The goals of the Cancer Redox Biology Faculty are to:
1) Investigate how the signal transduction and expression of genes are altered by redox stress using animal and cellular models of cancer.
2) Determine how carcinogenesis, tumor angiogenesis and proliferation is altered by redox stress using animal models of cancer.
3) Identify small molecules that alter the molecular targets of redox stress and to develop these as therapeutic agents in cancer prevention and treatment studies.
4) Develop and validate epidemiological markers of redox stress in cancer.
5) Investigate the reorganization of the extracellular matrix as a function of hypoxia.
6) Characterize how patient imaging profiles and response to therapy is altered by redox stress.
7) Educate NCI faculty and fellows about redox biology.