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Scientific Section Leader 

Bailey Kessing
National Cancer Institute at Frederick
Building 560:21-78
Frederick, MD 21702-1201 U.S.A.
Ph: 301-846-5373

Bailey.Kessing@nih.gov

Biography

Bailey Kessing received his M.S. degree from the Department of Zoology of the University of Hawaii at Manoa working in the fields of molecular evolution and phylogeography in 1991. He then joined the Smithsonian Institute's Tropical Research Institute located in the Republic of Panama continuing to work on phylogeography with Dr. Harilaos Lessios ' research laboratory. While running the laboratory and research program, Bailey Kessing developed databases to support laboratory research and administration. Starting in 2001, Bailey Kessing has been working as a contractor for Leidos Biomedical Research at the CCR at the National Cancer Institute in Frederick Maryland supervising the BCGC core laboratories and building databases to support operations for the BCGC work.

Research:

LIMS Database System-The BCGC’s data storage and retrieval needs require flexible Laboratory Information Management System that is constantly modified for individual and changing needs. A great deal of my time is dedicated to address these ever changing needs for individuals and labs. I am most interested is streamlining workflow from sample collection to data collection. With this in mind I have been working integrating our laboratory protocols with the various instruments needed for our research.

Database Interfaces-Data access and integration is incredibly important to research advances in our group. I am currently experimenting with new interfaces for access and retrieving data from our LIMS. These will hopefully bare fruit in the near future with fuller data access and reports on data for researchers.

Publications

  1. Astermark J, Donfield SM, Gomperts ED, Schwarz J, Menius ED, Pavlova A, Oldenburg J, Kessing B, DiMichele DM, Shapiro AD, Winkler CA, Berntorp E; Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort. The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort. Blood. 2013 Feb 21;121(8):1446-54. doi: 10.1182/blood-2012-06-434803. Epub 2012 Dec 6.
  2. Deep sequencing and Circos analyses of antibody libraries reveal antigen-driven selection of Ig VH genes during HIV-1 infection. Xiao M, Prabakaran P, Chen W, Kessing B, Dimitrov DS. Exp Mol Pathol. 2013 Oct 21. pii: S0014-4800(13)00121-4. doi: 10.1016/j.yexmp.2013.10.004. [Epub ahead of print] PMID: 24158018 [PubMed - as supplied by publisher] Related citations
  3. Tang M, Lautenberger JA, Gao X, Sezgin E, Hendrickson SL, Troyer JL, David VA, Guan L, McIntosh CE, Guo X, Zheng Y, Liao J, Deng H, Malasky M, Kessing B, Winkler CA, Carrington M, Dé The G, Zeng Y, O'Brien SJ. The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove. PLoS Genet. 2012 Nov;8(11):e1003103. doi: 10.1371/journal.pgen.1003103. Epub 2012 Nov 29. PubMed PMID: 23209447.
  4. Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Smith MW, Strickland PT. DNA repair gene variants in relation to overall cancer risk: a population-based study. Carcinogenesis. 2012 Oct 26. Epub ahead of print PubMed PMID: 23027618. 
  5. Jorgensen TJ, Ruczinski I, Yao Shugart Y, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiol. 2012 Oct;36(5):e288-93. doi: 10.1016/j.canep.2012.05.001. Epub 2012 Jun 5. PubMed PMID: 22677152; PubMed Central PMCID: PMC3438291. 
  6. Ruczinski I, Jorgensen TJ, Shugart YY, Schaad YB, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis. 2012 Sep;33(9):1692-8. doi: 10.1093/carcin/bgs170. Epub 2012 May 11. PubMed PMID: 22581838. 
  7. Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Shugart YY, Strickland PT, Kao WH, Alani  RM, Smith MW, Alberg AJ. A community-based study of nucleotide excision repair polymorphisms in relation to the risk of non-melanoma skin cancer. J Invest Dermatol. 2012 May;132(5):1354-62. doi: 10.1038/jid.2012.4. Epub 2012 Feb 16. PubMed PMID: 22336945; PubMed Central PMCID: PMC3326207. 
  8. Lessios HA, Lockhart S, Collin R, Sotil G, Sanchez-Jerez P, Zigler KS, Perez AF, Garrido MJ, Geyer LB, Bernardi G, Vacquier VD, Haroun R, Kessing BD. Phylogeography and bindin evolution in Arbacia, a sea urchin genus with an unusual distribution. Mol Ecol. 2012 Jan;21(1):130-44. doi: 10.1111/j.1365-294X.2011.05303.x. Epub 2011 Oct 10. PubMed PMID: 21981354. 
  9. Chinn LW, Minzhong T, Kessing BD, Lautenberger JA, Troyer JL, Malasky MJ, McIntosh C, Kirk GD, Wolinsky SW, Buchbinder SP, Gomperts ED, Goedert JJ, and O’Brien SJ. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. J Infect Disease 202:1833-1845.
  10. Guo X, Zeng Y, Deng H, Liao J, Zheng Y, Li J, Kessing B, O'Brien SJ. 2010. Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China. BMC Research Notes 2010, 3:212
  11. Haussler D, O'Brien SJ, Ryder OA, Barker FK, Clamp M, Crawford AJ, Hanner R, Hanotte OH, Johnson W, McGuire J, Miller W, Murphy RW, Murphy WJ, Sheldon FH, Sinervo B, Venkatesh B, Wiley EI, Allendorf FW, Baker S, Bernardi G, Brenner S, et al. 2009. Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species. Website
  12. Herbeck JT, Gottlieb GS, Winkler CA, Nelson GW, An P, Maust BS, et al. Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. J Infect Dis. 2010;201(4):618-26.
  13. Johnson, R.C., Nelson, G.W., Troyer, J.L., Lautenberger, J.A., Kessing, B.D., Winkler, C.A.,  O'Brien, S.J. Accounting for multiple comparisons in a genome-wide association study (GWAS) BMC Genomics 11:724 (2010).
  14. Perelman P, Johnson W, Roos C, Seuanez HN, Horvath JE, Moreira MAM, Kessing B, Pontius J, Roelke M, Rumpler Y, Schneider PC, Silva A, O'Brien SJ, Pecon-Slattery J. 2010. A molecular phylogeny of living primates. PLoS Genetics 08/20/10.
  15. Sezgin E, Drosdak A, McIntosh C, Kessing B, Lautenberger JA, Goedert JJ, et al. Examination of disease-based selection, demographic history and population structure in european Y-chromosome haplogroup i. J Hum Genet. 2010;55(9):613-20.
  16. Troyer J, Chinn L, Lautenberger J, Nelson G, Johnson R, Tang M, Kessing B, McIntosh C, Sezgin E, O'Brien S. 2010 Genome-wide association study to discover AIDS restriction candidate genes and investigate the role of polymorphisms in HIV-Dependency Factors (HDFs). Conference on Retroviruses and Opportunistic Infection.
  17. Troyer JL, Nelson GW, Lautenberger JA, Chinn L, McIntosh C, Johnson RC, et al. Genome-wide association study implicates PARD3B-based AIDS restriction. J Infect Dis. 2011;203(10):1491-502.
  18. GENOME 10K COMMUNITY OF SCIENTISTS. 2009. Genome 10K: A Proposal to Obtain Whole-Genome Sequence for 10,000 Vertebrate Species. Journal of Heredity 10:1093
  19. Jorgensen TJ, Ruczinski I, Kessing B, Smith MW, Shugart YY, Alberg AJ. 2009. Hypothesis-Driven Candidate Gene Association Studies:  Practical Design and Analytical Considerations. Accepted Am J Epidemiol.
  20. Hutcheson HB, Lautenberger JA, Nelson GW, Pontius JU, Kessing BD, Winkler CA, Smith MW, Johnson R, Stephens R, Phair J, Goedert JJ, Donfield S, O'Brien SJ. 2008. Detecting AIDS restriction genes: From candidate genes to genome-wide association discovery. Vaccine 26(24):2951-65.
  21. Guo XC, O'Brien SJ, Winkler C., Scott K., Hutcheson H., David V., Kessing B., Zheng Y.M., Liao J., Lui Y., Guy de T. and Y. Zeng. 2006. Association study of chromosome 4 STRs polymorphisms with nasopharyngeal carcinoma. Yi Chuan. 28:783-90
  22. Guo, X.-C., Scott, K., Liu. Y., Dean, M., David, V., Nelson, G. W., Johnson, R. C., Dilks, H. H., Lautenburger, J., Kessing, B., Martenson, J., Guan L,  Sun, S., Deng, H., Zheng, Y., de The, G.,Liao, J.,   Zeng, Y., O'Brien, S. J.,  and C. A. Winkler. 2006. General Factors Leading to Chronic Epstein-Barr Virus Infection and Nasopharyngeal Carcinoma in South East China : Study Design, Methods and Feasibility. Human Genomics, 2:365-375
  23. Smith, MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Zeng Yi, de Thé G, Essex M, Sankalé JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien, SJ Reich D. 2004. A High-Density Admixture Map for Disease Gene Discovery in African Americans. Am. J. Hum. Genet. 74:1001--101
  24. Biermann C. Kessing BD, Palumbi SR. 2003. Phylogeny and development of marine model species: strongylocentrotid sea urchins. Evolution and Development 5:4, 360-371
  25. Lessios HA, Kessing BD, Pearse JS . 2001. Population structure and speciation in tropical seas: Global Phylogeography of the sea urchin Diadema . Evolution 55(5) 955-975.
  26. Lessios HA, Kessing BD, Robertson DR , Paulay G. 1999. Phylogeography of the pantropical sea urchin Eucidaris in relation to land barriers and ocean currents. Evolution 53:806-817.
  27. Lessios HA, Kessing BD, Robertson DR. 1998. Massive gene flow across the world's most potent marine biogeographic barrier. Proc. R. Soc. Lond. Ser. B. 265:583-588
  28. Lessios HA, Kessing BD, Wellington GM, Graybeal A. 1996. Indo-Pacific echinoids in the tropical eastern pacific. Coral Reefs 15:133-142
  29. Zanotto, PM, Kessing, BD, Maruniak, JE. 1993. Phylogenetic interrelationships among baculoviruses: Evolutionary rates and host associations. Journal of Invertebrate Pathology 62:147-164
  30. Palumbi SR, Kessing BD. 1991. Population biology of the trans-Arctic exchange: Mitochondrial DNA sequence similarity between Pacific an Atlantic sea urchins. Evolution 45:1790-1805
  31. Martin AP, Kessing BD, Palumbi SR. 1990. The accuracy of estimating genetic distance between species from short sequences of mitochondrial DNA. Molecular Biology and Evolution 7:485-488