PubMed link
  8. P. Klausmeyer, Q. N. Van, J. Jato, T. G. McCloud, and J. A. Beutler. Schweinfurthins I and J from Macaranga schweinfurthii. J.Nat.Prod. 73: 479-481, 2010. PubMed link
  9. T. Moulaei, S. R. Shenoy, B. Giomarelli, C. Thomas, J. B. McMahon, Z. Dauter, B. R. O'Keefe, and A. Wlodawer. Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure 18 (9):1104-1115, 2010. PubMed link
  10. T. Moulaei, O. Stuchlik, M. Reed, W. Yuan, J. Pohl, W. Lu, L. Haugh-Krumpe, B. R. O'Keefe, and A. Wlodawer. Topology of the disulfide bonds in the antiviral lectin scytovirin. Protein Sci. 19 (9):1649-1661, 2010. PubMed link
  11. B. R. O'Keefe, B. Giomarelli, D. L. Barnard, S. R. Shenoy, P. K. Chan, J. B. McMahon, K. E. Palmer, B. W. Barnett, D. K. Meyerholz, C. L. Wohlford-Lenane, and P. B. McCray, Jr. Broad spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol.  84: 2511-2521, 2010.  PubMed link
  12. N. Oku, K. Takada, R. W. Fuller, J. A. Wilson, M. L. Peach, L. K. Pannell, J. B. McMahon, and K. R. Gustafson. Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica. J.Am.Chem.Soc. 132 (30):10278-10285, 2010. PubMed link
  13. S. Suzuki, E. Urano, C. Hashimoto, H. Tsutsumi, T. Nakahara, T. Tanaka, Y. Nakanishi, K. Maddali, Y. Han, M. Hamatake, K. Miyauchi, Y. Pommier, J. A. Beutler, W. Sugiura, H. Fuji, T. Hoshino, K. Itotani, W. Nomura, T. Narumi, N. Yamamoto, J. A. Komano, and H. Tamamura. Peptide HIV-1 integrase inhibitors from HIV-1 gene products. J.Med.Chem. 53:5356-5360, 2010. PubMed link
  14. K. Takada, N. Imamura, K. R. Gustafson, and C. J. Henrich. Synthesis and structure-activity relationship of botryllamides that block the ABCG2 multidrug transporter. Bioorg.Med.Chem.Lett.  20: 1330-1333, 2010. PubMed link
  15. T. J. Turbyville, D. B. Gürsel, R. G. Tuskan, J. C. Walrath, C. Lipshutz, S. J. Lockett, D. F. Wiemer, J. A. Beutler, and K. M. Reilly. Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in an NF1-GRD dependent manner. Mol.Cancer Ther.  9: 1234-1243, 2010. PubMed link
  16. N. Ulrich, J. G. Kodet, N. R. Mente, C. H. Kuder, J. A. Beutler, R. J. Hohl, and D. F. Wiemer. Structural analogues of schweinfurthin F: Probing the steric, electronic and hydrophobic properties of the D-ring substructure. Bioorg.Med.Chem. 18: 1676-1683, 2010. PubMed link
  17. E. L. Whitson, C. L. Thomas, C. J. Henrich, T. J. Sayers, J. B. McMahon, and T. C. McKee. Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers. J.Nat.Prod. 73 (12):2013-2018, 2010. PubMed link

2009

  1. J. A. Beutler, M.-I. Kang, F. Robert, J. A. Clement, J. Pelletier, N. H. Colburn, T. C. McKee, E. Goncharova, J. B. McMahon, and C. J. Henrich. Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. J.Nat.Prod. 72(3): 503-506, 2009. PubMed link
  2. J. A. Beutler. Natural products as a foundation for drug discovery. Curr. Protocols Pharmacol. 46: 9.11.1-9.11.21, 2009. PubMed link
  3. N. L. Booth, T. J. Sayers, A. D. Brooks, C. F. Thomas, K. Jacobsen, E. I. Goncharova, J. B. McMahon and C. J. Henrich. A cell-based high-throughput screen to identify synergistic TRAIL sensitizers. Cancer Immunol.Immunother. 58 (8):1229-1244, 2009.  PubMed link
  4. G.M. Cragg, J.A. Beutler, W.P. Jones, eds. The American Society of Pharmacognosy. 50 Years of Progress in Natural Progress Research. 1959-2009, American Society of Pharmacognosy, 2009. 280 pages. Online publication
  5. C. Cui, J. Jaja, T. Turbyville, J. Beutler, P. Gudla, K. Nandy, and S. Lockett. Quantifying the astrocytoma cell response to candidate pharmaceutical from F-actin image analysis. Conf.Proc.IEEE Eng.Med.Biol.Soc. 2009:5768-5771, 2009. PubMed link
  6. S. Dong, E. Hamel, R. Bai, D. G. Covell, J. A. Beutler, and J. A. Porco, Jr. Enantioselective synthesis of (plus) -chamaecypanone C, a novel microtubule inhibitor. Angew.Chem.Int.Ed.Engl. 48 (8): 1494-1497, 2009. PubMed link
  7. C. J. Henrich, R. W. Robey, K. Takada, H. R. Bokesch, S. E. Bates, S. Shukla, S. V. Ambudkar, J. B. McMahon, and K. R. Gustafson. Botryllamides: natural product inhibitors of ABCG2. ACS Chem.Biol. 4 (8):637-647, 2009. PubMed link
  8. M. I. Kang, C. J. Henrich, H. R. Bokesch, K. R. Gustafson, J. B. McMahon, A. R. Baker, M. R. Young, and N. H. Colburn. A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits". Mol. Cancer Ther. 8 (3):571-581, 2009. PubMed link
  9. Y. Liu, J. R. Carroll, L. A. Holt, J. McMahon, B. Giomarelli, and G. Ghirlanda. Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin. Biopolymers 92 (3):194-200, 2009. PubMed link
  10. B. R. O'Keefe, F. Vojdani, V. Buffa, R. J. Shattock, D. C. Montefiori, J. Bakke, J. Mirsalis, A. L. d'Andrea, S. D. Hume, B. Bratcher, C. J. Saucedo, J. B. McMahon, G. P. Pogue, and K. E. Palmer. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proc.Natl.Acad.Sci U S A 106 (15):6099-6104, 2009. PubMed link
  11. R. Ratnayake, D. G. Covell, T. T. Ransom, K. R. Gustafson, and J. A. Beutler. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. Org.Lett. 11 (1):57-60, 2009. PubMed link
  12. M. Wendeler, G. L. Beilhartz, M. Götte, J. A. Beutler, and S. F. J. Le Grice. Human immunodeficiency virus ribonuclease H: Continuing the search for small molecule antagonists. HIV Therapy  3 (1):39-53, 2009. 
  13. I. E. Wrona, J. T. Lowe, T. J. Turbyville, T. R. Johnson, J. Beignet, J. A. Beutler, and J. S. Panek. Synthesis of a 35-member stereoisomer library of bistramide A: Evaluation of effects on actin state, cell cycle and tumor cell growth. J.Org.Chem. 74 (5): 1897-1916, 2009. PubMed link
  14. S. M. Yun, T. Moulaei, D. Lim, J. K. Bang, J. E. Park, S. R. Shenoy, F. Liu, Y. H. Kang, C. Liao, N. K. Soung, S. Lee, D. Y. Yoon, Y. Lim, D. H. Lee, A. Otaka, E. Appella, J. B. McMahon, M. C. Nicklaus, T. R. Burke, Jr., M. B. Yaffe, A. Wlodawer, and K. S. Lee. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct.Mol Biol. 16 (8):876-882, 2009. PubMed link

2008

  1. H. R. Bokesch, A. Wamiru, S. F. J. Le Grice, J. A. Beutler, T. C. McKee, and J. B. McMahon. New HIV-1 inhibitory ribonuclease H phenolic glycosides from Eugenia hiemalis. J.Nat.Prod. 71 (9):1634-1636, 2008. PubMed link
  2. J. A. Clement, J. Kitagaki, Y. Yang, C. J. Saucedo, B. R. O'Keefe, A. M. Weissman, T. C. McKee, and J. B. McMahon. Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. Bioorg.Med.Chem. 16 (23):10022-10028, 2008. PubMed link
  3. D. C. Ireland, C. K. Wang, J. A. Wilson, K. R. Gustafson, and D. J. Craik. Cyclotides as natural anti-HIV agents. Biopolymers 90 (1):51-60, 2008.PubMed link
  4. C. Marchand, J. A. Beutler, A. Wamiru, S. R. Budihas, U. Mollmann, L. Heinisch, J. W. Mellors, S. F. Le Grice, and Y. Pommier. Madurahydroxylactone derivatives as dual inhibitors of HIV-1 integrase and RNase H. Antimicrob.Agents Chemother. 52 (1):361-364, 2008. PubMed link
  5. A. M. Mayer and K. R. Gustafson. Marine pharmacology in 2005-2006: Antitumor and cytotoxic compounds. Eur.J.Cancer  44 (16):2357-2387, 2008. PubMed link
  6. C. A. Sasiela, D. H. Stewart, J. Kitagaki, Y. Safiran, Y. Yang, A. M. Weissman, P. Oberoi, I. Davydov, E. Goncharova, J. A. Beutler, B. R. O'Keefe, and J. B. McMahon. Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high throughput electrochemiluminescent screen. J.Biomol.Screen. 13 (3):229-237, 2008. PubMed link
  7. D. F. Smee, K. W. Bailey, M. H. Wong, B. R. O'Keefe, K. R. Gustafson, V. P. Mishin, and L. V. Gubareva. Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N. Antiviral Res. 80 (3):266-271, 2008. PubMed link
  8. C. K. Wang, M. L. Colgrave, K. R. Gustafson, D. C. Ireland, U. Goransson, and D. J. Craik. Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. J Nat Prod. 71 (1):47-52, 2008. PubMed link
  9. A. M. Weissman, Y. Yang, J. Kitagaki, C. A. Sasiela, J. A. Beutler, and B. R. O'Keefe. Inhibiting Hdm2 and ubiquitin-activating enzyme: Targeting the ubiquitin conjugating system in cancer. Ernst.Schering.Found.Symp.Proc. (1):171-190, 2008. PubMed link
  10. M. Wendeler, H.-F. Lee, A. Bermingham, J. T. Miller, O. Chertov, M. K. Bona, N. S. Baichoo, M. Ehteshami, J. A. Beutler, B. R. O'Keefe, M. Götte, M. Kvaratskhelia, and S. F. J. Le Grice. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.  ACS Chem.Biol. 3 (10):635-644, 2008. PubMed link

2007

  1. N. T. Dat, K. H. Bae, A. Wamiru, J. B. McMahon, S. F. J. Le Grice, M. Bona, J. A. Beutler, and Y. H. Kim. A dimeric lactone from Ardisia japonica which inhibits HIV-1 and HIV-2 ribonuclease H. J.Nat.Prod. 70 (5):839-841, 2007. PubMed link
  2. P. Emau, B. Tian, B. R. O'Keefe, T. Mori, J. B. McMahon, K. E. Palmer, Y. Jiang, G. Bekele, and C. C. Tsai. Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide. J Med Primatol. 36 (4-5):244-253, 2007. PubMed link
  3. R. Fromme, Z. Katilene, B. Giomarelli, F. Bogani, J. McMahon, T. Mori, P. Fromme, and G. Ghirlanda. A monovalent mutant of cyanovirin-N provides insight into the role of multiple interactions with gp120 for antiviral activity. Biochemistry 46:9199-9207, 2007. PubMed link
  4. B. Giomarelli, A. V. Washington, M. Chisholm, L. Quigley, J. B. McMahon, T. Mori, and D. W. McVicar. Inhibition of thrombin-induced platelet aggregation using human single chain Fv antibodies specific for TREM-like transcript-1. Thrombosis & Hemostasis 97 (6):955-963, 2007. PubMed link
  5. C. J. Henrich, E. I. Goncharova, J. A. Wilson, R. S. Gardella, T. R. Johnson, J. B. McMahon, K. Takada, H. R. Bokesch, and K. R. Gustafson. Natural products active in aberrant c-Kit signaling. Chemical Biology & Drug Design 69:321-330, 2007. PubMed link
  6. C. J. Henrich, R. W. Robey, H. R. Bokesch, S. E. Bates, S. Shukla, S. V. Ambudkar, M. Dean, and J. B. McMahon. New inhibitors of ABCG2 identified by high-throughput screening. Mol.Cancer Ther. 6 (12):3271-3278, 2007. PubMed link
  7. L. R. Krumpe, K. M. Schumacher, J. B. McMahon, L. Makowski, and T. Mori. Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library. BMC Biotechnol. 7:65, 2007. PubMed link
  8. R. L. McFeeters, C. Xiong, B. R. O'Keefe, H. R. Bokesch, J. B. McMahon, D. M. Ratner, R. Castelli, P. H. Seeberger, and R. A. Byrd. The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors. J.Mol.Biol. 369 (2):451-461, 2007. PubMed link
  9. N. Mente, A. J. Wiemer, J. D. Neighbors, J. A. Beutler, R. J. Hohl, and D. F. Wiemer. Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series. Bioorg.Med.Chem.Lett. 17:911-915, 2007. PubMed link
  10. T. L. Meragelman, R. H. Willis, G. M. Woldemichael, A. Heaton, P. T. Murphy, K. M. Snader, D. J. Newman, R. V. Soest, M. R. Boyd, J. H. Ii, and T. C. McKee. Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia. J. Nat. Prod. 70 (7): 1133-1138, 2007. PubMed link
  11. T. Moulaei, I. Botos, N. E. Ziolkowska, H. R. Bokesch, L. R. Krumpe, T. C. McKee, B. R. O'Keefe, Z. Dauter, and A. Wlodawer. Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Sci. 16 (12):2756-2760, 2007. PubMed link
  12. K. M. Ruocco, E. I. Goncharova, M. R. Young, N. H. Colburn, J. B. McMahon, and C. J. Henrich. A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1. J Biomol.Screen.  12 (1):133-139, 2007. PubMed link
  13. D.F. Smee, M.K. Wandersee, M.B. Checketts, B.R. O'Keefe, C. Saucedo, M.R. Boyd, V.P. Mishin, L.V. Gubareva. Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor. Antivir Chem Chemother.18(6):317-27, 2007. PubMed link

  14. K. Takada, A. Bermingham, B. R. O'Keefe, A. Wamiru, J. A. Beutler, S. F. J. Le Grice, J. Lloyd, K. R. Gustafson, and J. B. McMahon. A new HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis. J.Nat.Prod. 70 (10):1647-1649, 2007. PubMed link
  15. K. Takada, B. W. Choi, M. A. Rashid, W. R. Gamble, J. H. Cardellina, Q. N. Van, J. R. Lloyd, J. B. McMahon, and K. R. Gustafson. Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species. J Nat Prod. 70 (3):428-431, 2007. PubMed link
  16. Y. Yang, J. Kitagaki, R. M. Dai, Y. C. Tsai, K. L. Lorick, R. L. Ludwig, S. A. Pierre, J. P. Jensen, I. V. Davydov, P. Oberoi, C.-C. Li, J. H. Kenten, J. A. Beutler, K. H. Vousden, and A. M. Weissman. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res. 67 (19):9472-9481, 2007. PubMed link
  17. N. E. Ziolkowska, S. R. Shenoy, B. R. O'Keefe, and A. Wlodawer. Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine. Protein Sci. 16 (7):1485-1489, 2007. PubMed link
  18. N. E. Ziolkowska, S. R. Shenoy, B. R. O'Keefe, J. B. McMahon, K. E. Palmer, R. A. Dwek, M. R. Wormald, and A. Wlodawer. Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins 67 (3):661-670, 2007. PubMed link

2006

  1. J. A. Beutler, J. Jato, G. M. Cragg, D. F. Wiemer, J. D. Neighbors, M. S. Salnikova, M. G. Hollingshead, D. Scudiero, and T. G. McCloud. The schweinfurthins: Issues in development of a plant-based anticancer lead. In:  Medicinal and Aromatic Plants.  Agricultural, Commercial, Ecological, Legal, Pharmacological and Social Aspects, edited by R. J. Bogers, L. Craker, and D. Lange, Dordrecht, The Netherlands:Springer, 2006, p. 301-309.
  2. B. Giomarelli, K. M. Schumacher, T. E. Taylor, R. C. Sowder, J. L. Hartley, J. B. McMahon, and T. Mori. Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture. Protein Expr.Purif. 47 (1):194-202, 2006. PubMed link
  3. F. Helle, C. Wychowski, N. Vu-Dac, K. R. Gustafson, C. Voisset, and J. Dubuisson. Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans. J.Biol.Chem. 281 (35):25177-25183, 2006.
  4. C. J. Henrich, H. R. Bokesch, M. Dean, S. E. Bates, R. W. Robey, E. I. Goncharova, J. A. Wilson, and J. B. McMahon. A high-throughput cell-based assay for inhibitors of ABCG2 activity. J.Biomol.Screen. 11:176-183, 2006. PubMed link
  5. Y. H. Kim, E. J. Park, M. H. Park, U. Badarch, G. Woldemichael, and J. A. Beutler. Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2. Biol.Pharm.Bull. 29 (10):2140-2142, 2006. PubMed link
  6. L. R. Krumpe, A. J. Atkinson, G. W. Smythers, A. Kandel, K. M. Schumacher, J. B. McMahon, L. Makowski, and T. Mori. T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries. Proteomics. 6 (15):4210-4222, 2006. PubMed link
  7. L. R. Krumpe and T. Mori. The use of phage-displayed peptide libraries to develop tumor-targeting drugs. Int.J.Peptide Res.Therapeut. 12:79-91, 2006.
  8. M. C. Liang, S. Bardhan, E. A. Pace, D. Rosman, J. A. Beutler, J. A. Porco, Jr., and T. D. Gilmore. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity. Biochem.Pharmacol. 71 (5):634-645, 2006. PubMed link
  9. E. D. Martinez, A. B. Dull, J. A. Beutler, and G. L. Hager. High content fluorescence-based screening for epigenetic modulators. Methods Enzymol. 414:21-36, 2006. PubMed link
  10. A. M. Mayer and K. R. Gustafson. Marine pharmacology in 2003-2004: anti-tumour and cytotoxic compounds. Eur.J Cancer 42 (14):2241-2270, 2006. PubMed link
  11. J. D. Neighbors, M. S. Salnikova, J. A. Beutler, and D. F. Wiemer. Synthesis and structure activity studies of schweinfurthin B analogs:  Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity. Bioorg.Med Chem. 14:1771-1784, 2006. PubMed link
  12. G. M. Woldemichael, J. R. Vasselli, R. S. Gardella, T. C. McKee, W. M. Linehan, and J. B. McMahon. Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression. J.Biomol.Screen. 11 (6):678-687, 2006. PubMed link
  13. C. Xiong, B. R. O'Keefe, I. Botos, A. Wlodawer, and J. B. McMahon. Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expr.Purif. 46 (2):233-239, 2006.PubMed link
  14. C. Xiong, B. R. O'Keefe, R. A. Byrd, and J. B. McMahon. Potent anti-HIV activity of scytovirin domain 1 peptide. Peptides 27 (7):1668-1675, 2006. PubMed link
  15. N. E. Ziolkowska, B. R. O'Keefe, T. Mori, C. Zhu, B. Giomarelli, F. Vojdani, K. E. Palmer, J. B. McMahon, and A. Wlodawer. Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure 14 (7):1127-1135, 2006. PubMed link

2005

  1. S. R. Budihas, I. I. Gorshkova, S. A. Gaidamakov, A. Wamiru, M. K. Bona, M. A. Parniak, R. C. Crouch, J. B. McMahon, J. A. Beutler, and S. F. J. Le Grice. Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Nucl.Acids Res. 33 (4):1249-1256, 2005. PubMed link
  2. I. Calis, H. Kirmizibekmez, J. A. Beutler, A. A. Dönmez, F. N. Yalcin, E. Kilic, M. Özalp, P. Rüedi, and D. Tasdemir. Secondary metabolites of Phlomis viscosa and their biological activities. Turkish J.Chem. 29 (1):71-81, 2005. 
  3. B. Chen, M. L. Colgrave, N. L. Daly, K. J. Rosengren, K. R. Gustafson, and D. J. Craik. Isolation and characterization of novel cyclotides from Viola hederaceae: Solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide. J.Biol.Chem.  280 (23):22395-22405, 2005. PubMed link
  4. M. G. Dijoux, P. C. Schnabel, Y. F. Hallock, J. L. Boswell, T. R. Johnson, J. A. Wilson, C. M. Ireland, R. W. M. Van Soest, M. R. Boyd, L. R. Barrows, and J. H. Cardellina, II. Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya. Bioorg.Med.Chem. 13:6035-6044, 2005. PubMed link
  5. A. Koltay, N. L. Daly, K. R. Gustafson, and D. J. Craik. Structure of circulin B and implications for antimicrobial activity of the cyclotides. Int.J.Peptide Res.Therapeut. 11:51-58, 2005. 
  6. E. D. Martinez, G. V. Rayasam, A. B. Dull, D. A. Walker, and G. L. Hager. An estrogen receptor chimera senses ligands by nuclear translocation. J.Steroid Biochem.Mol.Biol. 97 (4):307-321, 2005. PubMed link
  7. J. B. McMahon, K. R. Gustafson, and C. J. Henrich. Molecular-targeted drug screening at the NCI Center for Cancer Research. AACR Education Book.  125-129, 2005.
  8. T. Mori, B. R. O'Keefe, R. C. Sowder, S. Bringans, R. Gardella, S. Berg, P. Cochran, J. A. Turpin, R. W. Buckheit, Jr., J. B. McMahon, and M. R. Boyd. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. J.Biol.Chem. 280 (10):9345-9353, 2005. PubMed link
  9. J. D. Neighbors, J. A. Beutler, and D. F. Wiemer. Synthesis of nonracemic 3-deoxyschweinfurthin B. J.Org.Chem. 70 (3):925-931, 2005. PubMed link
  10. D. F. Nellis, S. L. Giardina, G. M. Janini, S. R. Shenoy, J. D. Marks, R. Tsai, D. C. Drummond, K. Hong, J. W. Park, T. F. Ouellette, S. C. Perkins, and D. B. Kirpotin. Preclinical manufacture of anti-HER2 liposome-inserting, scFv-PEG-lipid conjugate. 2. Conjugate micelle identity, purity, stability, and potency analysis. Biotechnol.Prog. 21 (1):221-232, 2005. PubMed link
  11. Newman, D. J.; Cragg, G. M. and O'Keefe, B. R.:  Biopharmaceutical drugs from natural sources. Part II, Chapter 4, p.451-496. Modern Biopharmaceuticals: Design, Development and Optimization.  J. Knablein, Ed., Wiley-VCH Verlag GmbH & Col., 2005.
  12. N. Oku, R. Krishnamoorthy, A. G. Benson, R. L. Ferguson, M. A. Lipton, L. R. Phillips, K. R. Gustafson, and J. B. McMahon. Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B. J.Org.Chem. 70 (17):6842-6847, 2005. PubMed link
  13. M. Witvrouw, V. Fikkert, A. Hantson, C. Pannecouque, B. R. O'Keefe, J. McMahon, L. Stamatatos, E. De Clercq, and A. Bolmstedt. Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. J.Virol. 79 (12):7777-7784, 2005. PubMed link

2004

  1. E. W. Adams, D. M. Ratner, H. R. Bokesch, J. B. McMahon, B. R. O'Keefe, and P. H. Seeberger. Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions. Chem.Biol. 11 (6):875-881, 2004. PubMed link
  2. D. G. Barry, N. L. Daly, H. R. Bokesch, K. R. Gustafson, and D. J. Craik. Solution structure of the cyclotide palicourein: Implications for the development of a pharmaceutical framework. Structure 12 (1):85-94, 2004. PubMed link
  3. H. R. Bokesch, R. D. Charan, K. M. Meragelman, R. S. Gardella, J. A. Beutler, B. R. O'Keefe, T. C. McKee, and J. B. McMahon. Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea. FEBS Lett. 567:287-290, 2004. PubMed link
  4. S. D. Bringans, B. R. O'Keefe, M. Bray, C. A. Whitehouse, and M. R. Boyd. Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma. Anal.Bioanal.Chem 380 (2):269-274, 2004. PubMed link
  5. K. C. Chan, S. R. Budihas, S. F. J. Le Grice, M. A. Parniak, R. J. Crouch, S. A. Gaidamakov, H. J. Isaaq, A. Wamiru, J. B. McMahon, and J. A. Beutler. A capillary electrophoretic assay for ribonuclease H activity. Anal.Biochem. 331 (2):296-302, 2004. PubMed link
  6. R. D. Charan, T. C. McKee, and M. R. Boyd. Cytotoxic alkaloids from the marine sponge Thorectandra sp. Nat.Prod.Res. 18 (3):225-229, 2004. PubMed link
  7. N. L. Daly, K. R. Gustafson, and D. J. Craik. The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1.  FEBS Lett. 574 (1-3):69-72, 2004.PubMed link
  8. K. R. Gustafson, T. C. McKee, and H. R. Bokesch. Anti-HIV cyclotides. Curr.Protein Pept.Sci. 5 (5):331-340, 2004. PubMed link
  9. Z. Han, J. T. Simpson, M. J. Fivash, R. Fisher, and T. Mori. Identification and characterization of peptides that bind to cyanovirin-N, a potent human immunodeficiency virus-inactivating protein. Peptides 25 (4):551-561, 2004. PubMed link
  10. S. Hess, K. R. Gustafson, D. J. Milanowski, E. Alvira, M. A. Lipton, and L. K. Pannell. Chirality determination of unusual amino acids using precolumn derivatization and liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr.A 1035 (2):211-219, 2004. PubMed link
  11. N. Lopanik, K. R. Gustafson, and N. Lindquist. Structure of bryostatin 20: A symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina. J.Nat.Prod. 67 (8):1412-1414, 2004.PubMed link
  12. A. M. Mayer and K. R. Gustafson. Marine pharmacology in 2001-2: antitumour and cytotoxic compounds. Eur.J Cancer 40 (18):2676-2704, 2004. PubMed link
  13. K. M. Meragelman, T. C. McKee, and J. B. McMahon. Monanchorin, a bicyclic alkaloid from the sponge Monanchora unguiculata. J.Nat.Prod. 67 (7):1165-1167, 2004. PubMed link
  14. D. J. Milanowski, K. R. Gustafson, J. A. Kelley, and J. B. McMahon. Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinolines from the marine bryozoan Caulibugula intermis. J.Nat.Prod. 67 (1):70-73, 2004. PubMed link
  15. D. J. Milanowski, M. A. Rashid, K. R. Gustafson, B. R. O'Keefe, J. P. Nawrocki, L. K. Pannell, and M. R. Boyd. Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri. J.Nat.Prod. 67 (3):441-444, 2004. PubMed link
  16. D. J. Milanowski, K. R. Gustafson, M. A. Rashid, L. K. Pannell, J. B. McMahon, and M. R. Boyd. Gymnangiamide, a cytotoxic pentapeptide from the marine hydroid Gymnangium regae. J.Org.Chem. 69 (9):3036-3042, 2004. PubMed link
  17. T. Mori. Cancer-specific ligands identified from screening of peptide-display libraries. Curr.Pharm Des 10 (19):2335-2343, 2004. PubMed link
  18. N. Oku, K. R. Gustafson, L. K. Cartner, J. A. Wilson, N. Shigematsu, S. Hess, L. K. Pannell, M. R. Boyd, and J. B. McMahon. Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi. J.Nat.Prod. 67 (8):1407-1411, 2004. PubMed link
  19. H. V. Pai, R. P. Kommaddi, S. J. Chinta, T. Mori, M. R. Boyd, and V. Ravindranath. A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. J.Biol.Chem. 279 (26):27383-27389, 2004. PubMed link
  20. D. M. Ratner, E. W. Adams, J. Su, B. R. O'Keefe, M. Mrksich, and P. H. Seeberger. Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides. Chembiochem. 5 (3):379-383, 2004. PubMed link
  21. C. C. Tsai, P. Emau, Y. H. Jiang, M. B. Agy, R. J. Shattock, A. Schmidt, W. R. Morton, K. R. Gustafson, and M. R. Boyd. Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models. AIDS Res.Hum.Retroviruses 20 (1):11-18, 2004. PubMed link

2003

  1. E. W. Adams, J. Ueberfeld, D. M. Ratner, B. R. O'Keefe, D. R. Walt, and P. H. Seeberger. Encoded fiber-optic microsphere arrays for probing protein-carbohydrate interactions. Angew.Chem.Int.Ed Engl. 42 (43):5317-5320, 2003. PubMed link
  2. L. G. Barrientos, B. R. O'Keefe, M. Bray, A. Sanchez, A. M. Gronenborn, and M. R. Boyd. Cyanovirin-N binds to the viral surface glycoprotein GP1,2 and inhibits infectivity of Ebola virus. Antiviral Res. 58:47-56, 2003. PubMed link
  3. J. A. Beutler and T. C. McKee. Novel marine and microbial natural product inhibitors of vacuolar ATPase. Curr.Med.Chem. 10 (9):787-796, 2003. PubMed link
  4. H. R. Bokesch, B. R. O'Keefe, T. C. McKee, L. K. Pannell, G. M. Patterson, R. S. Gardella, R. C. Sowder, J. Turpin, K. Watson, R. W. Buckheit, Jr., and M. R. Boyd. A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry 42 (9):2578-2584, 2003. PubMed link
  5. E. J. Bowman, K. R. Gustafson, B. J. Bowman, and M. R. Boyd. Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases. J.Biol.Chem. 278 (45):44147-44152, 2003. PubMed link
  6. X. Chen, J. A. Beutler, A. Loehfelm, L. Yang, H-F. Dong, O. Chertov, J. J. Oppenheim, and O. M. Z. Howard. Tannic acid is a novel CXCL12 (SDF1)/CXCR4 inhibitor with potential anti-angiogenic activity. Clin.Cancer Res. 9:3115-3123, 2003. PubMed link
  7. K. L. Erickson, K. R. Gustafson, D. J. Milanowski, L. K. Pannell, J. R. Klose, and M. R. Boyd. Myriastramides A-C, new modified cyclic peptides from the Phillipines marine sponge Myriastra clavosa. Tetrahedron 59 (51):10231-10238, 2003. PubMed link
  8. B. R. O'Keefe, D. F. Smee, J. A. Turpin, C. J. Saucedo, K. R. Gustafson, T. Mori, D. Blakeslee, R. Buckheit, and M. R. Boyd. Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrob.Agents Chemother. 47 (8):2518-2525, 2003.PubMed link
  9. M. A. Parniak, K. L. Min, S. R. Budihas, S. F. J. Le Grice, and J. A. Beutler. A fluorescence-based high-throughput screening assay for inhibitors of HIV-1 reverse transcriptase associated ribonuclease H activity. Anal.Biochem. 322 (1):33-39, 2003. PubMed link
  10. C. C. Tsai, P. Emau, Y. Jiang, B. Tian, W. R. Morton, K. R. Gustafson, and M. R. Boyd. Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques. AIDS Res.Hum.Retroviruses 19 (7):535-541, 2003. PubMed link

2002

  1. L. G. Barrientos, J. M. Louis, I. Botos, T. Mori, Z. Z. Han, B. R. O'Keefe, M. R. Boyd, and A. M. Gronenborn. The domain-swapped dimer of cyanovirin-N is in a metastable folding intermediate. Reconciliation of X-ray and NMR structures. Structure 10:673-686, 2002. PubMed link
  2. L. G. Barrientos, J. M. Louis, J. Hung, T. H. Smith, B. R. O'Keefe, R. S. Gardella, T. Mori, M. R. Boyd, and A. M. Gronenborn. Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N. Proteins: Structure, Function and Genetics 46 (2):153-160, 2002. PubMed link
  3. J. A. Beutler, J. B. McMahon, T. R. Johnson, B. R. O'Keefe, R. A. Buzzell, D. Robbins, R. Gardella, J. Wilson, and M. R. Boyd. High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41. J.Biomolecular Screening 7 (2):105-110, 2002. PubMed link
  4. H. R. Bokesch, A. C. Stull, L. K. Pannell, T. C. McKee, and M. R. Boyd. A new pentacyclic sulfated hydroquinone from the marine sponge Haliclona sp. Tetrahedron Lett. 43:3079-3081, 2002.
  5. I. Botos, T. Mori, L. K. Cartner, M. R. Boyd, and A. Wlodawer. Domain-swapped structure of a mutant of cyanovirin-N. Biochem.Biophys.Res.Commun. 194:184-190, 2002. PubMed link
  6. I. Botos, B. R. O'Keefe, S. R. Shenoy, L. K. Cartner, D. M. Ratner, P. H. Seeberger, M. R. Boyd, and A. Wlodawer. Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high-mannose oligosaccharides.  J.Biol.Chem. 277 (37):34336-34342, 2002.PubMed link
  7. R. D. Charan, T. C. McKee, and M. R. Boyd. Thorectandrols C, D, and E, new sesterterpenes from the marine sponge Thorectandra sp. J.Nat.Prod. 65 (4):492-495, 2002. PubMed link
  8. R. D. Charan, T. C. McKee, K. R. Gustafson, L. K. Pannell, and M. R. Boyd. Thorectandramine, a novel ß-carboline alkaloid from the marine sponge Thorectandra sp. Tetrahedron Lett. 43 (29):5201-5204, 2002.
  9. K. L. Erickson, K. R. Gustafson, L. K. Pannell, J. A. Beutler, and M. R. Boyd. New dimeric macrolide glycosides from the marine sponge Myriastra clavosa. J.Nat.Prod. 65 (9):1303-1306, 2002. PubMed link
  10. B. Giomarelli, T. Mori, R. Provvedi, F. Meacci, T. Maggi, J. B. McMahon, R. Gardella, D. Medaglini, M. R. Boyd, and G. Pozzi. The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1. AIDS 16 (1351):1356, 2002. PubMed link
  11. Z. Z. Han, C. Y. Xiong, T. Mori, and M. R. Boyd. Discovery of a stable dimeric mutant of cyanovirin-N (CV-N) from a T7 phage-displayed CV-N mutant library. Biochem.Biophys.Res.Comm. 292 (4):1036-1043, 2002. PubMed link
  12. K. M. Meragelman, L. M. West, P. T. Northcote, L. K. Pannell, T. C. McKee, and M. R. Boyd. Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp. J.Org.Chem. 67 (19):6671-6677, 2002. PubMed link
  13. T. Mori, L. G. Barrientos, Z. Z. Han, A. M. Gronenborn, J. A. Turpin, and M. R. Boyd. Functional homologs of cyanovirin-N amenable to mass production in prokaryotic and eukaryotic hosts. Protein Expr.Purif. 26:42-49, 2002. PubMed link
  14. G. R. Pettit, S. Ducki, R. Tan, R. S. Gardella, J. B. McMahon, M. R. Boyd, G. R. III Pettit, P. M. Blumberg, N. E. Lewin, D. L. Doubek, L. P. Tackett, and M. D. Williams. Isolation and structure of pedilstatin from a Republic of Maldives Pedilanthus sp. J.Nat.Prod. 65 (9):1262-1265, 2002. PubMed link
  15. M. A. Rashid, K. R. Gustafson, R. C. Crouch, A. Groweiss, L. K. Pannell, Q. N. Van, and M. R. Boyd. Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin A, a new antitumor macrolide lactam from the sponge Poecillastra sp. Org.Lett. 4 (19):3293-3296, 2002. PubMed link
  16. S. R. Shenoy, L. G. Barrientos, D. M. Ratner, B. R. O'Keefe, P. H. Seeberger, A. M. Gronenborn, and M. R. Boyd. Multisite and multivalent binding between cyanovirin-N and branched oligomannosides: Calorimetric and NMR characterization. Chem.Biol. 9 (10):1109-1118, 2002. PubMed link

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Added by Beutler, John (NIH/NCI) [E] , last edited by Beutler, John (NIH/NCI) [E] on Jun 27, 2017 02:00 PM