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Center For Cancer Research National Cancer Institute
JB6 Mouse Model

JB6 References 2009
  1. Hwang MK, Song NR, Kang NJ, Lee KW, & Lee HJ. Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9. Its direct inhibition by quercetin. Int J Biochem Cell Biol 41(7): 1592-600, 2009.  Abstract
  2. Zhao J, Bowman L, Zhang X, Shi X, Jiang B, Castranova V, & Ding M. Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. J Nanobiotechnology 7: 2, 2009.  Abstract  Full Text 
  3. Kang MI, Henrich CJ, Bokesch HR, Gustafson KR, McMahon JB, Baker AR, Young MR, & Colburn NH. A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits". Mol Cancer Ther 8(3): 571-81, 2009.  Abstract  Full Text   
  4. Hwang MK, Kang NJ, Heo YS, Lee KW, & Lee HJ. Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. Biochem Pharmacol 77(7): 1213-22, 2009.  Abstract 
  5. Lee NY, Choi HK, Shim JH, Kang KW, Dong Z, & Choi HS. The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation. Carcinogenesis 30(4): 671-81, 2009.  Abstract 
  6. Murray AR, Kisin E, Leonard SS, Young SH, Kommineni C, Kagan VE, Castranova V, & Shvedova AA. Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes. Toxicology 257(3): 161-71, 2009.  Abstract 
  7. Kang NJ, Lee KW, Kwon JY, Hwang MK, Rogozin EA, Heo YS, Bode AM, Lee HJ, & Dong Z. Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling. Cancer Prev Res 1(7): 522-31, 2009.  Abstract  Full Text   
  8. Cho YY, Tang F, Yao K, Lu C, Zhu F, Zheng D, Pugliese A, Bode AM, & Dong Z. Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation. Cancer Res 69(1): 272-81, 2009.  Abstract  Full Text
  9. Kang NJ, Lee KW, Shin BJ, Jung SK, Hwang MK, Bode AM, Heo YS, Lee HJ, & Dong Z. Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis 30(2): 321-30, 2009.  Abstract  Full Text
  10. Zhang D, Li J, Gao J, & Huang C. C-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells. Toxicol Appl Pharmacol 235(1): 18-24, 2009.  Abstract 
  11. Wei Q, Jiang H, Matthews CP, & Colburn NH. Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies. Proc Natl Acad Sci USA 105(50): 19738-43, 2009.  Abstract  Full Text   
  12. Kim JE, Kwon JY, Lee DE, Kang NJ, Heo YS, Lee KW, & Lee HJ. MKK4 is a novel target for the inhibition of tumor necrosis factor-alpha-induced vascular endothelial growth factor expression by myricetin. Biochem Pharmacol 77(3): 412-21, 2009.  Abstract 
  13. Kumamoto T, Fujii M, & Hou DX. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett 275(1):17-26, 2009.  Abstract