Randall Johnson, Ph.D.
National Cancer Institute at Frederick
Hours: Office Hours
Randall received two B.S. degrees from Utah State University in Statistics and Computational Mathematics in 2003, an MHS degree from the Johns Hopkins School of Public Health in 2005 and his PhD in Bioinformatics from the Conservatiore National des Arts et Metièr in 2013. His dissertation focused on the modeling of linkage disequilibrium in whole genome genetic association studies and was completed under Dr Cheryl Winkler, head of the Molecular Genetic Epidemiology Studies Section of the Basic Research Laboratory at the National Cancer institute. Starting in 2004, he has been working as a contractor for Leidos Biomedical Research at the Laboratory of Genomic Diversity (2004-2010) and the BSP CCR Genetics Core (2010-Present) at the National Cancer Institute in Frederick Maryland, providing statistical and technical support to researchers at the Center for Cancer Research.
I am interested in statistical problems encountered in the analysis of admixed populations and the effect of microbiome communities on health.
- Harris M, Burns CM, Becker EA, Braasch AT, Gostick E, Johnson RC, Broman KW, Price DA, Friedrich TC, O'Connor SL. Acute-phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus, Journal of Virology, 2013, 87 (16), 9353–9364
- Torres AR, Westover JB, Gibbons C, Johnson RC, Ward DC. Activating killer-cell immunoglobulin-like receptors (KIR) and their cognate HLA ligands are significantly increased in autism, Brain, Behavior and Immunity, 2012, 26 (7), 1122-7
- Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki M, Kimmel PL, Limou S, Ahuja TS, Berns JS, Simon E, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA. APOL1 trypanolytic sequence variants in focal segmental glomerulosclerosis and HIV-associated nephropathy: genetic risk and clinical phenotype, Journal of the American Society of Nephrology, 2011, 22 (11), 2129-37
- Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Kopp JB, Winkler CA, Nelson GW, Johnson RC, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW. Differential effects of MYH9 and APOL1 risk variants on FRMD3 association with diabetic ESRD in African Americans, PLoS Genetics, 2011, 7 (6), e1002150
- Johnson, R.C., Nelson, G.W., Troyer, J.L., Lautenberger, J.A., Kessing, B.D., Winkler, C.A., O'Brien, S.J. Accounting for multiple comparisons in a genome-wide association study (GWAS) BMC Genomics 11:724 (2010).
- Nelson GW, Freedman BI, Bowden DW, Langefeld CD, An P, Hicks PJ, Bostrom MA, Johnson RC, Kopp JB, Winkler CA. Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15, Human Molecular Genetics, 2010, 19 (9), 1805-15
- O'Connor SL, Lhost JJ, Becker EA, Detmer AM, Johnson RC, Macnair CE, Wiseman RW, Karl JA, Greene JM, Burwitz BJ, Bimber BN, Lank SM, Tuscher JJ, Mee ET, Rose NJ, Desrosiers RC, Hughes AL, Friedrich TC, Carrington M, O'Connor DH. MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques, Science Transitional Medicine, 2010, 2 (22), 22ra18
- An P, Johnson RC, Phair J, Kirk GD, Yu XF, Donfield S, Buchbinder S, Goedert JJ, Winkler CA. Loss of APOBEC3B Gene Increases Risk of HIV-1 Acquisition, Journal of Infectious Diseases, 2009, 200 (7), 1054-8
- Roelke ME, Brown MA, Troyer JL, Winterbach H, Winterbach C, Hemson G, Smith D, Johnson RC, Pecon-Slattery J, Roca AL, Alexander K, Klein L, Martinelli P, Krishnasamu K, O’Brien SJ. Pathological Manifestations of Feline Immunode?ciency Virus (FIV) Infection in Wild African Lions, Virology, 2009, 390 (1), 1-12
- Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, Jessen HK, Kelleher AD, Hecht FM, Sekaly RP, Rosenberg ES, Walker BD, Carrington M, Altfeld M. HIV-1-Speci?c CD8+ T Cell Responses During Primary Infection are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells, Journal of Virology, 2009, 83 (15), 7641-8
- Winkler CA An P, Johnson RC, Nelson GW, Kirk G. Expression of Duffy Antigen Receptor for Chemokines (DARC) has no Effect on HIV-1 Acquisition or Progression to AIDS in African Americans, Cell Host & Microbe, 2009, 5 (5), 411-13
- Guo X, Johnson RC, Deng H, Liao J, Guan L, Nelson GW, Tang M, Zheng Y, de The G, O’Brien SJ, Winkler CA, Zeng Y. Evaluation of Nonviral Risk Factors for Nasopharyngeal Carcinoma in a High-Risk Population of Southern China, International Journal of Cancer, 2009, 124 (12), 2942-7
- Kopp JB, Smith MW, Nelson G, Johnson RC, Freedman BI, Bowden DW, Oleksyk T, McKenzie LM, Kajiyama H, Ahuja TS, Berns JS, Briggs W, Cho ME, Dart RA, Kimmel PL, Korbet SM, Michel DM, Mokrzycki MH, Schelling JR, Simon E, Trachtman H, Vlahov D, Winkler CA. MYH9 is a Major-Effect Risk Gene for Focal Segmental Glomerulosclerosis, Nature Genetics, 2008, 40 (10), 1175-84
- Hendrickson SL, Jacobson LP, Nelson GW, Phair JP, Lautenberger J, Johnson RC, Kingsley L, Margolick JB, Detels R, Goedert JJ, O'Brien SJ. Host Genetic Influences on HAART Efficacy and AIDS-Free Survival, Journal of Acquired Immune Deficiency Syndromes, 2008, 48 (3), 263-71
- Hutcheson HB, Lautenberger JA, Nelson GW, Pontius JU, Kessing BD, Winkler CA, Smith MW, Johnson RC, Stephens R, Phair J, Goedert JJ, Donfield S, O'Brien SJ. Detecting AIDS restriction genes: From candidate genes to genome-wide association discovery, Vaccine, 2008, 26 (24), 2951-65
- Bashirova AA, Bleiber G, Qi Y, Hutcheson H, Yamashita T, Johnson RC, Cheng J, Alter G, Goedert J, Buchbinder S, Hoots K, Vlahov D, May M, Maldarelli F, Jacobson L, O'Brien SJ, Telenti A, Carrington M. Consistent Effects of TSG101 Genetic Variability on Multiple Outcomes of Exposure to Human Immunodeficiency Virus Type 1, Journal of Virology, 2006, 80 (14), 6757-63
- Guo XC, Scott K, Liu Y, Dean M, David V, Nelson GW, Johnson RC, Dilks HH, Lautenberger J, Kessing B, Martenson J, Guan L, Sun S, Deng H, Zheng Y, de The G, Liao J, Zeng Y, O'Brien SJ, Winkler CA. Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: Study design, methods and feasibility, Human Genomics, 2006, 2 (6), 365-75
- Yant LJ, Friedrich TC, Johnson RC, May G, Maness NJ, Enz AM, Lifson JD, O'Connor DH, Carrington M, Watkins DI. The High Frequency MHC Class I Allele Mamu-B*17 is Associated with Control of SIVmac239 Replication, Journal of Virology, 2006, 80 (10), 5074-7