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Center For Cancer Research National Cancer Institute
Lee Laboratory 

Publications

Recent selected publications from Dr. Lee's laboratory are listed below.
For a complete bibliography, see Dr. Lee's PubMed list of publications (with abstracts)

Lee, K H., Y. Johmura, L. -R. Yu, J. -E. Park, Y. Gao, J. K. Bang, M. Zhou, T. D. Veenstra, Bo Y. Kim, and K. S. Lee: Identification of a novel Wnt5a-CK1?-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J. 2012. (in press)

Qian, W. -J.,* J.-E. Park,* F. Liu, K. S. Lee,* and T. R. Burke, Jr*: Effects on Polo-like Kinase 1 Polo-box Domain Binding Affinities of Peptides Incurred by Structural Variation at the Phosphoamino Acid Position. Bioorg. & Med. Chem. 2012. (in press). Asterisks indicate co-first and co-senior authorships.

Liu, F.,* J.-E. Park,* W. -J. Qian, D. Lim, A. Scharow, T. Berg, M. B. Yaffe, K. S. Lee* and T. R. Burke, Jr.*: Peptoid-peptide hybrid ligands targeting the polo-box domain of polo-like kinase 1. Chembiochem. May 8. doi: 10.1002/cbic.201200206. Epub ahead of print. Asterisks indicate co-first and co-senior authorships.

Liu, F.,* J.-E. Park,* W. -J. Qian, D. Lim, A. Scharow, T. Berg, M. B. Yaffe, K. S. Lee* and T. R. Burke, Jr.* : Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using Oxime-based diversification. ACS Chem. Biol. 2012, 7:805-810. Asterisks indicate co-first and co-senior authorships.

Park, J.-E., R. L. Erikson, and K. S. Lee: A self-propelled biological process---Plk1-dependent, product-activated feed-forward mechanism. Cell Cycle. 2011, 10:1-2.

Johmura, Y., N.-K. Soung, J.-E. Park, L.-R. Yu, M. Zhou, J. K. Bang, B. Y. Kim, R. L. Erikson, T. D. Veenstra, and K. S. Lee: Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1. Proc. Natl. Acad. Sci. USA. 2011, 108:11446-11451

Liu, F.,* J.-E. Park,* W.-J. Qian, D. Lim, M. B. Yaffe, K. S. Lee*, and T. R. Burke*: Serendipitous alkylation of a Plk-1 ligand uncovers a new binding channel. Nat. Chem. Biol. 2011, 7:595-601. Asterisks indicate co-first and co-senior authorships.

Park, J.-E., R. L. Erikson, and K. S. Lee Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate. Proc. Natl. Acad. Sci. USA. 108:8200-8205, 2011.

Kang, Y. H., C. -H. Park, T. -S. Kim, N. -K. Soung, J. K. Bang, B. Y. Kim, J. -E. Park and K. S. Lee: Mammalian Polo-like Kinase 1-dependent Regulation of the PBIP1-CENP-Q Complex at Kinetochores J Biol Chem. 286:19744-19757, 2011.

Huong, P. T. T., D. O. Moon, S. O. Kim, K. E. Kim; S. J. Jeong, K. W. Lee, K. S. Lee, J. H. Jang, R. L. Erikson, J. S. Ahn, B. Y. Kim: Proteasome inhibitor-I Enhances Tunicamycin-induced Chemosensitization of Prostate Cancer Cells through regulation of NF-kB and CHOP expression. Cell. Signal. 23: 857-865, 2011.

Liao C*, Park JE*, Bang JK, Nicklaus MC, Lee KS: Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1. ACS Med. Chem. Lett. 1: 110-114, 2010. *These authors contributed equally to this work.

Park JE, Soung NK, Johmura Y, Kang YH, Liao C, Lee KH, Park CH, Nicklaus MC, Lee KS: Polo-box domain: a versatile mediator of polo-like kinase function. Cell. Mol. Life Sci. 67: 1957-70, 2010.

Soung NK, Park JE, Yu LR, Lee KH, Lee JM, Bang JK, Veenstra TD, Rhee K, Lee KS: Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells. Dev. Cell. 16: 539-50, 2009.

Liu F, Park JE, Lee KS, Burke Jr. TR: Preparation of orthogonally protected (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of polo-box domain-binding peptides. Tetrahedron. 65 (47): 9673-9679, 2009.

Yun SM*, Moulaei T*, Lim D*, Bang JK*, Park JE*, Shenoy SR*, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR, Yaffe MB, Wlodawer A, Lee KS: Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat. Struct. Mol. Biol. 16: 876-82, 2009. *These authors contributed equally to this work. (This work is highlighted on the cover of the issue.)

Park, JE, L. Li, J. Park, R Knecht, K Strebhadt, S. H. Yuspa, and K. S. Lee: Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay. Proc. Natl. Acad. Sci. USA. 106:1725-1730, 2009. (This work is highlighted in SciBX Vol. 2, p22, and Genetic Engineering News Vol. 29, Number 9.)

Lee, K. S., and J. R. Idle: Pinning down the polo-box domain. Chem. Biol. 15:415-416, 2008.

Soung, N.-K., JE. Park, L.-R. Yu, K. H. Lee, J.-M. Lee, J. K. Bang, T. D. Veenstra, K. Rhee, and K. S. Lee: Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells. Dev. Cell 16: 539-550, 2008.

Nakashima, A., Y. Maruki, Y. Miyoshi, C. Kondo, Y. Ohsumi, H. Takata, A. Matsuura, K. S. Lee, K. Yonezawa, and Y. Kamada: The Tor signaling pathway regulates mitotic entry via polo-kinase, PLoS ONE 3: e2223, 2008.

Park, CJ*, JE Park*, T. S. Karpova, N. K. Soung, L.-R. Yu, S. Song, K. H. Lee, X. Xia, E. Kang, I. Dabanoglu, D. Y. Oh, J. Y. Zhang, Y. H. Kang, S. Wincovitch, T. C. Huffaker, T. D. Veenstra, J. G. McNally, K. S. Lee: Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics. Eukaryot. Cell 7:444-453, 2008. *These authors contributed equally to this work.

Lee, K. S., D. Y. Oh, Y. H. Kang, J.-E. Park: Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction. Cell Div. 3:1-8, 2008.

Lee, K. S., J.-E. Park, Y. H. Kang, W. Zimmerman, N. K. Soung, Y. S. Seong, S. J. Kwak, and R. L. Erikson: Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: self- versus non-self-priming. Cell Cycle 7:141-145, 2008.

Kuriyama, R., Y. Terada, K. S. Lee, and C. L. C. Wang: Centrosome Replication in Hydroxyurea-arrested CHO Cells Expressing GFP-tagged Centrin2. J. Cell Sci. 120:2444-2453, 2007.

Kang, Y.-H., Y.-S. Seong, L.-R. Yu, N.-K. Soung, T. Veenstra, and K. S. Lee: Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Mol. Cell 24:409-422, 2006. (This work is previewed in Dai W. and Wang X. 2006 Mol. Cell 24:489-490.)

Park, J.-E. and K. S. Lee: Integration of cell cycle signals by Swe1/Wee1 in budding yeast. Invited commentary, Center for Cancer Research, Frontiers in Science 5: 2006.

Soung, N.-K., Y. H. Kang, K. Kim, K. Kamijo, H. Yoon, Y.-S. Seong, Y.-L. Kuo, T. Miki, S. R. Kim, R. Kuriyama, C.-Z. Giam, C. H. Ahn, and K. S. Lee: Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol. Cell. Biol. 26:8316-8335, 2006.

Asano, S*, JE Park*, L.-R. Yu, K. Sakchaisri, C. J. Park, Y. H. Kang, J. Thorner, T. D. Veenstra, K. S. Lee: Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast. J. Biol. Chem. 281:27090-27098, 2006. *These authors contributed equally to this work.

Niiya, F., T. Tatsumoto, K. S. Lee, and T. Miki: Phosphorylation of the cytokinesis regulator Ect2 by Cdk1 stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Oncogene 25:827-837, 2006.

Hara, T., M. Abe, H. Inoue, Y. H. Kang, K. S. Lee, and T. Miki: Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase. Oncogene 25:566-578. 2006.